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Shixia Wang

UMassMed Faculty Page

Inventions:

Title: COMPOSITIONS AND METHODS TO TREAT AIDS. UMMS13-47; Patent 9,675,687.

  • The invention provides codon-optimized DNA's and polypeptides useful for inducing an immune response against HIV.  The compositions and methods provided are based on the discovery that specific polyvalent, primary isolate DNA vaccines can effectively induce an immune response against HIV (e.g., HIV-1), e.g., alone or in combination with boosts of recombinant HIV polypeptide compositions. more info.

Title: RECOMBINANT HIV-1 GP120 IMMUNOGEN WIH THREE DIFFERENT V3 LOOPS FROM VIRUSES OF DIFFERENT CLADES. UMMS11-60; Patent 7,847,085 B2

  • This patented technology provides prophylactic DNA constructs that encode a recombinant HIV-1 gp120 envelope peptide, in which either the V1/V2 loop and the V4 loop, or all three variable loops, including V3, are replaced with a V3 sequence each of which is from a different viral isolate. These constructs generate a more broadly reactive neutralizing antibody than conventional gp120 or V3 DNA or polypeptide immunogens. more info.

 

Innovation Topics: BiologicsInfectious DiseaseHIVVaccinesSexually transmitted disease (STD)Prophylactic

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