Department of Medicine

Rheumatology Division

Research

 

Ellen Gravallese, MD Professor of Medicine 

Pathogenic mechanisms of inflammatory arthritis, with a special interest in rheumatoid arthritis. 

Identification of cell types producing matrix metalloproteinase enzymes that destroy the extracellular matrix of cartilage in disease such as rheumatoid arthritis and pigmented villonodular synovitis, and the identification of pathways leading to bone destruction in rheumatoid arthritis.  

Focal bone erosions in rheumatoid arthritis and the relationship of articular and systemic bone loss.  

Ann Marshak-Rothstein, PhD  Professor of Medicine
Factors regulating T and B lymphocyte activation, function, longevity, and apoptosis, especially in animal models of systemic autoimmune disease.

Regulatory functions of Fas-ligand. Fas-ligand was originally identified as a pro-apoptotic transmembrane protein critically involved in the regulation of T cells by activation induced cell death.

Animal models of pseudo-GVHD in which TCR transgenic T cells are specifically targeted to either MHC class II+ cells or to the vascular endothelium.

Judith A. Stebulis, MD Assistant Professor of Medicine 

Mechanisms whereby nonpsychoactive antiinflammatory cannabinoid acids exert their effects.