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Protein-RNA Interactions

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Understanding protein-RNA interactions with biophysical and computational approaches

RNA binding proteins can control protein expression by regulating transport, localization, splicing, polyadenylation and turnover of mRNA transcripts. Characterization of the structure and dynamics of protein-RNA complexes is essential for understanding how they function at the molecular level: how these proteins specifically recognize their target RNAs, what are the structure-function relationships, and assess their biological role in regulating gene expression. To achieve these goals, our laboratory uses biophysical, biochemical and in vivo techniques with a particular emphasis on NMR spectroscopy and computational methods.

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Understanding protein-RNA interactions using biophysical and computational techniques

RNA binding proteins can control protein expression by regulating transport, localization, splicing, polyadenylation and turnover of mRNA transcripts. Characterization of the structure and dynamics of protein-RNA complexes is essential for understanding how they function at the molecular level: how these proteins specifically recognize their target RNAs, what are the structure-function relationships, and to assess their biological role in regulating gene expression. To achieve these goals, our laboratory uses biophysical, biochemical and in vivo techniques with a particular emphasis on NMR spectroscopy and computational methods.

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Office:
Lazare Research Building 925
Campus Map (pdf)

Phone:
508-856-4501 (office)

Email:
Francesca.Massi@umassmed.edu

Mailing Address:
University of Massachusetts Medical School
Attn: Dr. Francesca Massi/BMP department
364 Plantation St LRB925
Worcester, MA 01605

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We are always interested in applications from qualified candidates at postdoctoral and research associate levels.

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Undergraduates interested in pursuing a PhD at UMass Medical School should apply directly to the Graduate School of Biomedical Sciences Program.

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