Featured Studies


Crohn's and Ulcerative Colitis Clinical Trials Are Recruiting!  (Docket # H-00007584 and H-0008682)

Is your inflammatory bowel disease (Crohn’s disease and ulcerative colitis) poorly controlled?  Individuals with inflammatory bowel disease (IBD) who are poorly controlled on current medications and are seeking alternate treatment options are invited to participate in one of several experimental pharmaceutical company-sponsored research trials. If you are over the age of 18 and have had a diagnosis of ulcerative colitis or Crohn’s disease for at least 3 months and are currently experiencing symptoms, please contact Anne Foley or Monique Rinner at IBDclinicaltrials@umassmed.edu  to see if you qualify.   Compensation for time and travel is provided, and all study costs are covered.

The Depression Relapse Trial (Docket # H-00007086)

Individuals that are currently suffering from depression are invited to participate in a research study to determine the effectiveness and safety of vortioxetine in preventing relapse in depression for those subjects who respond to treatment with vortioxetine. Study participation will last up to 55 weeks and subjects will receive the study drug vortioxetine. Participants must be:  18 to 75 years of age, suffering from recurrent Major Depressive Disorder,  experiencing current symptoms of depression,  not be pregnant or have plans to become pregnant.  Subjects will receive study drug and study-related care at no cost. Compensation provided.  Contact Jessica Penny @ 774 455 4045.

Genetic Studies of Developmental, Metabolic and Nervous System Disorders (Docket # H-10275)

Do you have a diagnosis of bipolar disorder and are you between the ages of 18 and 65? If you answered yes, we invite you to participate in a research study looking at the genetic studies of Bipolar Disorder. Study participation will entail a commitment of one study visit, and one blood draw. Please call for more information:Jessica Penny 774.455.4045.

Observational Study of Improved Major Depressive Disorder (Docket # H-00006379)

This observational study will be gathering information about subjects’ daily activities, sleep quality, their speech and voice characteristics to see if predications can be made to see if one can predict worsening of MDD symptoms in the near future. Participants must have recently tried, and are currently on an antidepressant and their symptoms of depression are improving. Subjects will receive a Wrist Band and Smart Phone (LogPad®) to record their activities and sleep patterns, as well as speech and voice characteristics. Contact Jessica Penny @ 774-455-4045.

Understanding Clinical Trials (Docket # H-00004365)

Individuals currently suffering from Major Depression, Diabetes, Hypertension or Breast Cancer are invited to participate in a research study to try to find better ways of explaining clinical research to potential subjects of research, so that they can better understand and make good decisions about whether they want to participate. Participation involves watching a brief PowerPoint presentation on a laptop and completing a brief survey.  Participants must be over 18 years of age.  Compensation provided.  Please call Karen Albert at 508-856-8725 or Debbie Truong at 508-856-5378.

Alcohol Behavioral Couple Therapy for Service Members and Veterans (Docket # H-00003823)

 Researchers at UMass Medical School are developing an innovative program for Service Members and Veterans with alcohol-related concerns. The Alcohol Behavioral Couple Therapy Military treatment research program is designed to help service members or veterans and their partners learn skills that will help to reduce drinking and improve relationship functioning.  The program will include a thorough assessment, 15 weekly outpatient couple therapy sessions (free of charge), and a follow-up session.  Compensation will be provided for the intake and follow-up sessions. For more information, please contact Rachel Rosen at (855) 901-2228 or abctmilitary@gmail.com.

Nitroprusside Study Docket # H00007610

The goal of this 6-week research study is to assess the effectiveness of Sodium Nitroprusside, an FDA approved drug for management of hypertension, can improve symptoms of schizophrenia. We seek men and women ages 18-60 with a diagnosis of schizophrenia. Participants will be compensated for their time and travel, and all information will be kept private.  For more information about the study, please call 508-856-MIND (6463) or email MIND@umassmed.edu

Exenatide weekly injection as an adjunctive treatment in patients with schizophrenia Docket # H-00004119

Have you been diagnosed with Schizophrenia or Schizoaffective disorder? Are you interested in helping us learn if a drug called Exenatide may improve your memory and thinking?

If so, you may be eligible to participate in a research study at UMass Medical School. Studies suggest that Exenatide (an FDA-approved drug) can reduce inflammation, which may protect the brain and improve memory and thinking in individuals with schizophrenia or schizoaffective disorder. Your participation in the study will last 24 weeks (6 months).

You will be compensated (paid) for your time. For more information about the study, please call us at 508-856-MIND(6463) or email MIND@umassmed.edu.

 Prelapse Study Docket# H00007426

The goal of this study is to compare the standard treatment for psychosis with a treatment version of the medication aripiprazole that is taken only once each month. Study participants at this study location will receive the care your center usually provides. Those who qualify will receive study-related medical exams, and lab tests at no charge. People in this study will be compensated for their time. In order to participate in the study, individuals must be evaluated by a study doctor and meet certain criteria including, but not limited to:

  • male or female aged 18-35
  • have a clinical diagnosis of psychosis and up to 5 years of antipsychotic medication exposure

For more information about the study, please call us at 508-856-MIND(6463) or email MIND@umassmed.edu.

 Schizophrenia and Alcohol Study Docket# H00005852

If you or a loved one suffers from schizophrenia and abuses alcohol, the Breakaway Study may be able to help.

The purpose of the study is to evaluate the safety and effectiveness of an investigational medication in treating schizophrenia in individuals ages 18 to 65 years old who abuse alcohol. Each individual will be evaluated to determine his or her eligibility to participate in the study. Each patient who qualifies will receive investigational medication, study-related medical exams, and laboratory tests at no cost. Compensation for time and travel may also be available.

For more information about the study, please call us at 508-856-MIND(6463) or email MIND@umassmed.edu.

 Treatment for Marijuana Use and Schizophrenia Docket # H- 00001171

People who have schizophrenia often abuse marijuana. We are studying whether FDA approved medication Clozapine can reduce marijuana use. The study lasts about 14 weeks and involves weekly meetings with the research staff, answering questions about substance use and current symptoms. Half the people in the study will get a medicine called “clozapine” and the other half will get a medicine called “risperidone”. People in the study will not know which type of pill they are getting.

We are looking for people who have been told they have schizophrenia, are willing to take medicine for schizophrenia, use marijuana regularly and are ages 18-55.

People in the study will be paid at each meeting for their time. For more information about the study, please call us at 508-856-MIND(6463) or email MIND@umassmed.edu.



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