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Jennifer P. Wang, MD

Type 1 Diabetes Research

Studying how innate immune response mechanisms contribute to virus induced autoimmune type 1 diabetes (T1D).

Dr. Wang is an infectious disease and immunology expert.  Her latest research is using use a new type 1 diabetes animal model to identify autoimmune and inflammatory pathways which could potentially be stopped to prevent the disease from developing.  

A 2017 study published online by the Journal of the Endocrine Society, examined the association between Coxsackie virus and development of T1D.  Protein analyses examined responses to the common childhood infection in cultured human islets, which contain insulin producing beta cells.  It revealed specific proteins that changed after the islet cells were exposed to the virus, indicating that Coxsackie infections can accelerate the loss of beta cells. Those proteins could be potential targets for drugs that could prevent or lessen the immune response associated with viral infection and type 1 diabetes.

Studying the Effects of Viral Infections on the Development of Type 1 Diabetes Using Stem-Cell Derived Beta Cells

Jennifer Wang Receives Funding Grant to Continue Investigating How Viruses Trigger Type 1 Diabetes

Selected Publications

Potential role of type I interferon in the pathogenic process leading to type 1 diabetes
Qaisar N, Jurczyk A, Wang JP.
Curr Opin Endocrinol Diabetes Obes. 2018 Apr;25(2):94-100. doi: 10.1097/MED.0000000000000399. Review.  PMID: 29369915

Coxsackievirus-Induced Proteomic Alterations in Primary Human Islets Provide Insights for the Etiology of Diabetes
Nyalwidhe JO, Gallagher GR, Glenn LM, Morris MA, Vangala P, Jurczyk A, Bortell R, Harlan DM, Wang JP, Nadler JL.J
Endocr Soc
2017 Oct 1;1(10):1272-1286doi: 10.1210/js.2017-00278. eCollection 2017 Oct 1. PubMed PMID: 29264452; PubMed Central PMCID: PMC5686651

A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats
Qaisar N, Lin S, Ryan G, Yang C, Oikemus SR, Brodsky MH, Bortell R, Mordes JP, Wang JP.
Diabetes. 2017 Jan;66(1):145-157. doi: 10.2337/db16-0462. Epub 2016 Oct 7. PMID:27999109

Viral infection of engrafted human islets leads to diabetes
Gallagher GR, Brehm MA, Finberg RW, Barton BA, Shultz LD, Greiner DL, Bortell R, Wang JP.
Diabetes. 2015 Apr;64(4):1358-69. doi: 10.2337/db14-1020. Epub 2014 Nov 12. PMID: 25392246

Increased survival in B-cell-deficient mice during experimental cerebral malaria suggests a role for circulating immune complexes
de Oliveira RB, Wang JP, Ram S, Gazzinelli RT, Finberg RW, Golenbock DT.  
MBio. 2014 Mar 18;5(2):e00949-14. doi: 10.1128/mBio.00949-14. PMID: 24643866

A complete list of published work can be found in My Bibliography