Michael P Czech

UMassMed Faculty Page

Inventions:

Title: Selective, siRNA-Mediated Knockdown of CB1 Receptors in Macrophages for the Treatment of Diabetes. UMMS13-52; Patent Pending.

  • Novel compositions and methods for the treatment of type 2 diabetes mellitus using glucan-encapsulated siRNA directed against human cannabinoid receptor 1 (CB1). The glucagon-encapsulated siRNA's specifically target phagocytic macrophages upon administration.

Title: Peptide-modified Glucagon Particles for Delivery of Therapeutic Cargoes. UMMS13-05; Patent Pending. 

Title: COMPOSITIONSANDMETHODSFOR DECREASING LEUKOCYTE EXTRAVASATION AND VESSEL FLUID LEAKAGE. UMMS12-52; 9,434,951. 

  • The technology provides novels compositions and methods for preventing formation of atherosclerotic plaques by administering inhibitory oligonucleotides, e.g. miRNA, that decrease Mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4).  This invention is based on the discovery that oligonucleotides that decrease the expression of Map4k4 mRNA in an endothelial cell reduce the induction of leukocyte adhesion molecules and reduce endothelial cell monolayer permeability.  Further provided are methods of using oligonucleotides targeting Map4k4 therapeutic agents for atherosclerosis.

Title: COMPOSITIONS AND METHODS FOR INDUCING MYOBLAST DIFFERENTIATION AND MYOTUBE FORMATION. UMMS12-29; Patent 9,506,033

Title: ENCAPSULATED NANOPARTICLES FOR NUCLEIC ACID DELIVERY. UMMS08-09; Patent 8,389,485  

  • This invention discloses a new method for delivery of nucleic acids, including agents for gene silencing (e.g. siRNAs). This new system is developed with exterior of yeast cell wall particle (YCWP) and interior comprising multilayer nanoparticle core with a payload complex. Using this technology, inventors have effectively shown siRNA can be delivered effectively in macrophages. 

 

Innovation TopicsRNAi/micro-RNA Therapy, Type II DiabetesMetabolic endocannabinoids, Gene Therapy, Inflammatory bowel diseaseIrritable bowel syndromeGene therapy improvement, AtherosclerosisCardiovascular disease/Cardiology, Research ToolsMuscle atrophyMyopathyChronic fatigue syndromeFibromyalgiaMuscular dystrophyFatigue fibromyalgiaSpinal muscular atrophyDuschenne Muscular Dystrophy (DMD)ClaudicationPolymyalgia rheumaticaRhabdomyolysisPolymyositis, Drug delivery vehicleMetabolic endocannabinoidsMetabolic inflammation