News Archive - Guertin Lab

When Ameila isn't making cell lines, purifying proteins and running gels to address major questions in biomedical research, you may find her refereeing and organizing local, national and international rugby tournaments.  Recently, World Rugby appointed her head referee for matches in South Africa, California and Australia!  See Photos

Having healthy adipose tissue is essential for metabolic fitness. This is clear from the obesity epidemic, which is unveiling a myriad of comorbidities associated with excess adipose tissue including type 2 diabetes, cardiovascular disease, and cancer.  In this review, we discuss how recent advances in adipose tissue and mTOR biology are converging to reveal new mechanisms that maintain healthy adipose tissue, and discuss ongoing mysteries of mTOR signaling, particularly for the less understood complex mTORC2.

Congrats to "Dr." Chien-Min Hung who recently defended his thesis:  "mTORC2 promotes lipid storage and suppresses thermogenesis in brown adipose tissue in part through AKT-independent regulation of FoxO1."  Chien-Min is off to sunny San Diego, CA to join Dr. Reuben Shaw's lab at the Salk Institute for post-doctoral studies.  Good luck Chien-Min, we will miss you.

mTORC1 activity in mature adipocytes is essential for maintaining normal adipose tissue growth and its selective loss in mature adipocytes leads to a progressive lipodystrophy disorder and systemic metabolic disease that shares many of the hallmarks of human congenital generalized lipodystrophy.

mTORC2 functions in white adipose tissue as part of an extra-hepatic nutrient-sensing mechanism to control glucose homeostasis

The developmental origins of adipose tissue and the mechanisms controlling its expansion are only now beginning to be revealed. Although the tools and techniques used to study adipocyte development still need refinement, the emerging picture is that adipocyte development is complex.

The American Diabetes Association Research Foundation provides critical funding for diabetes research that accelerates the transition of scientific discoveries into practical, life-enhancing treatments and programs.

The purpose of this program is to enhance the integrated research and clinical training of promising predoctoral students, who are matriculated in a combined MD/PhD or other dual-doctoral degree training program (e.g. DO/PhD, DDS/PhD, AuD/PhD, DVM/PhD), and who intend careers as physician-scientists or other clinician-scientists.

The ironman is a 2.4 mile swim, 112 mile bike, and 26.2 mile run.

The American Heart Association/American Stroke Association is a national voluntary health organization dedicated to building healthier lives, free of cardiovascular diseases and stroke.  Since 1949, the American Heart Association has invested more than $3.9 billion in research to enhance our knowledge of cardiovascular diseases and stroke.