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Fundamental Metabolic Pathways

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Beyond our focus on metabolic alterations in disease, the Spinelli lab studies metabolic pathways at the fundamental level. This arm of our research program focuses on the discovery of (1)- new mammalian metabolites, (2)- novel metabolic pathways, and (3)- the tissue-specificity of utilization of metabolic pathways. We employ a combination of new technology that we develop and established techniques like stable isotope tracing and high resolution mass spectrometry to uncover fundamental metabolic pathways.