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Research Highlights

NADH/NAD+ binding and linked tetrameric assembly of the oncogenic transcription factors CtBP1 and CtBP2.

Erlandsen H, Jecrois AM, Nichols JC, Cole JL, Royer WE Jr.

FEBS Lett. 2022 Feb;596(4):479-490. doi: 10.1002/1873-3468.14276. Epub 2022 Jan 17. PMID: 34997967.

NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP).

Nichols JC, Schiffer CA, Royer WE Jr.

J Biol Chem. 2021 Jan-Jun;296:100351. doi: 10.1016/j.jbc.2021.100351. Epub 2021 Jan 30. PMID: 33524397; PMCID: PMC7949142.

Cryo-EM structure of CtBP2 confirms tetrameric architecture.

Jecrois AM, Dcona MM, Deng X, Bandyopadhyay D, Grossman SR, Schiffer CA, Royer WE Jr.

Structure. 2021 Apr 1;29(4):310-319.e5. doi: 10.1016/j.str.2020.11.008. Epub 2020 Dec 1. PMID: 33264605; PMCID: PMC9159756.

Royer Lab Publications

Total: displaying 10 out of 26 results

NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP)

Monday, February 01, 2021

Author(s): Jeffry C Nichols,Celia A Schiffer,William E Royer

Source: The Journal of biological chemistry
Cryo-EM structure of CtBP2 confirms tetrameric architecture

Wednesday, December 02, 2020

Author(s): Anne M Jecrois,M Michael Dcona,Xiaoyan Deng,Dipankar Bandyopadhyay,Steven R Grossman,Celia A Schiffer,William E Royer

Source: Structure (London, England : 1993)
Optimizing the refinement of merohedrally twinned P61 HIV-1 protease-inhibitor cocrystal structures

Friday, March 06, 2020

Author(s): Gordon J Lockbaum,Florian Leidner,William E Royer,Nese Kurt Yilmaz,Celia A Schiffer

Source: Acta crystallographica. Section D, Structural biology
Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities

Wednesday, May 01, 2019

Author(s): M Michael Dcona,Priyadarshan K Damle,Francisco Zarate-Perez,Benjamin L Morris,Zaid Nawaz,Michael J Dennis,Xiaoyan Deng,Sudha Korwar,Sahib J Singh,Keith C Ellis,William E Royer,Dipankar Bandyopadhyay,Carlos Escalante,Steven R Grossman

Source: Molecular pharmacology
Assembly of human C-terminal binding protein (CtBP) into tetramers

Saturday, April 28, 2018

Author(s): Andrew G Bellesis,Anne M Jecrois,Janelle A Hayes,Celia A Schiffer,William E Royer

Source: The Journal of biological chemistry
Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

Saturday, April 29, 2017

Author(s): Takahide Kouno,Tania V Silvas,Brendan J Hilbert,Shivender M D Shandilya,Markus F Bohn,Brian A Kelch,William E Royer,Mohan Somasundaran,Nese Kurt Yilmaz,Hiroshi Matsuo,Celia A Schiffer

Source: Nature communications
Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP)

Monday, May 09, 2016

Author(s): Sudha Korwar,Benjamin L Morris,Hardik I Parikh,Robert A Coover,Tyler W Doughty,Ian M Love,Brendan J Hilbert,William E Royer,Glen E Kellogg,Steven R Grossman,Keith C Ellis

Source: Bioorganic & medicinal chemistry
Structure-guided design of a high affinity inhibitor to human CtBP

Saturday, January 31, 2015

Author(s): Brendan J Hilbert,Benjamin L Morris,Keith C Ellis,Janet L Paulsen,Celia A Schiffer,Steven R Grossman,William E Royer

Source: ACS chemical biology
Insight into the allosteric mechanism of Scapharca dimeric hemoglobin

Friday, October 31, 2014

Author(s): Jennifer M Laine,Miguel Amat,Brittany R Morgan,William E Royer,Francesca Massi

Source: Biochemistry
Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design

Tuesday, March 25, 2014

Author(s): Brendan J Hilbert,Steven R Grossman,Celia A Schiffer,William E Royer

Source: FEBS letters
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

Friday, November 19, 2010

Author(s): Keith P Romano,Akbar Ali,William E Royer,Celia A Schiffer

Source: Proceedings of the National Academy of Sciences of the United States of America
Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces

Tuesday, February 16, 2010

Author(s): Shivender M D Shandilya,Madhavi N L Nalam,Ellen A Nalivaika,Phillip J Gross,Johnathan C Valesano,Keisuke Shindo,Ming Li,Mary Munson,William E Royer,Elena Harjes,Takahide Kono,Hiroshi Matsuo,Reuben S Harris,Mohan Somasundaran,Celia A Schiffer

Source: Structure (London, England : 1993)
Structural insights into interferon regulatory factor activation

Saturday, January 02, 2010

Author(s): Weijun Chen,William E Royer

Source: Cellular signalling
Ligand migration and cavities within Scapharca Dimeric HbI: studies by time-resolved crystallo-graphy, Xe binding, and computational analysis

