How can we use bioluminescence to probe biological processes?

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  Work in our lab ranges from curiosity-driven basic science questions to the directed development and optimization of luciferases and luciferins for bioluminescence imaging in mice using adeno-associated virus (AAV) to deliver designer luciferase-based reporters to specific tissues.  

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Need sentence decribing why you do it

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  Our multi-disciplinary approach brings together the areas of synthetic organic chemistry, molecular biology, biochemistry, and cell biology, with translation into mouse models of disease.

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We are a small and dedicated group of researchers who enjoy pursuing curiosity-based and application-driven projects.

 


Research Highlights

Silicon functionalization expands the repertoire of Si-rhodamine fluorescent probes. 
Rao DN, Ji X, Miller SC. 

Chem Sci. 2022 May 2;13(20):6081-6088. doi: 10.1039/d2sc01821g. PMID: 35685786; PMCID: PMC9132037.


Bioluminescence imaging in mice with synthetic luciferin analogues.
Ji X, Adams ST Jr, Miller SC. 

Methods Enzymol. 2020;640:165-183. doi: 10.1016/bs.mie.2020.04.033. Epub 2020 May 31. PMID: 32560797; PMCID: PMC8345814.


Adams ST Jr, Miller SC.
 
FEBS J. 2020 Apr;287(7):1369-1380. doi: 10.1111/febs.15176. Epub 2019 Dec 27. PMID: 31828943; PMCID: PMC7217382.

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