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Recent Publications

Total: displaying 10 out of 57 results
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  • Structure and Dynamics of the CCCH-Type Tandem Zinc Finger Domain of POS-1 and Implications for RNA Binding Specificity

    Wednesday, September 25, 2024
    Author(s): Asli Ertekin,Brittany R Morgan,Sean P Ryder,Francesca Massi
    Source: Biochemistry
    CCCH-type tandem zinc finger (TZF) motifs are found in many RNA-binding proteins involved in regulating mRNA stability, translation, and splicing. In Caenorhabditis elegans, several RNA-binding protei...

  • The mex -3 3' untranslated region is essential for reproduction during temperature stress

    Monday, May 27, 2024
    Author(s): Hannah E Brown,Haik V Varderesian,Sara A Keane,Sean P Ryder
    Source: bioRxiv : the preprint server for biology
    Organisms must sense temperature and modify their physiology to survive environmental stress. Elevated temperature reduces fertility in most sexually reproducing organisms. Maternally supplied mRNAs a...

  • A nematode model to evaluate microdeletion phenotype expression

    Monday, November 13, 2023
    Author(s): Katianna R Antkowiak,Peren Coskun,Sharon T Noronha,Davide Tavella,Francesca Massi,Sean P Ryder
    Source: G3 (Bethesda, Md.)
    Microdeletion syndromes are genetic diseases caused by multilocus chromosomal deletions too small to be detected by karyotyping. They are typified by complex pleiotropic developmental phenotypes that ...

  • The role of RNA-binding proteins in orchestrating germline development in Caenorhabditis elegans

    Monday, January 23, 2023
    Author(s): Mennatallah M Y Albarqi,Sean P Ryder
    Source: Frontiers in cell and developmental biology
    RNA passed from parents to progeny controls several aspects of early development. The germline of the free-living nematode Caenorhabditis elegans contains many families of evolutionarily conserved RNA...

  • The endogenous mex-3 3´UTR is required for germline repression and contributes to optimal fecundity in C. elegans

    Monday, August 23, 2021
    Author(s): Mennatallah M Y Albarqi,Sean P Ryder
    Source: PLoS genetics
    RNA regulation is essential to successful reproduction. Messenger RNAs delivered from parent to progeny govern early embryonic development. RNA-binding proteins (RBPs) are the key effectors of this pr...

  • Analysis of Emerging Variants in Structured Regions of the SARS-CoV-2 Genome

    Friday, May 21, 2021
    Author(s): Sean P Ryder,Brittany R Morgan,Peren Coskun,Katianna Antkowiak,Francesca Massi
    Source: Evolutionary bioinformatics online
    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has motivated a widespread effort to understand its epidemiology and pathogenic mechanisms. Modern high-throughput sequencing ...

  • Analysis of Rapidly Emerging Variants in Structured Regions of the SARS-CoV-2 Genome

    Thursday, June 25, 2020
    Author(s): Sean P Ryder,Brittany R Morgan,Francesca Massi
    Source: bioRxiv : the preprint server for biology
    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has motivated a widespread effort to understand its epidemiology and pathogenic mechanisms. Modern high-throughput sequencing ...

  • A Disorder-to-Order Transition Mediates RNA Binding of the Caenorhabditis elegans Protein MEX-5

    Thursday, April 16, 2020
    Author(s): Davide Tavella,Asli Ertekin,Hila Schaal,Sean P Ryder,Francesca Massi
    Source: Biophysical journal
    CCCH-type tandem zinc finger (TZF) domains are found in many RNA-binding proteins (RBPs) that regulate the essential processes of post-transcriptional gene expression and splicing through direct prote...

  • #CRISPRbabies: Notes on a Scandal

    Tuesday, January 29, 2019
    Author(s): Sean P Ryder
    Source: The CRISPR journal
    No abstract

  • Multi-modal regulation of C. elegans hermaphrodite spermatogenesis by the GLD-1-FOG-2 complex

    Wednesday, January 02, 2019
    Author(s): Shuang Hu,Lauren E Skelly,Ebru Kaymak,Lindsay Freeberg,Te-Wen Lo,Scott Kuersten,Sean P Ryder,Eric S Haag
    Source: Developmental biology
    Proper germ cell sex determination in Caenorhabditis nematodes requires a network of RNA-binding proteins (RBPs) and their target mRNAs. In some species, changes in this network enabled limited XX spe...
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