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PBCE Resources

Resources such as tutorials and tips for working with PacBio data will be posted here.

Introduction/Basics
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Grant Support and Funding
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  • The UMass PacBio Core Enterprise (PBCE) will provide a formal letter of support to include in grant applications.
  • Pacific Biosciences offers several SMRT Grant Programs to support research that can be applied at the UMMS PBCE facility.

Protocols
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Tools
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Data and Bioinformatics
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Working with BAM Files

PacBio Data Analyses

PacBio Data Information

  • Coming soon: explanations of the data files you will receive, where to find specific information, what we need from you to carry out analyses (such as genome files for mapping).

Publications
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The PacBio Core Enterprise would be pleased to have you mention us in the acknowledgements section of any publications or presentations of data generated with our support.
If you would like to have your publication listed on the Core's website to help highlight the work UMass researchers are doing, email us the reference at PacBio@umassmed.edu.

A collection of papers highlighting applications possible with PacBio technology
https://www.mdpi.com/journal/genes/special_issues/SMRT_sequencing#info

Improved assembly and variant detection of a haploid human genome using single-molecule, high-fidelity long reads
https://www.ncbi.nlm.nih.gov/pubmed/31711268/

RADAR-seq: A RAre DAmage and Repair sequencing method for detecting DNA damage on a genome-wide scale
https://www.ncbi.nlm.nih.gov/pubmed/31247470/

The Origin of the Haitian Cholera Outbreak Strain
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030187/

Direct Detection and Sequencing of Damaged DNA Bases
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264494/

Direct Detection of DNA Methylation During Single-Molecule, Real-Time Sequencing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879396/

Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287169/

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia
http://www.ncbi.nlm.nih.gov/pubmed/22504184/

Going beyond five bases in DNA Sequencing
http://www.ncbi.nlm.nih.gov/pubmed/22575758

Massively multiplex single-molecule oligonucleosome footprinting
https://pubmed.ncbi.nlm.nih.gov/33263279/

UMMS Deep Sequencing Core logo linking to website

UMMS Molecular Biology Core Labs logo linking to website