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Guodong Zhang, PhD

Research Focus - Prevention of Colonic Inflammation and Colon Cancer

  • Identification of novel therapeutic targets of colonic inflammation and colon cancer, using LC-MS/MS-based metabolomics to systematically profile fatty acid metabolism in colonic inflammation and colon cancer, and then using pharmacological and genetic approaches to validate the roles of the identified metabolic pathways involved
  • Identification of novel environmental risk factors of colonic inflammation and colon cancer by studying how exposure to environmental compounds alters gut microbiota to increase the risk of these diseases

Representative Publication

Wang W, Yang J, Edin ML, et al. Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as novel therapeutic target of colon tumorigenesis. Cancer Res. 2019;79(8):1822-1830.

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