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Rotation Projects

Please contact me (dan.bolon@umassmed.edu) to find out about the details of current rotation projects. Most rotation projects will be focused parts of larger and ongoing efforts that are compatible with short rotations using existing mutational scanning tools and bioinformatic programs, including:

  1. Investigating connections between HIV protease function and viral infectivity.
  2. Analyze drug resistance in SARS-CoV2 Mpro, or the oncogene BCR-ABL1.
  3. Investigate the mechanism of critical regulatory proteins in yeast including Hsp90 and Gsp1.
  4. Use ancestral protein reconstruction combined with mutational scanning to understand the historical evolution of Hsp90.

Please check out our lab culture page for a description of expectations for lab members.