News from the UMass Diabetes Center of Excellence

Dr. Bandyopadhyay is a postdoc in the Brehm Lab. She's studying how and why the autoimmune attack occurs in people with type 1 diabetes. They've started transplanting human cells that were derived from stem cells, into their unique "humanized" mouse models. She conducts experiments to observe interactions between insulin-producing beta cells and immune cells from the same T1D patients.  VIDEO & STORY

The newly funded JDRF New England Center of Excellence research collaborative brings together leading scientists working to cure type 1 diabetes. Three simultaneous projects are being worked on to create a cell replacement therapy that would be invisible to the immune system, and provide insulin independence for people living with T1D. 
ARTICLE & VIDEO

Dr. Harlan kicked off the Stanford Diabetes Research Center Symposium celebrating the 100th anniversary of the purification & use of insulin as a life-saving diabetes treatment. His thorough retrospective describes important roles played by various scientists, including Nobel laureates. Four major themes in his presentation are: good ideas vs. brilliance; the roles that serendipity and persistence played; and unforeseen consequences of these incredible research accomplishments. VIEW VIDEO  

New insulin pumps, infusion devices, continuous glucose monitors and smartphone apps continue to become available. Learn about the latest technology and tools providing self-management options for people living with both type 1 diabetes and type 2 diabetes.  FULL ARTICLE

Tammy Nguyen, MD, PhD, is analyzing bone marrow to learn why diabetes patients with foot ulcers have a difficult time healing. She received the Vascular and Endovascular Surgery Society’s 2021 Early Career Faculty Research Grant designed to help new vascular surgical investigators initiate projects that will lead to additional funding. She's comparing immune cells from people with diabetes who have had amputations with nondiabetic patients who have had amputations for other reasons.  FULL STORY

Dr. Kim’s daughters Allison and Lauren are also considering careers in medicine and science. When Lauren’s summer research internship at Harvard Medical School was canceled due to the COVID-19 pandemic last year, the family quickly created the Diabetes Virtual Camp to connect students and experts in a virtual internship setting. After successful summer and fall sessions, they teamed up with the American Diabetes Association to support diabetes research, education and care. LEARN MORE

In addition to being a nurse practitioner for the Diabetes Center of Excellence at UMass Memorial Medical Center, Sean Collins, PhD, NP, is also has a decorated military career. Air National Guard Brigadier General Sean Collins has been named a member of the Board of Trustees for the Soldiers’ Home in Holyoke. He recently served three months at the Pentagon addressing COVID issues in the early days of the pandemic.  FULL STORY

Newly published research from the Davis Lab at the UMass Diabetes Center of Excellence explains a discovery that could lead to a potential therapy for type 2 diabetes and other metabolic diseases. LEARN MORE

Shianne was nominated by a colleague at the UMass Diabetes Center of Excellence via UMatter Central, a systemwide online recognition platform which gives UMass Memorial caregivers the opportunity to show appreciation for fellow caregivers.  She works full time in the diabetes clinic, while raising three children, ages 6, 13 and 15, and also attending nursing school.  MEET SHIANNE

The Joseph “Nuzzy” Nozzolillo Memorial Foundation added a $17,500 donation to their ongoing support of the UMass Diabetes Center of Excellence, raising their three-year total to $40,000.  The third annual Joe “Nuzzy” Nozzolillo Memorial Golf Tournament was held in September, following a socially distant outdoor “Rockin’ for Nuzzy” fundraiser concert over the summer. STORY & PHOTOS

Dr. Samir Malkani has been named Interim Chief of Diabetes, UMass Memorial Department of Medicine.  Dr. Malkani is a Professor of Medicine at UMass Medical School and began treating people living with diabetes at UMass Memorial in 1993 as a postdoctoral fellow.  Since 2001, he's been spending part of his week at Milford Regional Medical Center and was instrumental in building the UMass DCOE Community Diabetes Partnership Program.  Dr. David Harlan will continue serving as co-director of the DCOE, placing an emphasis on his ongoing type 1 diabetes research.  LEARN MORE

Research at UMass Medical School shows low levels of a protein commonly seen in screening tests during the first trimester of pregnancy is associated with adipose tissue remodeling, glucose resistance and gestational diabetes in pregnant women. The study, published in Science Translational Medicine, outlines a new role for pregnancy-associated plasma protein A, known as PAPPA, in gestational diabetes, with translational potential as both a diagnostic tool and therapeutic target.  FULL STORY

