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Louis M. Messina, MD

Research Focus - Hematopoietic Stem Cell-Based Cancer Immunotherapy

  • Study of how hypercholesterolemia impairs colorectal cancer immunosurveillance by an oxidant stress-dependent hematopoietic stem cell (HSC)-autonomous mechanism that reduces the number and function of natural killer T (NKT) and gamma delta (γδ) T cells
  • Development of an HSC-Tet1-dependent NKT and γδ T cell-based cancer immunotherapy
  • Exploration of how physical activity lowers breast cancer incidence by reducing HSC-oxidant stress

Representative Publication

Tie G, Yan J, Khair L, et al. Hypercholesterolemia increases colorectal cancer incidence by reducing production of NKT and γδ T cells from hematopoietic stem cells. Cancer Res. 2017;77(9):2351-2362.

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