Jul 31, 2024
Celebrating RNA Day with Dr. Thoru Pederson
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We characterize the structure and dynamics of protein-RNA complexes to understand how they function at the molecular level.
We utilize biophysical, biochemical, and in vivo techniques with a particular emphasis on NMR spectroscopy and computational methods.
Understanding protein-RNA complex dynamics is crucial to a variety of cellular processes affecting human health and disease.
We are a tight-knit team dedicated to excellence in our own research and in that of our collaborators through the Massachusetts NMR Consortium.
A hydrophobic core stabilizies the residual structure in the RRM2 intermediate state of the ALS-linked protein TDP-43
Mackness BC, Morgan BR, Deveau LM, Kathuria SV, Zitzewitz JA, Massi F.
J Mol Biol. 2024 Nov 15;436(22):168823. doi: 10.1016/j.jmb.2024.168823. Epub 2024 Oct 18. PMID: 39426615.
Structure and dynamics of the CCCH-type tandem zinc finger domain of POS-1 and implications for RNA binding specificity
Ertekin A, Morgan BR, Ryder SP, Massi F.
Biochemistry. 2024 Oct 15;63(20):2632-2647. doi: 10.1021/acs.biochem.4c00259. Epub 2024 Sep 25. PMID: 39321355.
Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia
Funes S, Jung J, Gadd DH, Mosqueda M, Zhong J, Shankaracharya, Unger M, Stallworth K, Cameron D, Rotunno MS, Dawes P, Fowler-Magaw M, Keagle PJ, McDonough JA, Boopathy S, Sena-Esteves M, Nickerson JA, Lutz C, Skarnes WC, Lim ET, Schafer DP, Massi F, Landers JE, Bosco DA.
Nat Commun. 2024 Mar 20;15(1):2497. doi: 10.1038/s41467-024-46695-w. PMID: 38509062; PMCID: PMC10954694.