The laboratory of Louis M. Messina, MD, has received grant funding from the National Institutes of Health (NIH) to test a novel therapy they’ve developed to treat wounds in older adults living with type 2 diabetes.  The Messina Lab already developed and patented a biotherapeutic, which they're now testing in our unique humanized mouse models.  FULL STORY

Scientists in the Czech Lab and Corvera Lab at UMass Medical School are using the gene editing tool CRISPR to alter DNA and modify gene function - and developing new methods to modify human fat cells in vitro, then transplanting them as a potential therapy for type 2 diabetes and obesity.  LEARN MORE

Victoria Andersen is a registered dietitian, licensed nutritionist and certified diabetes care & education specialist at the UMass Memorial Diabetes Center of Excellence. She uses her diverse training to help people living with type 1, type 2 and gestational diabetes customize a healthy eating lifestyle to keep their blood sugars within target range. Her long road to Massachusetts went through Minnesota and Seattle.  MEET VICTORIA 

People with extra fat around their belly are more at risk of developing type 2 diabetes than those who have fat in the lower body. The Corvera Lab is studying how the development and function of fat cells differ in people with and without diabetes. They examine human fat from different locations in the body to study cells which become fat cells. Understanding the differences in genes expressed in these cells from abdominal fat or gluteal fat and how they become different types of fat cells will help elucidate how different fat depots form, and if they vary between people with and without type 2 diabetes. It will also help explain why lower body fat is beneficial, and maybe recapitulate these beneficial effects in ways that can improve health.  LEARN MORE

Newly published research in the Guertin Lab at the UMass Diabetes Center of Excellence knocks out a gene, specifically in a precursor cell population, that gives rise to new fat cells, to understand how to make a healthy fat cell. They're studying a signaling pathway called mTOR Complex 2 (mTORC2). A key regulatory input was discovered that helps to establish not only insulin sensitivity, but the ability of fat tissue to use insulin to take up and store energy as lipids. For the first time, this data establishes mTORC2 as a key regulator of a developing fat cell.  FULL STORY

Taylor splits her time helping people manage diabetes at both the UMass Diabetes Center of Excellence on the University campus in Worcester, as well as in northern Massachusetts at Heywood Hospital in Gardner. She enjoys helping them understand the barriers preventing healthy blood sugars, and putting together a plan to overcome those obstacles. she takes great pride in her patients' results. MEET TAYLOR

Nobel Laureate Craig Mello presented the annual Mello Scholars awards at a socially distanced ceremony at UMass Medical School. The event recognizes graduate students in the Program in Molecular Medicine with outstanding track records and bright futures. The award comes with one year of funding. One of this year’s recipients is a member of the Czech Lab at the UMass Diabetes Center of Excellence. Learn more about this year's honorees here.

Lindsey was diagnosed with type 1 diabetes at 18 years old during her senior year of high school. Transitioning to college life was stressful while still learning to manage T1D with insulin injections & blood sugar checks all day. After freshman year at Suffolk University she decided to pursue a career as a nurse practitioner specializing in helping people with diabetes. Lindsey transferred to UMass Boston where she completed her nursing degree. She worked as a full-time nurse for 11 years and became a certified diabetes educator to help people manage diabetes. While working full-time, Lindsey earned her Masters in Nursing degree completing the Nurse Practitioner Program. Today she educates patients living with diabetes who are admitted to UMass Memorial hospitals.  MEET LINDSEY

The UMass Diabetes Center of Excellence and Division of Endocrinology welcomed Clifford Rosen, MD, to present at Endocrine Grand Rounds. Dr. Rosen is the director of clinical and translation research at Maine Medical Center Research Institute, and professor of medicine at Tufts University School of Medicine. His ties to UMass Medical Center date back to his medical residency during the late 1970’s, where a long friendship and working relationship was formed with the late Dr. Lewis Braverman. Learn more about the impressive career of Dr. Braverman and the many lives he touched. Watch Dr. Rosen's Endocrinology Grand Rounds research talk "A New Counter-Regulatory Hormone During Exercise: The Story of Irisin."  ARTICLE & VIDEO

