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Jack L Leonard

UMassMed Faculty Page


Title: ANTI-TUMOR PROPERTIES OF DICKKOPF 3B. UMMS12-40; Patent 9,856,301.

  • This invention discloses novel therapeutics and methods for treating tumors and cancers via site-specific delivery of the tumor suppressor Dickkopf 3b (DKK3b). This technology is based on the finding that DKK3 expression is a hallmark of many human cancers and expression levels are inversely related to tumor virulence (e.g., in prostate cancer and ovarian cancer). Further, over-expression of DKK3 has been shown to halt proliferation of prostate cancer cells due to its ability to block the translocation of β-catenin to the nucleus. 


Innovation TopicsBiologics, Ovarian cancerProstate cancer