May 10, 2024
Dr. Brian Kelch Receives the Education Service Award, 2024
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We determine how macromolecular machines work, with special emphasis on machines involved in virus assembly and in DNA replication and repair.
Understanding how these machines work will not only illuminate the underpinnings of these critically important cellular pathways, but can also lead to new targets for the development of novel cancer therapeutics, antivirals, and antibiotics.
The Kelch lab employs a diverse range of molecular techniques, including Cryo-EM, to dissect the structure and function of molecular machines.
We are a tight-knit group of scientists who value working hard and playing hard.
A thermosensitive PCNA allele underlies an ataxia-telangiectasia-like disorder
Magrino J, Munford V, Martins DJ, Homma TK, Page B, Gaubitz C, Freire BL, Lerario AM, Vilar JB, Amorin A, Leão EKE, Kok F, Menck CF, Jorge AA, Kelch BA.
J Biol Chem. 2023 May;299(5):104656. doi: 10.1016/j.jbc.2023.104656. Epub 2023 Mar 27. PMID: 36990216; PMCID: PMC10165274.
Conformational dynamics control assembly of an extremely long bacteriophage tail tube.
Agnello E, Pajak J, Liu X, Kelch BA.
J Biol Chem. 2023 Mar;299(3):103021. doi: 10.1016/j.jbc.2023.103021. Epub 2023 Feb 13. PMID: 36791911; PMCID: PMC10034513.
Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication
Landeck JT, Pajak J, Norman EK, Sedivy EL, Kelch BA.
J Biol Chem. 2024 Apr;300(4):107166. doi: 10.1016/j.jbc.2024.107166. Epub 2024 Mar 14. PMID: 38490435; PMCID: PMC11044049.
