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Study published in Molecular and Cellular Proteomics

Date Posted: Monday, April 13, 2020

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Dr. Camila Martinez-Calejman builds off her recent study published in Nature Communications to further explore downstream mTORC2 signaling in brown adipocytes. Collaborating with a proteomics lab at the University of Washington, Camila examined time dependent changes in mTORC2 signaling following insulin stimulation in mature brown adipocytes.

The findings support her previous work identifying ATP-citrate lyase as an mTORC2-sensitive phospho-protein in brown adipocytes and uncover additional interesting features about the mTORC2 regulated proteome and phospho-proteome that may be relevant in type 2 diabetes and cancer.  

The full article titled "Proteome and phosphoproteome analysis of brown adipocytes reveals that RICTOR loss dampens global insulin/AKT signaling" in  the journal Molecular and Cellular Proteomics, April 1, 2020, can be found here.