Welcome to the Humphries Lab in the Division of Innate Immunity
Our Research Focus: How cell metabolism regulates inflammation and infectious disease
Metabolic regulation of cell death pathways
Mitochondrial reprogramming in “inflamm-aging”
Metabolic control of SARS-CoV2 infection
Therapeutic targeting of innate immune signaling pathways
Representative Publications
Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA. Succination inactivates gasdermin D and blocks pyroptosis. Science. 2020 Sep 25;369(6511):1633-1637.
The Humphries Lab is currently recruiting a post-doctoral fellow. If you are interested in joining our lab, please send a cover letter, CV, and contact information for three references to Dr. Fiachra Humphries.