Tuesday, November 17, 2009

Author(s): James E Knapp,Reinhard Pahl,Jordi Cohen,Jeffry C Nichols,Klaus Schulten,Quentin H Gibson,Vukica Srajer,William E Royer

Source: Structure (London, England : 1993)
Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5

Tuesday, October 07, 2008

Author(s): Weijun Chen,Suvana S Lam,Hema Srinath,Zhaozhao Jiang,John J Correia,Celia A Schiffer,Katherine A Fitzgerald,Kai Lin,William E Royer

Source: Nature structural & molecular biology
Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3

Tuesday, April 29, 2008

Author(s): Weijun Chen,Hema Srinath,Suvana S Lam,Celia A Schiffer,William E Royer,Kai Lin

Source: Journal of molecular biology
Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling

Wednesday, February 07, 2007

Author(s): Weijun Chen,Suvana S Lam,Hema Srinath,Celia A Schiffer,William E Royer,Kai Lin

Source: The Journal of biological chemistry
An optical signal correlated with the allosteric transition in Scapharca inaequivalvis HbI

Thursday, December 21, 2006

Author(s): Jeffry C Nichols,William E Royer,Quentin H Gibson

Source: Biochemistry
Low resolution crystal structure of Arenicola erythrocruorin: influence of coiled coils on the architecture of a megadalton respiratory protein

Tuesday, November 07, 2006

Author(s): William E Royer,Michael N Omartian,James E Knapp

Source: Journal of molecular biology
Lumbricus erythrocruorin at 3.5 A resolution: architecture of a megadalton respiratory complex

Tuesday, July 18, 2006

Author(s): William E Royer,Hitesh Sharma,Kristen Strand,James E Knapp,Balaji Bhyravbhatla

Source: Structure (London, England : 1993)
Allosteric action in real time: time-resolved crystallographic studies of a cooperative dimeric hemoglobin

Thursday, May 11, 2006

Author(s): James E Knapp,Reinhard Pahl,Vukica Srajer,William E Royer

Source: Proceedings of the National Academy of Sciences of the United States of America
Residue F4 plays a key role in modulating oxygen affinity and cooperativity in Scapharca dimeric hemoglobin

Thursday, November 03, 2005

Author(s): James E Knapp,Michele A Bonham,Quentin H Gibson,Jeffry C Nichols,William E Royer

Source: Biochemistry
Allosteric hemoglobin assembly: diversity and similarity

Saturday, June 04, 2005

Author(s): William E Royer,Hao Zhu,Thomas A Gorr,Jason F Flores,James E Knapp

Source: The Journal of biological chemistry
Crystal structure of the hemoglobin dodecamer from Lumbricus erythrocruorin: allosteric core of giant annelid respiratory complexes

Wednesday, October 27, 2004

Author(s): Kristen Strand,James E Knapp,Balaji Bhyravbhatla,William E Royer

Source: Journal of molecular biology
Immobilization of Scapharca HbI crystals improves data quality in time-resolved crystallographic experiments

Wednesday, March 24, 2004

Author(s): James E Knapp,Vukica Srajer,Reinhard Pahl,William E Royer

Source: Micron (Oxford, England : 1993)
Ligand-linked structural transitions in crystals of a cooperative dimeric hemoglobin

Wednesday, April 23, 2003

Author(s): James E Knapp,William E Royer

Source: Biochemistry

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UMass Memorial Health gift, with matching funds from UMass Foundation, to fund five new endowed chairs at UMass Chan

Royer Lab Publications

NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP)

Cryo-EM structure of CtBP2 confirms tetrameric architecture

Optimizing the refinement of merohedrally twinned P61 HIV-1 protease-inhibitor cocrystal structures

Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities

Assembly of human C-terminal binding protein (CtBP) into tetramers

Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP)

Structure-guided design of a high affinity inhibitor to human CtBP

Insight into the allosteric mechanism of Scapharca dimeric hemoglobin

Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design

Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces

Structural insights into interferon regulatory factor activation

Ligand migration and cavities within Scapharca Dimeric HbI: studies by time-resolved crystallo-graphy, Xe binding, and computational analysis

Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5

Contribution of Ser386 and Ser396 to activation of interferon regulatory factor 3

Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling

An optical signal correlated with the allosteric transition in Scapharca inaequivalvis HbI

Low resolution crystal structure of Arenicola erythrocruorin: influence of coiled coils on the architecture of a megadalton respiratory protein

Lumbricus erythrocruorin at 3.5 A resolution: architecture of a megadalton respiratory complex

Allosteric action in real time: time-resolved crystallographic studies of a cooperative dimeric hemoglobin

Residue F4 plays a key role in modulating oxygen affinity and cooperativity in Scapharca dimeric hemoglobin

Allosteric hemoglobin assembly: diversity and similarity

Crystal structure of the hemoglobin dodecamer from Lumbricus erythrocruorin: allosteric core of giant annelid respiratory complexes

Immobilization of Scapharca HbI crystals improves data quality in time-resolved crystallographic experiments

Ligand-linked structural transitions in crystals of a cooperative dimeric hemoglobin