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Our most recent publications:

Total: displaying 10 out of 15 results

Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication

Friday, March 15, 2024

Author(s): Jacob T Landeck,Joshua Pajak,Emily K Norman,Emma L Sedivy,Brian A Kelch

Source: The Journal of biological chemistry
Differences in clamp loader mechanism between bacteria and eukaryotes

Monday, December 11, 2023

Author(s): Jacob T Landeck,Joshua Pajak,Emily K Norman,Emma L Sedivy,Brian A Kelch

Source: bioRxiv : the preprint server for biology
A thermosensitive PCNA allele underlies an ataxia-telangiectasia-like disorder

Wednesday, March 29, 2023

Author(s): Joseph Magrino,Veridiana Munford,Davi Jardim Martins,Thais K Homma,Brendan Page,Christl Gaubitz,Bruna L Freire,Antonio M Lerario,Juliana Brandstetter Vilar,Antonio Amorin,Emília K E Leão,Fernando Kok,...

Source: The Journal of biological chemistry
Conformational dynamics control assembly of an extremely long bacteriophage tail tube

Wednesday, February 15, 2023

Author(s): Emily Agnello,Joshua Pajak,Xingchen Liu,Brian A Kelch

Source: The Journal of biological chemistry
Unexpected new insights into DNA clamp loaders: Eukaryotic clamp loaders contain a second DNA site for recessed 5' ends that facilitates repair and signals DNA damage: Eukaryotic clamp loaders contain a second DNA site for recessed 5' ends that facilitates repair and signals DNA damage

Sunday, September 18, 2022

Author(s): Huilin Li,Mike O'Donnell,Brian Kelch

Source: BioEssays : news and reviews in molecular, cellular and developmental biology
CaMKII binds both substrates and activators at the active site

Wednesday, July 13, 2022

Author(s): Can Özden,Roman Sloutsky,Tomohiro Mitsugi,Nicholas Santos,Emily Agnello,Christl Gaubitz,Joshua Foster,Emily Lapinskas,Edward A Esposito,Takeo Saneyoshi,Brian A Kelch,Scott C Garman,Yasunori Hayashi,Ma...

Source: Cell reports
A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA

Wednesday, June 22, 2022

Author(s): Xingchen Liu,Christl Gaubitz,Joshua Pajak,Brian A Kelch

Source: eLife
Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader

Friday, February 18, 2022

Author(s): Christl Gaubitz,Xingchen Liu,Joshua Pajak,Nicholas P Stone,Janelle A Hayes,Gabriel Demo,Brian A Kelch

Source: eLife
Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor

Saturday, May 29, 2021

Author(s): Joshua Pajak,Erik Dill,Emilio Reyes-Aldrete,Mark A White,Brian A Kelch,Paul J Jardine,Gaurav Arya,Marc C Morais

Source: Nucleic acids research
Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation

Friday, April 23, 2021

Author(s): Joshua Pajak,Rockney Atz,Brendan J Hilbert,Marc C Morais,Brian A Kelch,Paul J Jardine,Gaurav Arya

Source: Proceedings of the National Academy of Sciences of the United States of America
Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1

Tuesday, February 23, 2021

Author(s): Jennifer A Calvo,Briana Fritchman,Desiree Hernandez,Nicole S Persky,Cory M Johannessen,Federica Piccioni,Brian A Kelch,Sharon B Cantor

Source: Molecular cancer research : MCR
Exploring the Evolutionary History of Kinetic Stability in the α-Lytic Protease Family

Tuesday, January 12, 2021

Author(s): Charlotte F Nixon,Shion A Lim,Zachary R Sailer,Ivan N Zheludev,Christine L Gee,Brian A Kelch,Michael J Harms,Susan Marqusee

Source: Biochemistry
Structure of the human clamp loader reveals an autoinhibited conformation of a substrate-bound AAA+ switch

Thursday, September 10, 2020

Author(s): Christl Gaubitz,Xingchen Liu,Joseph Magrino,Nicholas P Stone,Jacob Landeck,Mark Hedglin,Brian A Kelch

Source: Proceedings of the National Academy of Sciences of the United States of America
A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry

Wednesday, February 05, 2020

Author(s): Janelle A Hayes,Brendan J Hilbert,Christl Gaubitz,Nicholas P Stone,Brian A Kelch

Source: The Journal of biological chemistry
Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure

Friday, October 04, 2019

Author(s): Nicholas P Stone,Gabriel Demo,Emily Agnello,Brian A Kelch

Source: Nature communications

In the News

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May 10, 2024

Dr. Brian Kelch Receives the Education Service Award, 2024

Dr. Brian Kelch received the Education Service Award in 2024! Learn more about his dedication to education in this blog post.

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Apr 24, 2024

Celebrating DNA Day!

Join us in celebrating the foundation of life as we know it by learning about innovative DNA-focused research in our department. Dr. Brian Kelch's lab is working to understand DNA-replication machinery across the tree of life in an effort to identify new candidate antibacterial targets.

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Latest INSERT LAB NAME HERE news as reported by the UMass Chan Communications Office

Faculty shine at Educational Recognition Awards ceremony, Last Lecture

April 26, 2024

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In the News

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Dr. Brian Kelch Receives the Education Service Award, 2024

Celebrating DNA Day!

Latest INSERT LAB NAME HERE news as reported by the UMass Chan Communications Office