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Michael R. Green, MD, PhD

Research Focus - Discovery of Therapeutically Targetable Pathways in Cancer

  • Identification of new genes and regulatory pathways that promote or prevent cancer using transcription-based approaches, functional screens (RNAi and CRISPR) and genomics methods
  • Elucidation of cancer drug resistance mechanisms
  • Modulation of gene expression as a therapeutic approach
  • Development of new gene therapy approaches, such as AAV-mediated delivery of secreted tumor suppressor proteins (with Guangping Gao)

Representative Publication

Ma L, Pak ML, Ou J, et al. Prosurvival kinase PIM2 is a therapeutic target for eradication of chronic myeloid leukemia stem cells. Proc Natl Acad Sci USA. 2019;116(21):10482-10487.

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In the News

Getting Results…
  • UMass Cancer Center funds five UMass Chan research projects
    Research News

    UMass Cancer Center funds five UMass Chan research projects

    The UMass Cancer Center Pilot Project Program has awarded seed grants to five UMass Chan Medical School research projects to enable investigators to gather pilot data for external cancer-focused funding.

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  • Michael Green named vice provost for strategic research initiatives
    Research News

    Michael Green named vice provost for strategic research initiatives

    UMass Medical School has created the role of vice provost for strategic research initiatives and named Michael R. Green, MD, PhD, to the post.

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  • Michael Green and Allan Jacobson elected to American Academy of Arts and Sciences
    Research News

    Michael Green and Allan Jacobson elected to American Academy of Arts and Sciences

    Two distinguished scientists from UMass Medical School—Michael Green, MD, PhD, and Allan Jacobson, PhD—have been elected to the American Academy of Arts and Sciences Class of 2018. They join a group of 213 individuals elected this year that includes Barack Obama and  2018 UMMS Commencement speaker Huda Y. Zoghbi, MD.

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  • Synergy among 40 scientists at Li Weibo Institute for Rare Diseases Research accelerates discovery
    Research News

    Synergy among 40 scientists at Li Weibo Institute for Rare Diseases Research accelerates discovery

    Inspired by patients and their families, 40 scientists at the The Li Weibo (李伟波) Institute for Rare Diseases Research are working together to discover cures for dozens of rare disorders, according to a Facebook Live interview with co-directors Michael Green, MD, PhD, and Guangping Gao, PhD.

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  • Michael Green appointed director of UMass Cancer Center
    Research News

    Michael Green appointed director of UMass Cancer Center

    Michael R. Green, MD, PhD, has been appointed director of the UMass Medical School Cancer Center, Terence R. Flotte, MD, executive deputy chancellor, provost and dean of the school of medicine, has announced.

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