Jul 31, 2024
Celebrating RNA Day with Dr. Thoru Pederson
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The focus of my research is to investigate how the function of a protein is determined by the relationship between its structure, stability and dynamics.
We combine a variety of experimental and computational techniques to characterize the structure, dynamics, stability and activity of proteins.
Proteins are flexible molecules that often undergo conformational changes to perform biological functions. For this reason, knowledge of the structure and internal dynamics of proteins is crucial to an understanding of the details of their functions and mechanisms of action.
We are a team of passionate scientists committed to unraveling the molecular mechanisms that drive protein function.
A hydrophobic core stabilizies the residual structure in the RRM2 intermediate state of the ALS-linked protein TDP-43
Mackness BC, Morgan BR, Deveau LM, Kathuria SV, Zitzewitz JA, Massi F.
J Mol Biol. 2024 Nov 15;436(22):168823. doi: 10.1016/j.jmb.2024.168823. Epub 2024 Oct 18. PMID: 39426615.
Structure and dynamics of the CCCH-type tandem zinc finger domain of POS-1 and implications for RNA binding specificity
Ertekin A, Morgan BR, Ryder SP, Massi F.
Biochemistry. 2024 Oct 15;63(20):2632-2647. doi: 10.1021/acs.biochem.4c00259. Epub 2024 Sep 25. PMID: 39321355.
Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia
Funes S, Jung J, Gadd DH, Mosqueda M, Zhong J, Shankaracharya, Unger M, Stallworth K, Cameron D, Rotunno MS, Dawes P, Fowler-Magaw M, Keagle PJ, McDonough JA, Boopathy S, Sena-Esteves M, Nickerson JA, Lutz C, Skarnes WC, Lim ET, Schafer DP, Massi F, Landers JE, Bosco DA.
Nat Commun. 2024 Mar 20;15(1):2497. doi: 10.1038/s41467-024-46695-w. PMID: 38509062; PMCID: PMC10954694.
