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Yong-Xu Wang, PhD

Yong-Xu Wang received his BS in 1989 from Peking University, China, and his PhD in 1999 from the University of Iowa.  

Postdoctoral fellow at the Salk Institute from 1999 to 2004. 

Joined the Program in Gene Function and Expression at University of Massachusetts Medical School as Assistant Professor in 2005. 
Currently Associate Professor, Program in Molecular Medicine.

Brown fat development and browning of white fat

Brown fat and white fat have opposite function-energy expenditure and energy storage, respectively.  White fat displays considerable plasticity of switching to brown-like adipocytes under proper stimuli.  Brown and brown-like adipocytes are present in adult humans and have become a potential drug discovery target for obesity and associated metabolic diseases. 

Our research investigates cellular and molecular mechanisms controlling brown fat fate determination and maintenance.  We're interested in whether these mechanisms can convert white adipocytes into brown-like adipocytes.  We particularly focus on transcriptional control, epigenetics, non-coding RNAs, and signaling molecules.  Our lab utilizes an array of tools such as knockout and transgenic mice, deep sequencing, and CRISPR-mediated genome editing in our study.

Rotation projects and postdoctoral positions are available

Contact information for Wang Lab can be found here.