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Joseph Jerry, PhD

Research Focus - Mechanisms of Breast Cancer Risk and Resistance

  • Examination of estrogen receptor-dependent R-loops and DNA damage induced by low levels of environmental chemicals in personal care products, stimulating DNA double strand breaks without initiating DNA replication
  • Elucidation of interindividual variation in responses to estrogen in rodent mammary and human breast tissues, which are associated with the pathogenic effects of estrogen in a subset of individuals who are susceptible to breast carcinogenesis
  • Examination of mechanisms by which hormones regulate p53 activity and stem cells in mammary epithelium

Representative Publication

Gregory KJ, Roberts AL, Conlon EM, et al. Gene expression signature of atypical breast hyperplasia and regulation by SFRP1. Breast Cancer Res. 2019;21(1):76.

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