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Wen Xue, PhD

Research Focus - CRISPR-based Liver Cancer Modeling and Gene Therapy

  • Engineering CRISPR-based mouse models of cancer
  • Identifying a new tumor suppressor gene network in liver cancer
  • Targeting KRAS in lung cancer therapy using small RNA tools
  • Developing and optimizing new CRISPR tools for genome editing
  • Correcting disease genes in vivo using CRISPR genome editing

Representative Publication

Liu P, Liang S-Q, Zheng C, et al. Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice. Nat Commun. 2021;12(1):2121

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In the News

Getting Results…
  • Flotte lab to develop gene therapy models for genetic lung disease
    Research News

    Flotte lab to develop gene therapy models for genetic lung disease

    Researchers from UMass Chan Medical School have received a five-year $13.6 million program project grant from the National Heart, Lung and Blood Institute to develop new gene therapy models for alpha-1 antitrypsin deficiency, a chronic, debilitating genetic lung disease that shortens the lifespan.

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  • Erik Sontheimer co-leading efforts to develop gene editing toolkit by NIH Somatic Cell Genome Editing Consortium
    Research News

    Erik Sontheimer co-leading efforts to develop gene editing toolkit by NIH Somatic Cell Genome Editing Consortium

    Six UMass Medical School scientists are among the members of the National Institutes of Health’s Somatic Cell Genome Editing Consortium to publish a paper in Nature outlining the program’s goals.

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  • MD/PhD-student-led research finds potential new gene target for pediatric liver cancer
    Research News

    MD/PhD-student-led research finds potential new gene target for pediatric liver cancer

    A new study by a team of UMass Medical School researchers, led by Jordan Smith, MD/PhD candidate, has identified a new therapeutic target in hepatoblastoma, a rare, primarily pediatric liver cancer.

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  • Wen Xue receives $250,000 for pediatric cancer research from Hyundai Hope on Wheels
    Research News

    Wen Xue receives $250,000 for pediatric cancer research from Hyundai Hope on Wheels

    UMass Medical School cancer researcher Wen Xue, PhD, accepted a $250,000 grant Friday from the Hyundai Motor America Hope on Wheels campaign to continue his work toward improving care and treatment options for children with cancer.

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  • CRISPR/Cas9 therapeutic for Tyrosinemia type I delivered to mice
    Research News

    CRISPR/Cas9 therapeutic for Tyrosinemia type I delivered to mice

    According to a study published in Nature Biotechnology, a more efficient delivery of a CRISPR/Cas9 therapeutic to adult mice with the metabolic disease Tyrosinemia type I developed by Wen Xue, PhD, may also prove to be safer for use in humans.

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