The American Diabetes Association launched #HealthEquityNow, a national platform to ensure all 122 million Americans living with diabetes and prediabetes have access to necessary health resources. The UMass Diabetes Center of Excellence continues to hear people complain that insulin is too expensive. Many have admitted to sometimes skipping doses to make it last longer.  FULL STORY 

Jessin has been working as a nurse practitioner at the UMass Diabetes Center of Excellence since 2015. She’s a member of the Inpatient Blood Glucose Management care team, who works with patients living with diabetes while they’re being treated at UMass Memorial hospitals. Learn why she chose diabetes, the differences between inpatient and outpatient diabetes care, and her typical day at work.  MEET JESSIN

The location of body fat varies in people and too much fat in the
belly area is a risk factor for diabetes. The purpose of this
research is to characterize how fat cells from the abdomen and
buttock regions are different and to study how these cells are
different in people with type 2 diabetes.  LEARN MORE

Type 2 diabetes research in the laboratory of Dr. Jason Kim at the UMass Diabetes Center of Excellence, in a collaborative project led by Dr. Anath Shalev at the University of Alabama at Birmingham and her research team who had discovered a small molecule SRI-37330, have unveiled an exciting new process by which this compound effectively rescues mice from obesity-induced diabetes.  Compared to currently available therapies it could provide an effective new approach to treating type 2 diabetes.  LEARN MORE

Prior to completing their studies at University of Massachusetts Medical School, Dr. Ashley Millette Cote and Dr. Alexandria Capozza completed a capstone research project which analyzed the effectiveness of Diabetes Prevention Programs in Massachusetts.  They also developed an elective class at the medical school to teach future students about the best care available for people living with prediabetes and type 2 diabetes.  FULL STORY

Scientists at the UMass Diabetes Center of Excellence continue to gain new knowledge of type 1 diabetes by studying human tissues and human cells, to recreate the disease in our unique humanized animal models.  Newly published research describes our collaboration with the Melton Lab at The Harvard Stem Cell Institute.  Scientists were recently able to model type 1 diabetes autoimmunity using patient’s blood and stem cell derived beta cells.  LEARN MORE

Uncontrolled high blood sugar in young people with type 1 diabetes is common during puberty. Dr. Nwosu led a newly published study in the Journal of Pediatric Endocrinology and Metabolism that examined blood glucose data of pediatric T1D patients at the UMass Memorial Diabetes Center of Excellence. Results include a significantly lower A1c after one year, in the group that used a continuos glucose monitor.  LEARN MORE

UMass Diabetes Center of Excellence scientist Sally Kent's lab is credited with uncovering new information about how autoreactive T cells target beta cells in pancreatic islets. Dr. Kent is encouraged her breakthrough will contribute to the design of therapies for people living with type 1 diabetes. She's one of the authors of a published Perspective article in the July 2020 journal Diabetes which updates and reappraises what scientists have found over the past 30 years examining autoreactive T cell response in T1D.  FULL STORY

Amy Darukhanavala, MD, a pediatric diabetes physician at UMass Memorial’s Diabetes Center of Excellence, led a study comparing the success of continuous glucose monitoring at diabetes summer camp versus at home prior to camp. The research examined blood sugar data and quality of life, based on how the children felt about their diabetes in both settings.  STUDY RESULTS

Enteroviruses encompass a group of viruses that give rise to infectious illnesses which are usually mild. However, if enteroviruses such as coxsackievirus infect the central nervous system or heart, they can cause serious illness. Enteroviral infections are also associated with T1D, but how they contribute to this disease is not well understood. Jennifer Wang's lab is using stem-cell derived beta cells to study virus-driven immunology and beta cell dysfunction, with the ultimate goal of new treatments.  FULL STORY

Thanks to support from the Helmsley Charitable Trust through their Diabetes Data Innovation Initiative, the UMass Memorial DCOE is developing digital health solutions to efficiently collect data and train administrative staff to implement the systems. FULL STORY

The U.S. Food and Drug Administration asked five pharmaceutical companies to voluntarily recall a limited supply of metformin extended-release (ER) tablets 500 mg. Recent tests revealed high levels of N-nitrosodimethylamine (NDMA), which is believed to cause cancer. FDA testing has not shown NDMA in immediate release (IR) metformin products, which is the most commonly prescribed type of metformin. LEARN MORE

