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Selected Publications (out of 28 total)

  1. KJ Foster, HK Cheesman, P Liu, ND Peterson, R Pukkila-Worley. Innate immunity in the C. elegans intestine is programmed by a neuronal regulator of AWC olfactory neuron development. Cell Reports. 2020;31:1007478 (link)

  2. J Nhan, CD Turner, SM Anderson, CA Yen, HM Dalton, HK Cheesman, DL Reuter, N Uma Naresh, CM Haynes, AA Soukas, R Pukkila-Worley,* SP Curran.* Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection. PNAS USA. 2019;116:22322-22330. *co-corresponding authors (link)

  3. SM Anderson, ND Peterson, HK Cheesman, JE Salisbury, AA Soukas, R Pukkila-Worley.The monounsaturated fatty acid oleate is required for innate immune activation in C. elegans. PLOS Pathogens. 2019;15:e1007893 (link).

  4. ND Peterson,HK Cheesman, P Liu, SM Anderson, KJ Foster,R Chhaya, P Perrat, J Thekkiniath, Q Yang, CM Haynes, R Pukkila-Worley. The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegansPLOS Genetics. 2019;15:e1007935 (link).

  5. P Deng, N Uma Naresh, Y Du, R Pukkila-Worley and CM Haynes. Pseudomonas aeruginosa virulence impairs the UPRmt by engaging a host negative feedback loop. Proceedings of the National Academy of Sciences U.S.A. 2019 (in press).

  6. ND Peterson and R Pukkila-Worley. Caenorhabditis elegans in high-throughput screens for anti-infective compounds. Current Opinion in Immunology. 2018;54:59-65. (link)

  7. HK Cheesman, RL Feinbaum, J Thekkiniath, RH Dowen, AL Conery, R Pukkila-Worley. Aberrant activation of p38 MAP kinase-dependent innate immune responses is toxic to C. elegans. G3: Genes, Genomes, Genetics. 2016;6:541-549. (link)

  8. R Pukkila-Worley. Surveillance immunity: An emerging paradigm of Innate Defense Activation in Caenorhabditis elegansPLOS Pathogens. 2016;12:e1005795. (pdf)

  9. R Pukkila-Worley,* RL Feinbaum, DL McEwan, AL Conery, FM Ausubel. The evolutionarily conserved mediator subunit MDT-15/MED15 links protective innate immune responses and xenobiotic detoxification. PLOS Pathogens. 2014; 10:e1004143.*corresponding author (pdf)

  10. R Pukkila-Worley, N Valentina and JA Branda. Case records of the Massachusetts General Hospital. Case-28-2014: A 39-year-old man with a rash, headache, fever, nausea and photophobia. New England Journal of Medicine. 2014;371:1051-1060. (link)

  11. B Chan, E Hohmann, MB Barshak, Read Pukkila-Worley. Treatment of listeriosis in the first trimester of pregnancy. Emerging Infectious Diseases. 2013;19:839-41.  (link)

  12. R Pukkila-Worley, R Feinbaum, NV Kirienko, J Larkins-Ford, AL Conery, FM Ausubel. Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection. PLOS Genetics. 2012;8:e1002733. (Featured Research Article) (pdf)

  13. R Pukkila-Worley and FM Ausubel. Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium. Current Opinion in Immunology. 2012;1:3-9. (link)

  14. R Pukkila-Worley, FM Ausubel and E Mylonakis. Candida albicans infection of Caenorhabditis elegans induces antifungal immune defenses. PLOS Pathogens. 2011;7:e1002074. (Featured Research Article) (pdf)

  15. R Pukkila-Worley, AY Peleg, E Tampakakis and E Mylonakis. Candida albicans hyphal formation and virulence assessed using a Caenorhabditis elegans infection model. Eukaryotic Cell. 2009;8:1750. (Cover) (link)

  16. R Pukkila-Worley and E Mylonakis. Epidemiology and management of cryptococcal meningitis: developments and challenges. Expert Opinion in Pharmacotherapy. 2008;9:551-60. PMID: 18312157 (link)

  17. R Pukkila-Worley, QD Gerrald, PR Kraus, MJ Boily, MJ Davis, SS Giles, GM Cox, J Heitman and JA Alspaugh. Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cAMP cascade. Eukaryotic Cell.2005;1:190-201. (link)

  18. JA Alspaugh, R Pukkila-Worley, T Harashima, LM Cavallo, D Funnell, GM Cox, JR Perfect, JW Kronstad and J Heitman. Adenylyl cyclase functions downstream of the G-alpha protein Gpa1 and controls mating and pathogenicity in Cryptococcus neoformans. Eukaryotic Cell. 2001;1:75-84. (link)