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Target- based drug design

Our Lab

Chemical Biology of Arginine Modifying Enzymes

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Welcome to the Thompson Lab! The focus of our group is the design of novel anti-cancer and anti-rheumatoid arthritis chemotherapeutics. Currently we are focusing our efforts on the development of potent and selective inhibitors of enzymes whose activities are involved in modulating chromatin structure.

Meet the Lab

  

Research Focus

Chemical Biology of Arginine Modifying Enzymes

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Our major focus is the target-based design of novel anti-cancer and anti-rheumatoid arthritis chemotherapeutics. Currently we are focusing our efforts on the development of potent and selective inhibitors of enzymes whose activities are involved in modulating chromatin structure. The modulation of chromatin structure can have drastic effects on the transcription of particular genes. Our lab uses kinetic and structural analyses to guide the design of small molecule inhibitors, which we then synthesize and evaluate as inhibitors of these enzymes. Protein Arginine Methyl-Transferases (PRMTs) catalyze the mono-, asymmetric di-, and symmetric di-methylation of Arginine residues in a number of proteins including the core histone proteins.

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Publications

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Total: 1 results
  • Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188

    Monday, January 25, 2021
    Author(s): Gordon J. Lockbaum, Archie C. Reyes, Jeong Min Lee, Ronak Tilvawala, Ellen A. Nalivaika, Akbar Ali, Nese Kurt Yilmaz, Paul R. Thompson, Celia A. Schiffer
    Source: Viruses; Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Contact

Office:

Lazare Research Building  LRB825
Campus Map (pdf)

Phone:
508.856.8333 (Admin. Assistant)
508.856.8874 (lab)

Email:
Paul.Thompson@umassmed.edu

Mailing Address:
UMASS Medical School
Paul Thompson, Ph.D.
Department of Biochemistry and Molecular Pharmacology
364 Plantation Street, LRB825
Worcester, MA 01605-4321

Join Us

We are always interested in applications from qualified candidates at graduate student, postdoctoral, and research associate levels.

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