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Department of Neurology

The  clinical and basic science research of the Department of Neurology is making exciting progress in areas such as amyotrophic lateral sclerosis, brain development, cognitive neuroscience and dementia, gene therapy in neurological disorders, multiple sclerosis, muscular dystrophy, Parkinson’s disease and movement disorders, shared decision making and neuro-prognostication, and traumatic brain injury.  

Clinical researchers are seeking to improve the clinical care and the outcomes of critically ill patients with neurological emergencies through cutting edge population research, clinical trials and qualitative research. 

Please access and learn more about our open positions that are posted to the right of the page. Please review below the current faculty hiring in the department:

Miguel Sena-Esteves, PhD, is an associate professor of neurology and a member of the Horae Gene Therapy Center. His laboratory at UMass Chan focuses on the development of adeno-associated virus (AAV) based gene therapies for lysosomal storage diseases, Huntington’s disease, ALS, FSHD and brain tumors. In addition, his laboratory develops novel AAV capsids to improve targeting, distribution and potent transduction of target tissues in these diseases, with a particular focus on the central nervous system.

Dr. Sena-Esteves leads the Tay-Sachs Gene Therapy Consortium with the focus to develop an AAV gene therapy and conduct the first-in-human clinical trial. He is also leading the pre-clinical development efforts for a GM1-gangliosidosis AAV gene therapy in collaboration with Lysogene. In 2011 he received the 'Outstanding New Investigator Award from the American Society of Gene & Cell Therapy (ASGCT)' for his many contributions to the field of gene and cell therapy. He has authored 88+ peer-reviewed publications and is inventor on several patent applications. Learn more about the staff: https://senaesteveslab.umassmed.edu/staff/