We study the transfer of epigenetic information via sperm as well as how genomic structure is regulated in yeast.
Epigenetic factors act as a filter influencing the genomic information available to a cell. Dissecting how this filter is regulated can lead to better understandings of cell fate determination and stability, which are altered in disease states.
Our lab brings together expertise in genomics, reproductive biology, microscopy, genetics, and biochemistry
We are a focused and dedicated group of researchers.
Revisiting chromatin packaging in mouse sperm.
Yin Q, Yang CH, Strelkova OS, Wu J, Sun Y, Gopalan S, Yang L, Dekker J, Fazzio TG, Li XZ, Gibcus J, Rando OJ.
Genome Res. 2023 Dec 27;33(12):2079-2093. doi: 10.1101/gr.277845.123. PMID: 38129076; PMCID: PMC10760523.
Evidence for RNA or protein transport from somatic tissues to the male reproductive tract in mouse.
Rinaldi V, Messemer K, Desevin K, Sun F, Berry BC, Kukreja S, Tapper AR, Wagers AJ, Rando OJ.
Elife. 2023 Mar 27;12:e77733. doi: 10.7554/eLife.77733. PMID: 36971355; PMCID: PMC10079288.
Stability of the cytosine methylome during post-testicular sperm maturation in mouse.
Galan C, Serra RW, Sun F, Rinaldi VD, Conine CC, Rando OJ.
PLoS Genet. 2021 Mar 4;17(3):e1009416. doi: 10.1371/journal.pgen.1009416. PMID: 33661909; PMCID: PMC7963034.
