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Mary Rusckowski

UMassMed Faculty Page

Inventions:

Title: A Method to Quantify Net Axonal Transport in Motor Nerves. UMMS15-65; Patent Pending. 

  • This invention provides methods of diagnosing motor neuron pathologies either before or after treatment by administering to the subject a radiolabeled agent comprising tetanus toxic C fragment and assessing both transport across the neuromuscular junction and retrograde transport. This novel biomarker system can greatly facilitate the study and treatment of diseases such as ALS. 

Title: MOLECULAR PROBE FOR MULTIMODALITY IMAGING AND TRACKING OF STEM CELLS. UMMS12-33; Patent 9,492,571.

  • To better understand the risks associated with stem cell therapies, this invention provides compounds to track transplanted stem cells in vivo overtime using noninvasive imaging techniques.  Specifically, the invention provides novel multi-modality probes constructed by utilizing (a) the high selectivity of long hydrocarbon chains for binding to plasma membranes of cells, (b) a near-infrared (NIR) dye for optical imaging, and (c) a radionuclide for PET or SPECT imaging. 

 

Innovation TopicsDiagnosticsNeurologyNeurodegenerative disordersAmyolateral Sclerosis (ALS)Nerve injury, Research Tools, Alzheimer's diseasesParkinson'sSpinal cord injuryType I DiabetesType II DiabetesStem cell/Stem cellImagingIschemia  

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