Virtual telemedicine has been considered by many over the years to be well-suited for diabetes care. A recent study shows better A1c reduction in people who received telehealth care compared with typical in-person appointments. UMass Memorial patients who have received remote diabetes care during the coronavirus pandemic have been overwhelmingly positive about the process. Another published study claims people with type 1 diabetes have combined telehealth and technology with proper blood glucose management and monitoring to achieve better outcomes during the pandemic, as patients avoid in-person visits. FULL STORY

UMass Diabetes Center of Excellence co-director David Harlan, MD, participated in newly published research that further characterized pancreases from adult donors with type 1 diabetes compared with similarly aged donors without diabetes. The study found the pancreases from those with both longstanding and recent-onset T1D to be approximately 45% smaller than pancreases from donors without diabetes.  To learn more about the study and its other findings, check out the FULL STORY

Type 2 diabetes research in the UMass Diabetes Center of Excellence laboratory of Michael Czech, PhD, is studying the behavior and function of various fat cells, with the goal of improving metabolism for a potential obesity therapy. New data from one of their recent studies was published in the journal Cell Reports.  FULL STORY

The Food and Drug Administration recently allowed continuous glucose monitors to be used in hospitals during the pandemic to help health care workers monitor diabetes patients while reducing their own exposure to the coronavirus. This week, UMass Memorial began using them to monitor the blood sugar of UMass Memorial's COVID-19 patients with diabetes. In recent years, the UMass Diabetes Center of Excellence has revolutionized blood glucose management for all people living with diabetes who are admitted to Worcester’s UMass Memorial hospitals.  LEARN MORE

Alan Derr was named the Cammett Scholar for type 1 diabetes research, supported by a generous gift from UMass Diabetes Center of Excellence Visiting Advocacy Committee member John Cammett. Alan's role as a bioinformatician is to analyze the vast volume of data generated during the study of human insulin producing beta cells and the immune cells that attack human islets in people living with diabetes. FULL STORY

Type 2 diabetes metabolism research in the Guertin Lab examined time dependent changes in the mTORC2 signaling pathway in mature brown adipocytes (fat tissue). LEARN MORE

David Harlan, MD, interviewed Nobel Prize laureate Wally Gilbert, PhD, 40 years after the first human insulin for diabetes treatment was genetically engineered, thanks in part to his pioneering work in DNA sequencing. Dr. Gilbert is now an accomplished artist and after the interview they toured his impressive art studio in Boston. WATCH THE VIDEO

A new program within the UMass Diabetes Center of Excellence is tracking patients at-risk for negative outcomes due to gaps in care by identifying their difficulties and guiding them towards available services and resources to control their diabetes. The ultimate goal is to prevent or reduce the risk of complications, lower healthcare costs, and improve quality of life by encouraging self-care diabetes management. LEARN MORE

The American Diabetes Association continues to recommend screening people living with type 1 diabetes for psychosocial health concerns. The UMass Memorial Diabetes Center of Excellence is one of few diabetes clinics in the country which currently employs multiple health psychologists on the diabetes care team. The pediatric diabetes care team at UMass Memorial developed and implemented a successful pilot screening program. The results were published in Journal of Pediatric Psychology.  FULL STORY

The UMass Diabetes Center of Excellence established The Glass Family Fellowship in Diabetes Research, through a gift from Scott and Patricia Glass. It was awarded to Richard A. Siller, PhD, a postdoctoral research fellow in the Maehr Lab. He's eager to collaborate with his fellow lab members to work toward creating a fully functional human thymus over the the next two years at the University of Massachusetts Medical School.  FULL STORY 

A new study in the Davis Lab on causes of metabolic syndrome was published in The Proceedings of the National Academy of Sciences, the official journal of the National Academy of Sciences. Data obtained from this research provides insight into some type 2 diabetes risk factors including high blood glucose and obesity.  READ MORE

A study by Camila Martinez Calejman, PhD, published in the journal Nature Communications revealed an unexpected link between mTOR signaling and the synthesis of Acetyl-CoA, a molecule with critical roles in carbohydrate and lipid metabolism and the epigenetic control of gene expression.  It describes the importance of this link in brown adipose tissue, but the implications may extend to understanding other aspects of type 2 diabetes and cancer.  FULL STORY

Diabetes Center of Excellence scientists are part of the UMass Medical School Metabolic Network that connects the many laboratories and researchers who study various facets of metabolism and metabolic regulation on campus. It provides another opportunity to learn new biology, find potential collaborators and advance new technologies.  LEARN MORE 

