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Gyongyi Szabo

 

 

 

 

 

UMassMed Faculty Page

Inventions:

Title: Use of miR-122 to Treat Liver Diseases. UMMS16-56; Patent Pending.  

  • This invention builds on the new discovery that grainyhead-like 1 and 2 (GRHL-1 and -2) proteins inhibit tumor suppressor, microRNA-122 (miR-122). Increasing the bioavailability of miR-122 may potentially help to treat liver diseases such as steatosis, inflammation, fibrosis, and liver cancer such as hepatocellular carcinoma. Therapeutic inhibition GRHL-1&2 may restore the positive therapeutic effects of miR-122 in liver. 

 

Innovation TopicsGene TherapyLiver diseaseFibrosisHepatocellular carcinomaTumor suppressorAAV,  Metabolic inflammationSteatosis

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