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Recent Publications

1: McDougall WM**, Kandpal M, Perreira JM, Brass AL. Discovery of Zika Virus Dependency and Restriction Factors Using Flow-Based Arrayed CRISPR Screening for Identification of Targets (FACS-IT). Methods Mol Biol. 2020;2142:215-234. doi: 10.1007/978-1-0716-0581-3_17. PMID: 32367370. (** Co-Corresponding Author)

2: Yant SR, Mulato A, Hansen D, Tse WC, Niedziela-Majka A, Zhang JR, Stepan GJ, Jin D, Wong MH, Perreira JM, Singer E, Papalia GA, Hu EY, Zheng J, Lu B, Schroeder SD, Chou K, Ahmadyar S, Liclican A, Yu H, Novikov N, Paoli E, Gonik D, Ram RR, Hung M, McDougall WM, Brass AL, Sundquist WI, Cihlar T, Link JO. A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model. Nat Med. 2019 Sep;25(9):1377-1384. doi: 10.1038/s41591-019-0560-x. Epub 2019 Sep 9. PMID: 31501601; PMCID: PMC7396128. 3

: E X, Meraner P, Lu P, Perreira JM, Aker AM, McDougall WM, Zhuge R, Chan GC, Gerstein RM, Caposio P, Yurochko AD, Brass AL, Kowalik TF. OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7043-7052. doi: 10.1073/pnas.1814850116. Epub 2019 Mar 20. PMID: 30894498; PMCID: PMC6452726.

4: McDougall WM, Perreira JM, Hung HF, Vertii A, Xiaofei E, Zimmerman W, Kowalik TF, Doxsey S, Brass AL. Viral Infection or IFN-α Alters Mitotic Spindle Orientation by Modulating Pericentrin Levels. iScience. 2019 Feb 22;12:270-279. doi: 10.1016/j.isci.2019.01.025. Epub 2019 Jan 21. PMID: 30716700; PMCID: PMC6360249.

5: Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci- Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN. Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration. Cell Host Microbe. 2018 Sep 12;24(3):392-404.e8. doi: 10.1016/j.chom.2018.08.002. Epub 2018 Aug 30. PMID: 30173955; PMCID: PMC6368089.

6: McDougall WM, Perreira JM, Reynolds EC, Brass AL. CRISPR genetic screens to discover host-virus interactions. Curr Opin Virol. 2018 Apr;29:87-100. doi: 10.1016/j.coviro.2018.03.007. PMID: 29684735.

7: McDougall WM*, Savidis G*, Meraner P*, Perreira JM, Portmann JM, Trincucci G, John SP, Aker AM, Renzette N, Robbins DR, Guo Z, Green S, Kowalik TF, Brass AL. Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics. Cell Rep. 2016 Jun 28;16(1):232-246. doi: 10.1016/j.celrep.2016.06.028. Epub 2016 Jun 21. PMID: 27342126. (*Contributed equally)

8: Polevoda B, McDougall WM, Bennett RP, Salter JD, Smith HC. Structural and functional assessment of APOBEC3G macromolecular complexes. Methods. 2016 Sep 1;107:10-22. doi: 10.1016/j.ymeth.2016.03.006. Epub 2016 Mar 14. PMID: 26988126; PMCID: PMC5014647.

9: McDougall WM*, Polevoda B*, Tun BN*, Cheung M*, Salter JD, Friedman AE, Smith HC. RNA binding to APOBEC3G induces the disassembly of functional deaminase complexes by displacing single-stranded DNA substrates. Nucleic Acids Res. 2015 Oct 30;43(19):9434-45. doi: 10.1093/nar/gkv970. Epub 2015 Sep 30. PMID: 26424853; PMCID: PMC4627094. (*Contributed equally)

10: Perreira JM, Aker AM, Savidis G, Chin CR, McDougall WM, Portmann JM, Meraner P, Smith MC, Rahman M, Baker RE, Gauthier A, Franti M, Brass AL. RNASEK Is a V-ATPase-Associated Factor Required for Endocytosis and the Replication of Rhinovirus, Influenza A Virus, and Dengue Virus. Cell Rep. 2015 Aug 4;12(5):850-63. doi:10.1016/j.celrep.2015.06.076. Epub 2015 Jul 23. PMID: 26212330.

11: Smith HC, Bennett RP, Kizilyer A, McDougall WM, Prohaska KM. Functions and regulation of the APOBEC family of proteins. Semin Cell Dev Biol. 2012 May;23(3):258-68. doi: 10.1016/j.semcdb.2011.10.004. Epub 2011 Oct 6. PMID: 22001110; PMCID: PMC4017262.

12: McDougall WM, Smith HC. Direct evidence that RNA inhibits APOBEC3G ssDNA cytidine deaminase activity. Biochem Biophys Res Commun. 2011 Sep 9;412(4):612-7. doi: 10.1016/j.bbrc.2011.08.009. Epub 2011 Aug 11. PMID: 21856286; PMCID: PMC3171569.

13: McDougall WM, Okany C, Smith HC. Deaminase activity on single-stranded DNA (ssDNA) occurs in vitro when APOBEC3G cytidine deaminase forms homotetramers and higher-order complexes. J Biol Chem. 2011 Sep 2;286(35):30655-30661. doi: 10.1074/jbc.M111.269506. Epub 2011 Jul 7. PMID: 21737457; PMCID: PMC3162426.

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