In a clinical trial the Maehr Lab is creating human thymus glands using stem cells from the blood of volunteer participants. They'll be inserted into our humanized immune systems, along with insulin producing beta cells and immune cells created from the stem cells of those same blood donors. This will allow our scientists to study the interaction between an individual’s own cells, to investigate how and why the autoimmune attack is taking place. Once it’s determined what’s causing type 1 diabetes, we can then begin to test therapies within our humanized immune models.  LEARN MORE

A new technique to study human cells and tissues was recently developed at the UMass Diabetes Center of Excellence. It’s another step forward in the continued effort to examine the insulin producing beta cells of humans living with type 1 diabetes and to learn more about the autoimmune attack associated with the disease. The new method allows our scientists to recover and further examine sufficient amounts of living human cells that they previously transplanted into our novel human immune models.  LEARN MORE 

Type 2 diabetes research in the laboratory of Michael Czech, PhD, includes studying the behavior and function of the various cells that make up adipose tissue, with a goal of improving systemic metabolism in obesity.  They contributed some of their RNAi technology to a study published in The Journal of Immunology.  FULL ARTICLE  

Sally C. Kent, PhD, has been named the George F. and Sybil H. Fuller Foundation Term Chair in Diabetes. Dr. Kent studies autoimmune response in type 1 diabetes. Her lab is credited with uncovering new information on how autoreactive T cells target beta cells in islets, a breakthrough that will contribute to the design of therapies for people with type 1 diabetes.  FULL STORY

Guertin Lab graduate student Wen-Yu Hsiao presents an interesting perspective based on recent findings about what makes a fat cell “healthy” and why.  Their research examines how the metabolism of adipocytes impacts blood glucose and insulin resistance especially in people living with obesity and/or type 2 diabetes.  READ MORE

Rachael is a certified pediatric nurse and certified diabetes care and education specialist (CDCES). Her interest in working with children living with diabetes began while she was first studying to become a nurse at Worcester State University, and spent time at a camp for kids with diabetes. The most gratifying part of her job is helping families get through the overwhelming and frightening process of diagnosis, to the first few clinic appointments and eventually feeling confident that they can manage the disease.  READ MORE

The UMass Diabetes Center of Excellence education workshops use Conversation Maps® to teach a variety of diabetes topics to help people make lifestyle changes as part of their self-management.  LEARN MORE

People living with type 1 and type 2 diabetes, even when well-managed, are at high risk of serious flu complications. September or October is considered the best time to get the vaccine. The flu shot is a safe and effective way to prevent or reduce the severity of previously mentioned complications.  LEARN MORE

Dr. David Harlan welcomed his longtime friend and fellow distinguished physician/scientist, Carl H. June, MD, to speak at the University of Massachusetts Medical School Department of Medicine Grand Rounds. They worked closely throughout the 1990's when they led the U.S. Navy’s “Immune Cell Biology Program." Dr. June is director of the Center for Cellular Immunotherapies at the University of Pennsylvania Medical School, and is best known for his pioneering work developing CAR T-cell therapy for the treatment of leukemia. FULL VIDEO

The Messina lab is studying impaired wound healing resulting from type 2 diabetes. They've found that diabetes impairs wound healing by causing an injury to blood stem cells that affects a particular white blood cell which is the most important cell in the body’s response to a diabetic ulcer.  Loss of limbs is a major fear of people with uncontrolled blood sugars. This research is exploring a blood stem cell-based therapeutic approach to reverse what is one of the most feared complications of diabetes.  FULL STORY 

Dr. Corvera’s laboratory determined that there are more types of fat cells in the human body than originally thought. Prior research had shown two types of fat cells, white and beige. This new research uncovered at least five types of human fat cells which play different roles in how they affect metabolism.  They're now investigating human cell therapy, which consists of using the body’s own cells to increase metabolism, as a possible treatment for type 2 diabetes or its complications.  FULL STORY

A new study at UMass Medical School is designed to develop a questionnaire about peer mentor support for parents of children with type 1 diabetes, as well as young adults who are living with T1D. A peer mentor is a person who provides support and advice on diabetes management. Participants in this study will receive a $25 gift card as a thank you for partaking in each part of the study.  LEARN MORE

