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Cardiovascular Research

Research in the Division of Cardiovascular Medicine spans basic investigation through clinical trials and studies. Faculty from Cardiovascular Medicine has specific expertise in the following areas:

Basic and Translational Investigation

We have considerable expertise in the vascular biology of the endothelium (Keaney, Freedman, and Rade) and platelets (Freedman and Rade). Metabolism of both the vasculature (Keaney) and other tissue (Cooper, Fitzgibbons) are also topics of study in the Division. We also have ongoing studies of cardiac development (Trivedi), function (Trivedi, Aurigemma), and conduction (Donahue,McManus) and electrophysiological research (Donahue).

Clinical Investigation

Drs. Keaney and Freedman have longstanding and ongoing collaborations with the Framingham Heart Study. Dr. Freedman established the miRNA high-throughput screening platform for Framingham, and Dr. Keaney established the inflammatory biomarker core. Dr. Ockene has experience with small-scale community engagement studies and Dr. Rade has crafted his own collaborative multi-center studies on bypass graft survival (RIGOR).


We also have a separate clinical trials unit with 42 active trials, 8 more in startup phase, and 14 NIH-sponsored trials with a combined $3.7 million in funding. Dr. McManus has invented several iPhone applications for Afib detection that are in clinical trials and he has established his own registry of Afib and Afib ablations on campus. Drs. Gore, Goldberg, and McManus have pursued surveillance registries such as the Global Registry of Acute Coronary Events, the NHLBI Worcester Heart Attack, Heart Failure, and Venous Thromboembolism Studies. Dr. Ockene established the Lawrence Latino Diabetes Trial for the implementation of evidence-based medicine in the community. Other areas of research involve echocardiography/diastolic function (Aurigemma/Tighe).

Specific Investigators and Links to Research Profiles: 

AURIGEMMA          DONAHUE          FISHER          FITZGIBBONS       


Specific Programs include:

  • Prevention and behavior
  • Adherence
  • Epidemiology
  • Thrombosis
  • Interventional technique
  • Atherosclerosis
  • Cardiac arrhythmias
  • Gene therapy
  • Nuclear cardiology


UMMS Cardiovascular T32

The UMMS Cardiovascular T32 training experience will include highly successful scientists, independent research experiences, and novel academic programs. We have a Masters of Science in Clinical Investigation (MSCI) program for clinician-postdoctoral trainees and multiple PhD programs in the Graduate School of Biomedical Sciences for pre-doctoral trainees. Our breadth of mentors, scientific disciplines, and academic programs offers the flexibility to individualize each trainee’s experience while providing a strong methodological foundation.