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Jennifer P. Wang, MD

Professor, Department of Medicine, Division of Infectious Diseases and Immunology,
University of Massachusetts Medical School

Residency, Internal Medicine, Oregon Health and Science University, Portland, OR
Fellowship, Infectious Diseases, University of California, San Diego, La Jolla, CA
M.D., University of Michican, Ann Arbor, MI
A.B., Biochemical Sciences (cum laude), Harvard College, Cambridge, MA

Type 1 Diabetes & Respiratory Viruses Research

Studying how innate immune response mechanisms contribute to autoimmune type 1 diabetes (T1D).

Dr. Wang is an infectious disease and immunology physician-scientist.  Her ongoing research involves the study of human islets as well as rodent models to identify autoimmune and inflammatory pathways which could potentially be blocked to prevent disease development.  

Studying the Effects of Viral Infections on the Development of Type 1 Diabetes Using Stem-Cell Derived Beta Cells

Jennifer Wang Receives Funding Grant to Continue Investigating How Viruses Trigger Type 1 Diabetes

Dr. Wang also studies innate immune responses to respiratory viruses including influenza and SARS-CoV-2, the causative agent of COVID-19.

Her research is supported by awards from the National Institutes of Health, DARPA, and the Department of Defense.

Selected Publications for T1D

Coxsackievirus B Type 4 Infection in beta Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

Bernard H, Teijeiro A, Chaves-Pérez A, Perna C, Satish B, Novials A, Wang JP, Djouder N.Cell Rep Med. 2020 Oct 20;1(7):100125. doi: 10.1016/j.xcrm.2020.100125. eCollection 2020 Oct 20.PMID: 33205075 Free PMC article.

Proteomic and Transcriptional Profiles of Human Stem Cell-Derived β Cells Following Enteroviral Challenge

Nyalwidhe JO, Jurczyk A, Satish B, Redick S, Qaisar N, Trombly MI, Vangala P, Racicot R, Bortell R, Harlan DM, Greiner DL, Brehm MA, Nadler JL, Wang JP.Microorganisms. 2020 Feb 20;8(2):295. doi: 10.3390/microorganisms8020295.PMID: 32093375 

Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice

Redick SD, Leehy L, Rittenhouse AR, Blodgett DM, Derr AG, Kucukural A, Garber MG, Shultz LD, Greiner DL, Wang JP, Harlan DM, Bortell R, Jurczyk A.FASEB J. 2020 Jan;34(1):1901-1911. doi: 10.1096/fj.201901022RR. Epub 2019 Dec 10.PMID: 31914605 

Potential role of type I interferon in the pathogenic process leading to type 1 diabetes

Qaisar N, Jurczyk A, Wang JP.
Curr Opin Endocrinol Diabetes Obes. 2018 Apr;25(2):94-100. doi: 10.1097/MED.0000000000000399. Review.  PMID: 29369915

Coxsackievirus-Induced Proteomic Alterations in Primary Human Islets Provide Insights for the Etiology of Diabetes

Nyalwidhe JO, Gallagher GR, Glenn LM, Morris MA, Vangala P, Jurczyk A, Bortell R, Harlan DM, Wang JP, Nadler JL.J Endocr Soc. 2017 Oct 1;1(10):1272-1286. doi: 10.1210/js.2017-00278. eCollection 2017 Oct 1. PubMed PMID: 29264452; PubMed Central PMCID: PMC5686651

A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats

Qaisar N, Lin S, Ryan G, Yang C, Oikemus SR, Brodsky MH, Bortell R, Mordes JP, Wang JP. Diabetes. 2017 Jan;66(1):145-157. doi: 10.2337/db16-0462. Epub 2016 Oct 7. PMID:27999109

Viral infection of engrafted human islets leads to diabetes

Gallagher GR, Brehm MA, Finberg RW, Barton BA, Shultz LD, Greiner DL, Bortell R, Wang JP. Diabetes. 2015 Apr;64(4):1358-69. doi: 10.2337/db14-1020. Epub 2014 Nov 12. PMID: 25392246