Dr. Lopez joins the UMass Diabetes Center of Excellence specializing in child and family health psychology. She provides bilingual therapy (English and Spanish) and enjoys helping people of all ages to achieve measurable outcomes with type 1 or type 2 diabetes. She's helped many people to lower their blood sugars into a healthy range. The UMass DCOE is one of a small number of diabetes centers within the U.S. that has health psychologists as part of the care team.  LEARN MORE  

The goal of this research is to create an implantable cell replacement device to be used as a therapy for people living with type 1 diabetes. Insulin-producing beta cells would be encapsulated in the device to protect the cells from the autoimmune attack, while also allowing those protected cells to survive and function.  FULL STORY

Fernanda Costa, RN, joins the UMass Diabetes Center of Excellence with years of experience serving the Hispanic type 2 diabetes community. She’s fluent in Spanish and Portuguese, which will allow her to speak to our Hispanic and Latino patients in their native language. Costa takes pride in the fact that she has successfully educated many in this high-risk population, helping them to lower their A1c’s, control their blood sugars, and decrease their risk of future health complications.  FULL STORY

The second annual Joe “Nuzzy” Nozzolillo Memorial Foundation golf tournament raised $12,000 for the UMass Diabetes Center of Excellence, surpassing their inaugural donation of $10,500.  Joe's family and friends are grateful for the care he received and they want to help other people in the area living with diabetes. They presented the check while touring the UMass DCOE research labs  LEARN MORE

Parents of young children living with type 1 diabetes were asked about the pros and cons of using continuous glucose monitors.  They described the benefits and the challenges.  We asked members of our pediatric diabetes care team their thoughts.  LEARN MORE  

Dr. Warnock joins the UMass Diabetes Center of Excellence following 12 years of service in the United States Navy. She specializes in both type 1 and type 2 diabetes management, insulin pump therapy, obesity, weight gain and regain. In 2018 she was deployed for a three-month humanitarian mission in Guatemala and Honduras, where she contributed to 15,500 patient encounters. Learn about what attracted her to UMass Memorial.  FULL STORY

Dr. MacGregor conducted the first known study of its kind to evaluate the clinical benefit of having a behavioral psychologist who specializes in diabetes working within a diabetes clinic.  Read about why she believes it can potentially make a substantial positive impact on people’s diabetes management and outcomes.  FULL STORY

Dr. Harlan was invited to speak at the Endocrine Society's Fellows Series: Type 1 Diabetes Care and Management.  His talk titled "Going Beyond Insulin: Emerging Options for T1D" presented options beyond insulin therapy for people living with diabetes, including GLP-1 and SGLT use.  LEARN MORE

UMass Memorial offers convenient eye exams for patients with diabetes.  The 5-day a week clinic provides easy access to annual eye exams for our adult and pediatric diabetes patients while they’re already on campus for their diabetes related appointments.  LEARN MORE

The UMass DCOE was well represented at the American Diabetes Association’s 79^th Scientific Sessions in San Francisco, California.  Our team included award recipients, speakers and research presenters.  LEARN MORE

The second annual Herman G. Berkman Diabetes Clinical Innovation Fund grant has been awarded to Leslie J. Domalik, MD and co-investigator Asem Ali, MD.  Read about their project, intended to improve blood glucose control for all patients admitted to UMass Memorial hospitals who are living with diabetes.  FULL STORY

Laura Alonso, MD, The George F. and Sybil H. Fuller Term Chair in Diabetes, Director of Beta Cell Biological Studies at the UMass Diabetes Center of Excellence, has been elected to the American Society for Clinical Investigation (ASCI).  One of the nation’s oldest and most prestigious medical honor societies, ASCI supports the work of top physician-scientists whose biomedical research translates findings in the laboratory to the advancement of clinical practice.  LEARN MORE

Studying the islets of people with type 1 diabetes, the laboratories of David Harlan, MD and Sally Kent, PhD definitively put to rest a three decades old debate about whether beta cells express important immune genes called “human leukocyte antigen class II” (HLA Class II).  LEARN MORE 

Nancy Sidhom has been a nurse practitioner at the UMass Diabetes Center of Excellence since 2013. She enjoys partnering with patients to help them better manage daily life with diabetes.  Nancy has a passion for proper nutrition and exercise, and strongly believes they are the foundation to proper diabetes self-management.  LEARN MORE  

