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Gestational Diabetes: Conversations Between the Placenta and Adipose Tissue

Tiffany A. Moore Simas, MD, MPH, MEd, FACOG

Chair, Department of Obstetrics & Gynecology, UMass Medical School

Silvia Corvera, MD

Chair in Diabetes Research, Director, MSTP (MD-PhD) Program, UMass Medical School

The talk was co-presented at UMass Endocrinology Grand Rounds via Zoom on May 25, 2021.  They were introduced by Dr. David Harlan.

At the conclusion of this video, you'll understand:

  • The prevalence and current care standards for gestational diabetes screening, diagnosis and treatment 
  • Anatomic and physiologic adaptions of pregnancy that lead to increased adipose tissue and insulin resistance 
  • Human data and mouse models that informed a novel role for PAPP-A in gestational diabetes

VIDEO

Learn about Drs. Moore Simas and Corvera’s study

"PAPPA-mediated adipose tissue remodeling mitigates insulin resistance and protects against gestational diabetes in mice and humans"

Read about their study published in Science Translational Medicine that outlines a new role for pregnancy-associated plasma protein A, known as PAPPA, in gestational diabetes, with translational potential as both a diagnostic tool and therapeutic target.


Diabetes Research Talks Video Archive

David M. Harlan, MD - "100 Years of Insulin - A Medical Marvel: The Past, Present & Future"
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Michael A. Brehm, PhD - "Exploring Humanized Mouse Models for Diabetes Research and Beyond"
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David M. Harlan, MD - "The Noble and Often Nobel Role of Insulin-Related Research"
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Benjamin U. Nwosu, MD - "Does partial clinical remission impact lipid-based cardiovascular risk in adult patients with T1D?"
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Mark Schuta, MD - “Improving Diabetes Care in the United States: Identifying the Major Problems and Proposed First Steps”
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Tiffany A. Moore Simas, MD, MPH, MEd, FACOG & Silvia Corvera, MD - "Gestational Diabetes: Conversations Between the Placenta and Adipose Tissue"
View video of their 5/25/21 UMass Endocrine Grand Rounds

Mark Reitman, MD, PhD - "Understanding Regulation of Metabolic Rate and Body Temperature to Understand Obesity”
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of his  5/11/21 UMass Endocrine Grand Rounds

Jonathan Krakoff, MD - "Does Energy Expenditure Mediate Weight Gain?"
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Neil B. Marya, MD - “Endoscopic Management of Weight Regain Following Bariatric Surgery”
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John P. Mordes, MD - "Endocrinology and COVID-19"
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Katharine Garvey MD, MPH - “Health Care Transition in Young Adults with Type 1 Diabetes: Challenges and Opportunities”
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David M. Harlan, MD - "Type 1 Diabetes Pathogenesis: Lessons Learned, Lessons Forgotten & Open Questions"
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Jack A. Yanovski, MD, PhD - "Genetics of Obesity”
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Robert H. Eckel, MD - “Cardiometabolic Medicine: Time For A New Internal Medicine Subspecialty”
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Anthony Ferrante, Jr., MD, PhD - "Immune Function in Adipose Tissue Homeostasis”
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Desmond Schatz, MD - “Personalizing Therapies for the Prevention of Type 1 Diabetes: Searching for Endotypes”
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Kevin Hall, PhD “Calories, Carbs, or Quality: What Matters Most for Body Weight?”
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Clifford Rosen, MD - "A New Counter-Regulatory Hormone During Exercise: The Story of Irisin"
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Carl June, MD - Pioneer of CAR T Cell Immunotherapy
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Ezio Bonifacio, PhD - “Auto Antibodies as Predictors of Type 1 Diabetes”
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Anette-Gabriele Ziegler, MD, PhD “Clinical Trials Related to Type 1 Diabetes and its Treatment”
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