Cell line & Culture Development
MassBiologics welcomes projects from vector construction to harvest. MassBiologics can develop an optimized batch-fed process for the production of therapeutic candidates, further; MassBiologics can help optimize an existing process. Our team has experience working with most commonly used mammalian cell lines including CHO, NS0 & HEK.
MassBiologics may be able to accelerate upstream process development timelines by providing access to its proprietary serum-free, chemically defined media. This expression platform technology is well suited for monoclonal antibody production and routinely delivers titers in the range of 3-5 g/L.
High throughput screening / optimization can be performed in up to 500 simultaneous shaker flask experiments. Resources available include:
- 10 Benchtop bioreactors are available (DasGip™ & Applikon™)
- Scale up bioreactors (10L DasGip, 60L Applikon™)
- WAVE disposable bioreactors (2-20L)
- Millpore™ Pod Filtration System
- Nova Analyzers
- ForteBio™ Octet® Analyzers
- Cedex™ cell counters
- FACS Analysis