Selected Publications for Respiratory Viruses

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

Kalil AC, Patterson TF, Mehta AK, Tomashek KM, Wolfe CR, Ghazaryan V, Marconi VC, Ruiz-Palacios GM, Hsieh L, Kline S, Tapson V, Iovine NM, Jain MK, Sweeney DA, El Sahly HM, Branche AR, Regalado Pineda J, Lye DC, Sandkovsky U, Luetkemeyer AF, Cohen SH, Finberg RW, Jackson PEH, Taiwo B, Paules CI, Arguinchona H, Erdmann N, Ahuja N, Frank M, Oh MD, Kim ES, Tan SY, Mularski RA, Nielsen H, Ponce PO, Taylor BS, Larson L, Rouphael NG, Saklawi Y, Cantos VD, Ko ER, Engemann JJ, Amin AN, Watanabe M, Billings J, Elie MC, Davey RT, Burgess TH, Ferreira J, Green M, Makowski M, Cardoso A, de Bono S, Bonnett T, Proschan M, Deye GA, Dempsey W, Nayak SU, Dodd LE, Beigel JH; ACTT-2 Study Group Members. N Engl J Med. 2021 Mar 4;384(9):795-807. doi: 10.1056/NEJMoa2031994. Epub 2020 Dec 11.PMID: 33306283 

Unique structural solution from a V(H)3-30 antibody targeting the hemagglutinin stem of influenza A viruses

Harshbarger WD, Deming D, Lockbaum GJ, Attatippaholkun N, Kamkaew M, Hou S, Somasundaran M, Wang JP, Finberg RW, Zhu QK, Schiffer CA, Marasco WA.Nat Commun. 2021 Jan 25;12(1):559. doi: 10.1038/s41467-020-20879-6.PMID: 33495478 

Remdesivir for the Treatment of Covid-19 - Final Report

Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, Hohmann E, Chu HY, Luetkemeyer A, Kline S, Lopez de Castilla D, Finberg RW, Dierberg K, Tapson V, Hsieh L, Patterson TF, Paredes R, Sweeney DA, Short WR, Touloumi G, Lye DC, Ohmagari N, Oh MD, Ruiz-Palacios GM, Benfield T, Fätkenheuer G, Kortepeter MG, Atmar RL, Creech CB, Lundgren J, Babiker AG, Pett S, Neaton JD, Burgess TH, Bonnett T, Green M, Makowski M, Osinusi A, Nayak S, Lane HC; ACTT-1 Study Group Members.N Engl J Med. 2020 Nov 5;383(19):1813-1826. doi: 10.1056/NEJMoa2007764. Epub 2020 Oct 8.PMID: 32445440 

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH 2nd, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi LE, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J; HCA Lung Biological Network. Electronic address: lung-network@humancellatlas.org; HCA Lung Biological Network.Cell. 2020 May 28;181(5):1016-1035.e19. doi: 10.1016/j.cell.2020.04.035. Epub 2020 Apr 27.PMID: 32413319

The role of platelets in mediating a response to human influenza infection

Koupenova M, Corkrey HA, Vitseva O, Manni G, Pang CJ, Clancy L, Yao C, Rade J, Levy D, Wang JP, Finberg RW, Kurt-Jones EA, Freedman JE.Nat Commun. 2019 Apr 16;10(1):1780. doi: 10.1038/s41467-019-09607-x.PMID: 30992428 

Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody

Prachanronarong KL, Canale AS, Liu P, Somasundaran M, Hou S, Poh YP, Han T, Zhu Q, Renzette N, Zeldovich KB, Kowalik TF, Kurt-Yilmaz N, Jensen JD, Bolon DNA, Marasco WA, Finberg RW, Schiffer CA, Wang JP.J Virol. 2019 Jan 4;93(2):e01639-18. doi: 10.1128/JVI.01639-18. Print 2019 Jan 15.PMID: 30381484 

Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness

Canale AS, Venev SV, Whitfield TW, Caffrey DR, Marasco WA, Schiffer CA, Kowalik TF, Jensen JD, Finberg RW, Zeldovich KB, Wang JP, Bolon DNA.J Mol Biol. 2018 Apr 13;430(8):1098-1115. doi: 10.1016/j.jmb.2018.02.009. Epub 2018 Feb 18.PMID: 29466705

Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope

Avnir Y, Prachanronarong KL, Zhang Z, Hou S, Peterson EC, Sui J, Zayed H, Kurella VB, McGuire AT, Stamatatos L, Hilbert BJ, Bohn MF, Kowalik TF, Jensen JD, Finberg RW, Wang JP, Goodall M, Jefferis R, Zhu Q, Kurt Yilmaz N, Schiffer CA, Marasco WA.Cell Rep. 2017 Dec 12;21(11):3243-3255. doi: 10.1016/j.celrep.2017.11.056.PMID: 29241550 

The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution

Ormond L, Liu P, Matuszewski S, Renzette N, Bank C, Zeldovich K, Bolon DN, Kowalik TF, Finberg RW, Jensen JD, Wang JP.Genome Biol Evol. 2017 Jul 1;9(7):1913-1924. doi: 10.1093/gbe/evx138.PMID: 28854600 

Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase

Prachanronarong KL, Özen A, Thayer KM, Yilmaz LS, Zeldovich KB, Bolon DN, Kowalik TF, Jensen JD, Finberg RW, Wang JP, Kurt-Yilmaz N, Schiffer CA.J Chem Theory Comput. 2016 Dec 13;12(12):6098-6108. doi: 10.1021/acs.jctc.6b00703. Epub 2016 Nov 17.PMID: 27951676

An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy

Bank C, Renzette N, Liu P, Matuszewski S, Shim H, Foll M, Bolon DN, Zeldovich KB, Kowalik TF, Finberg RW, Wang JP, Jensen JD.Evolution. 2016 Nov;70(11):2470-2484. doi: 10.1111/evo.13041. Epub 2016 Sep 13.PMID: 27566611

A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug Resistance

Jiang L, Liu P, Bank C, Renzette N, Prachanronarong K, Yilmaz LS, Caffrey DR, Zeldovich KB, Schiffer CA, Kowalik TF, Jensen JD, Finberg RW, Wang JP, Bolon DNA.J Mol Biol. 2016 Feb 13;428(3):538-553. doi: 10.1016/j.jmb.2015.11.027. Epub 2015 Dec 4.PMID: 26656922

Influenza A virus preferentially snatches noncoding RNA caps

Gu W, Gallagher GR, Dai W, Liu P, Li R, Trombly MI, Gammon DB, Mello CC, Wang JP, Finberg RW.RNA. 2015 Dec;21(12):2067-75. doi: 10.1261/rna.054221.115. Epub 2015 Oct 1.PMID: 26428694 Free PMC article.

Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment

Zeldovich KB, Liu P, Renzette N, Foll M, Pham ST, Venev SV, Gallagher GR, Bolon DN, Kurt-Jones EA, Jensen JD, Caffrey DR, Schiffer CA, Kowalik TF, Wang JP, Finberg RW.Mol Biol Evol. 2015 Jun;32(6):1519-32. doi: 10.1093/molbev/msv044. Epub 2015 Feb 23.PMID: 25713211 Free PMC article.

Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses

Hendricks GL, Velazquez L, Pham S, Qaisar N, Delaney JC, Viswanathan K, Albers L, Comolli JC, Shriver Z, Knipe DM, Kurt-Jones EA, Fygenson DK, Trevejo JM, Wang JP, Finberg RW.Antiviral Res. 2015 Apr;116:34-44. doi: 10.1016/j.antiviral.2015.01.008. Epub 2015 Jan 28.PMID: 25637710 

A complete list of published work can be found in My Bibliography