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Manuscript Highlights

HIV-1 Protease

Manuscript Highlights 1 Ozen, A.*; Lin, K.-H.*;  Kurt Yilmaz, N.*,#; Schiffer, C.A.# “Structural Basis and Distal Effects of Gag Substrate Coevolution in Drug Resistance to HIV-1 Protease”, Proc. Natl. Acad. Sci. USA, Vol. 111, Iss. 45, 15993-15998 (2014). PMID: 25355911. (*joint first author) (#corresponding author).
Manuscript Highlight 2 Cai, Y.; Myint, W.; Paulsen, J.L.; Schiffer, C.A.; Ishima, R.; Kurt Yilmaz, N. “Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease” Journal of Chemical Theory and Computation, Vol. 10, Iss. 8, 3438-3448 (2014).
Manuscript Highlights 3 Khan, S.N.; Persons, J.D.; Paulsen, J.L.; Guerrero, M.; Schiffer, C.A.; Kurt Yilmaz, N.*; Ishima, R.* “Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV‐1 Protease and a Drug-Resistant Mutant in Solution by Nuclear Magnetic Resonance” Biochemistry, Vol. 57, Iss. 10, pp. 1652-1662 (2018). (*corresponding author)

 HCV NS3/4A Protease

Manuscript Highlight 4

Soumana, D.I.; Kurt Yilmaz, N.; Ali, A.; Prachanronarong, K.L.; Aydin, C.; Schiffer, C.A. “Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4 Inhibitor MK-5172”, ACS Chemical Biology, Vol. 11, Iss. 4, pp. 900-909 (2016).

Soumana, D.I; Kurt Yilmaz, N; Ali, A., Prachanronarong, K.L.; Schiffer, C.A. “Elucidating the Molecular Mechanism of Hepatitis C NS3/4A Protease Inhibitor Failure in Genotype 3”, J. Am. Chem. Soc, Vol. 138, Iss. 36, pp. 11850-11859 (2016).

 Influenza Targets

Manuscript Highlight 5

Prachanronarong, K.L.; Ozen, A.; Thayer, K.A.; Yilmaz, L.S.; Zeldovich, K.B.; Bolon, D.N.; Kowalik, T.F.; Jensen, J.D.; Finberg, R.W.; Wang, J.P.; Kurt Yilmaz, N.; Schiffer, C.A. “Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase” Journal of Chemical Theory and Computation, Vol. 12, Iss. 12, pp. 6098-6108 (2016).

Manuscript Highlight 6 Avnir, Y.; Prachanronarong, K.L.; Zhang, Z.; Hou, S.; Peterson, E.C.; Sui, J.; Zayed, H.; Kurella, V.B.; McGuire, A.T.; Stamatatos, L.; Hilbert, B.J.; Bohn, M.-F.; Kowalik, T.F.; Jensen, J.D.; Finberg, R.W.; Wang, J.P.; Goodall, M.; Jefferis, R.; Zhu, Q.; Kurt Yilmaz, N.*; Schiffer, C.A.*; Marasco, W.A.* Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope” Cell Reports, Vol. 21, Iss. 11, pp. 3243-3255 (2017). (*corresponding author)

Influenza Targets

Moise L, Girard B, Boyle C, Kurt Yilmaz N, Jang H, Schiffer C, Ross T, Martin WD, De Groot AS. “T cell epitope engineering: an avian H7N9 influenza vaccine strategy for pandemic preparedness and response” Hum Vaccin Immunother, Vol.14, Iss. 9, pp. 2203-2207 (2018).