A study published by the laboratory of Laura C. Alonso, MD, confirms the fidelity of a widely used technique to measure beta cell replication, despite doubt by some in the field.  The ultimate goal of Laura Alonso's research is to determine approaches to make more beta cells, so as to prevent or treat diabetes.  LEARN MORE

A new study by Benjamin Nwosu, MD, correlates the phenomenon known as partial clinical remission in children newly diagnosed with type 1 diabetes with cholesterol levels when they reach puberty.  FULL STORY

The Certified Child Life Specialist at the UMass Memorial Diabetes Center of Excellence supports children and families beginning at the very first office appointment. She works closely with the pediatric diabetes care team to provide age appropriate support and interventions.  LEARN MORE

Apoptosis of CD8 T cells is an essential mechanism that maintains immune system homeostasis, prevents autoimmunity, and reduces immunopathology.  Research from the Brehm, Greiner and Davis laboratories at the UMass Diabetes Center of Excellence, was published in The Journal of Immunology.  FULL STORY

The laboratory of Silvia Corvera, MD, was featured on WCVB-TV/ABC in Boston and WJAR-TV/NBC of Providence about their research into transforming white fat into beige fat, to harness its ability to burn energy, accelerate metabolism and fight disease.  FULL STORY AND VIDEO 

Rachel Stamateris, an MD/PhD candidate at University of Massachusetts Medical School, has been awarded a prestigious Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship for dual-doctoral degree students, from the National Institute of Diabetes and Digestive and Kidney Diseases.  Her fellowship experience is intended to enhance Rachel’s integrated research and clinical training as predoctoral student.  Over the next four years, this award will help to sponsor her research and promote her development into a productive, independent physician/clinician-scientist.  READ MORE

Isolating donated islets from a young man who had been treated for 17 years for presumed T1D, scientists found a rare genetic defect had caused his beta cells to function improperly.  Findings were published in The Journal of Clinical Investigation.  LEARN MORE

A plan to increase competition and bring down the price of insulin was presented this week by The Food and Drug Administration.  It includes recharacterizing insulin as a biologic instead of a drug, to help drugmakers make biosimilar insulins available to people living with diabetes.  Three companies currently control 90% of the global insulin market and produce all the insulin used in the United States.  FULL STORY

The UMass DCOE is among a few in the world studying human beta cells, the insulin producing cells found only in the pancreas.  The lab of DCOE co-director Dale Greiner, PhD, provided unique immunodeficient mice that allowed for the in-vivo imaging studies which identified a new biomarker for beta cells.  Findings are published in Cell Metabolism, December 2018.  FULL STORY

The Brehm and Greiner labs study human immune responses pathways for potential type 1 diabetes therapies.  "Lack of acute xenogeneic graft-versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression," published in The FASEB Journal.   LEARN MORE

The First Annual Joe “Nuzzy” Memorial Golf Tournament raised $10,500, which was generously donated to the UMass Memorial Diabetes Center of Excellence (DCOE), to be used for continued patient care.  The family wants the money to help others being treated for diabetes at UMass Memorial.  They recently toured our research laboratories, and were impressed with what they saw.   
FULL STORY

Silvia Corvera, MD, and Michael Czech, PhD, are investigating whether technologies developed in their labs will harness beige fat’s ability to burn energy and accelerate metabolism in order to improve the body’s response to sugar and lower blood glucose levels.  READ MORE

One third of hospitalized patients have diabetes. Our inpatient team sees the many who already have diabetes while undergoing surgeries or procedures, or are being treated for another chronic illness or health complication. They also work closely with people getting diagnosed with diabetes for the first time, teaching everything needed to leave with “diabetes survival skills.” Our inpatient team ensures a smooth transition home by coordinating medication prescriptions and follow-up appointments.  LEARN MORE

Infectious disease and immunology expert Jennifer Wang, MD hopes to move closer to better understanding type 1 diabetes by working with a new animal model to identify pathways which could be stopped in order to prevent the disease from developing.  FULL STORY

Fat tissue has a remarkable capacity for growth. David A. Guertin, PhD, explains why his latest research of a fat-precursor cell which unexpectedly functions to suppress adipocyte production, is exciting to the future of combating obesity.  READ MORE

