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New study of youth with type 1 diabetes connects ‘honeymoon period’ with lower LDL cholesterol

Difference in cardiovascular disease risk in type 1 diabetes points to need for earlier cholesterol monitoring in newly diagnosed children

Date Posted: Friday, May 18, 2018
By: Sandra Gray - UMass Medical School Communications

Benjamin Nwosu, MD - UMass Diabetes Center of Excellence

A new study by UMass Diabetes Center of Excellence physician-scientist Benjamin U. Nwosu, MD, found that children with type 1 diabetes who experienced a partial clinical remission, or “honeymoon phase,” had significantly lower LDL, or “bad” cholesterol, five years after diagnosis. 

The honeymoon is a brief period when some children with new onset type 1 diabetes are able to produce some insulin resulting in improved glucose control. The new data makes the case for initiating lipid profile monitoring when type 1 diabetes is first diagnosed, rather than waiting as long as five years, which is recommended by current care guidelines.

“This is the first study to delineate the differences in lipid profiles of children with type 1 diabetes after stratifying them by honeymoon status,” said Dr. Nwosu.  “We found that patients who went through the honeymoon period showed a lipid pattern similar to that of healthy children, as opposed to the nonremitters who had significantly higher LDL levels.”

Previous studies showed that children who are newly diagnosed with type 1 diabetes and begin to receive treatment may experience a period during which they are still secreting some insulin on their own and their blood sugars can temporarily be restored to normal or near normal levels.  However, patients who do not undergo this honeymoon may experience worse outcomes over the long term—including cardiovascular disease, which this study indicates may be presaged by high LDL cholesterol.

Published by PLOS ONE, the study of 123 children ages 9 to 14 with type 1 diabetes of four to five years duration, found significantly lower LDL cholesterol in those who underwent a honeymoon phase, after adjusting for patients’ age, blood sugar control, body mass index or onset of puberty.  This early divergence in the levels of bad cholesterol may explain the dichotomy in the prevalence of long-term complications in type 1 diabetes between remitters and nonremitters.  It also makes a case for early and targeted lipid monitoring in type 1 diabetes.

“We're the first group to report a significant difference in LDL cholesterol between remitters and nonremitters within the first five years of diagnosis of T1D in children,” said Nwosu.  “That opens a big area of research to explore the dichotomy further.”

View the complete study here

Related Article: Benjamin Nwosu confirms accuracy of simple method to detect honeymoon period in children newly diagnosed with type 1 diabetes  Pediatric diabetes expert urges use of easily calculated measure to monitor partial clinical remission