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Gestational Diabetes: Conversations Between the Placenta and Adipose Tissue

Tiffany A. Moore Simas, MD, MPH, MEd, FACOG

Chair, Department of Obstetrics & Gynecology, UMass Medical School

Silvia Corvera, MD

Chair in Diabetes Research, Director, MSTP (MD-PhD) Program, UMass Medical School

The talk was co-presented at UMass Endocrinology Grand Rounds via Zoom on May 25, 2021.  They were introduced by Dr. David Harlan.

At the conclusion of this video, you'll understand:

  • The prevalence and current care standards for gestational diabetes screening, diagnosis and treatment 
  • Anatomic and physiologic adaptions of pregnancy that lead to increased adipose tissue and insulin resistance 
  • Human data and mouse models that informed a novel role for PAPP-A in gestational diabetes

VIDEO

Learn about Drs. Moore Simas and Corvera’s study

"PAPPA-mediated adipose tissue remodeling mitigates insulin resistance and protects against gestational diabetes in mice and humans"

Read about their study published in Science Translational Medicine that outlines a new role for pregnancy-associated plasma protein A, known as PAPPA, in gestational diabetes, with translational potential as both a diagnostic tool and therapeutic target.


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David M. Harlan, MD - "The Noble and Often Nobel Role of Insulin-Related Research"

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