Words used to describe something shapes the way others perceive and value that thing.  The culture in diabetes tends to be the disease defines the person, such as, “he/she is a diabetic.”  Changing that language to “he is living with diabetes” or “she is thriving with her diabetes care” can make a world of difference.  “A1c and blood glucose numbers should simply be used as data to devise a treatment plan and action plan.  Not a definition of the person,” says Kristin L. MacGregor, PhD, a behavioral psychologist at the UMass Diabetes Center of Excellence. “The truth is, you have the power to manage the disease, it doesn’t control you.”  READ THE ENTIRE ARTICLE

Diabetes education has been shown to lower A1c by as much as 1% (similar to adding a medication but without the side effects). Research shows that people who have received diabetes education are more likely to utilize primary care and preventative services, take medications as prescribed and control their blood glucose, blood pressure, and cholesterol levels. As a result, those people have lower health costs.  The UMass Memorial Diabetes Center of Excellence offers an extensive education program covering a variety of topics. Both one-on-one sessions and group workshops are available.  LEARN MORE 

Thymus development research in the lab of René Maehr, PhD was featured as the cover story in Immunity.  Single-cell RNA sequencing was used to illustrate a framework for biological discovery and molecular analysis of thymus organogenesis (the production and development of the organ).  READ MORE 

Many patients do not understand the role and capabilities of a nurse practitioner (NP) when it comes to diabetes care.  NPs are taught both the medical model and the nursing model of care.  The scope of practice of a nurse practitioner varies from state to state. Meet Christine and learn how she provides care to patients at the UMass Diabetes Center of Excellence.  LEARN MORE

The price of insulin nearly tripled between 2002 and 2013. The American Diabetes Association recently provided new recommendations for improving insulin access and affordability. Their policy statement addresses four key areas.  READ MORE

New research by UMass DCOE physician-scientist Benjamin Nwosu found that children with type 1 diabetes who experienced a “honeymoon phase,” had significantly lower LDL or “bad” cholesterol, five years after diagnosis. Children who do not undergo this honeymoon may experience worse outcomes over the long term—including cardiovascular disease.  READ MORE

The American Diabetes Association recommends including behavioral health professionals on diabetes care teams.  The UMass Diabetes Center of Excellence is one of few diabetes centers in the country that currently has behavioral psychologists on staff.  One of them, Kristin L. MacGregor, PhD, was published in Diabetes Care, examining exactly how close diabetes healthcare in the United States really is to meeting those recommendations.  READ MORE

David Harlan, MD, co-director of the UMass Diabetes Center of Excellence, was quoted in a New York Times article about a new study published in the journal Pediatrics which found that children and adults with type 1 diabetes who followed a very low-carb, high-protein diet, combined with insulin at smaller doses than typically required on a normal diet, had “exceptional” blood sugar control and low rates of major complications.  READ THE FULL ARTICLE

Roger J. Davis, PhD was elected into the National Academy of Sciences.  Membership in the NAS is one of the highest honors bestowed upon a scientist in the United States.  He joins four UMass Medical School colleagues who have received membership in recognition of their for outstanding contributions to original research.  His work to explain the molecular mechanism by which inflammation contributes to diabetes, cancer and stroke has been among the most important in this field for more than two decades.  READ MORE

Dr. Laura Alonso hosted the Boston Ithaca Islet Club Annual Meeting at the UMass Diabetes Center of Excellence. The weekend conference was attended by scientists from academic centers around the northeast United States and Canada, who research pancreatic islet function, development, growth, immunology and transplantation.  READ MORE

Although diabetes research centers are well defined by National Institutes of Health, there is no clear definition for clinical Diabetes Centers of Excellence (DCOE).  Dr. David Harlan, co-director, UMass Diabetes Center of Excellence collaborated on an article published in The Journal of Clinical Endocrinology & Metabolism, in which they propose a framework to guide advancement for DCOE.  READ MORE

To better understand the functional and molecular properties of islets from donors with T1D, this research used an approach that studied the pancreas and isolated islets from the same donor, allowing better analysis of the development, properties and behavior of the islets.  LEARN MORE 

Nancy Morris, MD, Adult Nurse Practitioner in the UMass Diabetes Center of Excellence, won the Excellence in Nursing Education Award.  The American Nursing Association of Massachusetts honors nurse educators for teaching, research and practice, recognizing innovative approaches to facilitate learning and professional development. READ MORE