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New Data Published from the Guertin Lab About mTORC2 Signaling in Brown Adipocytes


Guertin Lab scientist, Camila Martinez-Calejman, PhD, built off her recent study published in Nature Communications from February, to further explore downstream mTORC2 signaling in brown adipocytes. Collaborating with a proteomics lab at the University of Washington, they examined time dependent changes in the mTORC2 signaling pathway, following insulin stimulation in mature brown adipocytes (fat tissue).

The findings support previous work from the Guertin Lab identifying ATP-citrate lyase as an mTORC2-sensitive phospho-protein in brown adipocytes. This newly published data uncovers additional interesting features about the mTORC2 regulated proteome and phospho-proteome that may be relevant in type 2 diabetes and cancer.  

The full article titled "Proteome and phosphoproteome analysis of brown adipocytes reveals that RICTOR loss dampens global insulin/AKT signaling" in  the journal Molecular and Cellular Proteomics, April 1, 2020, can be found here.

Dr. Martinez-Calejman is a post-doctoral fellow in the Guertin Lab. Her work is being funded by The American Diabetes Association. She's originally from Buenos Aires, Argentina, which is where she earned her degrees.

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