Harrold Leslie

Leslie Harrold,

Associate Professor

Faculty Appointment in:
  • Orthopedics and Physical Rehabilitation (Medicine)

Phone: 508 856 6139

Leslie Harrold research Page

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Research Interests


Research Focus

    Leslie Harrold is an Associate Professor of Orthopedics and Physical Rehabilitation at the University of Massachusetts Medical School, and a Senior Research Associate at the Meyers Primary Care Institute (a joint endeavor of the University of Massachusetts Medical School, the Fallon Foundation and Fallon Community Health Plan).  She is a board-certified rheumatologist, an epidemiologist and a health services researcher.  Dr. Harrold has extensive experience using administrative claims data as well as registry data to identify patients with rheumatic conditions, assess their medication usage, health care utilization and outcomes.  She is interested in improving quality of care and patient’s ability to manage his or her own condition.  She has received a mentored career development award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS AR053856); this research focus on medication adherence in gout based on pharmacy dispensings at two health plans and on identifying the patient and provider barriers to optimal care though use of in-depth interviews and questionnaires.  She is also a co-investigator on FORCE-TJR, a nationwide registry examining the outcomes of total joint replacement surgery (PI Patricia Franklin) including pain, function and adverse events; she leads the collection of the clinical data to both identify and confirm adverse events.


Mount Holyoke College, BA Biology, 1998
University of Massachusetts Medical School, MD, 1992
University of Massachusetts, MPH, 1999
Residency, UMass Medical Center
Fellowship, Rheumatology

Recent Publications
























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Chen Y, Harrold LR, Yood RA, Field TS, Briesacher BA. Identifying Patients With Osteoporosis or at Risk for Osteoporotic Fractures. American Journal of Managed Care 2012; 18 (2):e61-e67. PMID:22435886

Saczynski JS, Andrade SE, Harrold LR, Tjia J, Cutrona SL, Dodd KS, Goldberg RJ, Gurwitz JH. A systematic review of validated methods for identifying heart failure using administrative data. Pharmacoepidemiology and Drug Safety 2012; 21 (S1):129-140. PMID:22262599

Andrade SE, Harrold LR, Tjia J, Cutrona SL, Saczynski JS, Dodd KS, Goldberg R, Gurwitz J. A systematic review of validated methods for identifying cerebrovascular accident or transient ischemic attack using administrative data. Pharmacoepidemiology and Drug Safety 2012; 21 (S1):100-128. PMID:22262598

Harrold LR, Harrington JT, Curtis JR, Furst DE, Bentley MJ, Shan Y, Reed G, Kremer J, Greenberg JD. Prescribing practices in a US cohort of rheumatoid arthritis patients before and after publication of the ACR treatment recommendations. Arthritis & Rheumatism 2012; 64 (3): 630–638. PMID: 21953645

Greenberg JD, Reed G, Decktor D, Harrold LR, Furst DE, Gibofsky A, DeHoratius R, Kishimoto M, Kremer, JM. A comparative effectiveness study of adalimumab, etanercept and infliximab in biological naive and switched rheumatoid arthritis patients: results from the United States CORRONA registry. Annals of the Rheumatic Diseases 2012; 71(7):1134-42. PMID: 22294625

Toh S, Li L, Harrold LR, Bayliss EA, Curtis JR, Liu L, Chen L, Grijalva CG, Platt R, Herrinton LJ. Comparative safety of infliximab and etanercept on the risk of serious infections—Does the association vary by patient characteristics? Pharmacoepidemiology and Drug Safety 2012; 21(5):524-534. PMID:22411435

Harrold LR, Peterson D, Beard AJ, Gurwitz JH, Briesacher BA. Time trends in the use of disease modifying anti-rheumatic drugs (DMARDs) and expenditures in older patients with rheumatoid arthritis. American Journal of Medicine. 2012 Sep;125(9):937.e9-15. PMID:22682794

Fisher MC, Furer V, Hochberg MC, Greenberg JD, Kremer JM, Curtis JR, Reed G, Harrold LR and Daniel H Solomon Malignancy Validation in a United States Registry of Rheumatoid Arthritis Patients. BMC Musculoskeletal Disorders 2012 May 31;13:85. doi: 10.1186/1471-2474-13-85. PMID:22651246

Tjia J, Field TS, Mazor KM, Donovan JL, Kanaan AO, Reed G, Doherty P, Harrold LR, Gurwitz JH. Dementia and Risk of Adverse Warfarin-related Events in the Nursing Home Setting. Am J Geriatr Pharmacother. 2012 Oct;10(5):323-30. PMID: 23063288

Herrinton LJ, Liu L, Chen L, Harrold LR, Raebel MA, Curtis JR, Griffin MR, Solomon DH, Saag KG, Lewis JD. Association Between Anti-TNF-α Therapy and All-Cause Mortality. Pharmacoepidemiol Drug Saf. 2012 Oct 15. doi: 10.1002/pds.3354. PMID:23065964

Harrold LR, Mazor KM, Peterson D, Naz N, Firneno C, Yood RA. Patients’ knowledge and beliefs concerning gout and its treatment: a population based study. BMC Musculoskelet Disord. 2012 Sep 21;13(1):180. PMID: 22995041

Prowse RL, Dalbeth N, Kavanaugh A, Adebajo A, Gaffo AL, Terkeltaub R, Mandel B, Suryana BP, Goldenstein-Schainberg C, Diaz-Torne C, Khanna D, Liote F, Perez-Ruiz F, Sivera F, McCarthy G, Kerr GS, Yamanaka H, Janssens H, Baraf H, Chen JH, Vazquez-Mellado J, Harrold LR, Stamp L, Edwards L, van de Laar MA, Jannssen M, Becker M, Doherty M, Boers M, Schlesinger N, Chapman P, Simkin P, Gow P, Khanna P, Helliwell PS, Grainger R, Burgos-Vargas R, Schumacher HR, Day R, Alten R, Neogi T, Jansen TL, Mikuls T, Louthrenoo W, Taylor WJ. A Delphi exercise to identify specific features of gout—a study of opinions from patient and physicians. (in press)

Rathbun AM, Reed GW, Harrold LR. The Temporal Relationship between Depression and Rheumatoid Arthritis Disease Activity, Treatment Persistence and Response: A Systematic Review. (in press)

Harrold LR, Briesacher BA, Peterson D, Beard A, Madden J, Zhang F, Gurwitz JH, Soumerai SB. Cost Related Medication Nonadherence in Older Rheumatoid Arthritis Patients. (in press)





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"Improving Orthopedic Outcomes Through a National TJR Registry"
Sponsor: NIH-Agency for Healthcare Research and Quality
Patricia Franklin, Principal Investigator; David Ayers, CO-Investigator; Paul Fanning, CO-Investigator; Leslie Harrold, CO-Investigator; Wenjun Li, CO-Investigator.
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