Page Menu

Publications

Pancreatic Islet Embedding for Paraffin Sections.
Kong Y, Ebrahimpour P, Liu Y, Yang C, Alonso LC.
J Vis Exp. 2018 Jun 29;(136). doi: 10.3791/57931.

Adipose Tissue Derived Free Fatty Acids Initiate Myeloid Cell Accumulation in Mouse Liver in States of Lipid Oversupply.
Harmon DB, Wu C, Dedousis N, Sipula IJ, Stafanovic-Racic M, Schoiswohl G, O'Donnell CP, Alonso LC, Kershaw EE, Kelley EE, O'Doherty RM.
Am J Physiol Endocrinol Metab. 2018 Aug 7. doi: 10.1152/ajpendo.00172.2018. [Epub ahead of print]

Pancreatic Islet Embedding for Paraffin Sections.
Kong Y, Ebrahimpour P, Liu Y, Yang C, Alonso LC.
J Vis Exp. 2018 Jun 29;(136). doi: 10.3791/57

CDKN2A/B T2D Genome-Wide Association Study Risk SNPs Impact Locus Gene Expression and Proliferation in Human Islets.
Kong Y, Sharma RB, Ly S, Stamateris RE, Jesdale WM, Alonso LC.
Diabetes. 2018 May;67(5):872-884. doi: 10.2337/db17-1055. Epub 2018 Feb 6.

Partial clinical remission in type 1 diabetes: a comparison of the accuracy of total daily dose of insulin of <0.3 units/kg/day to the gold standard insulin-dose adjusted hemoglobin A1c of ≤9 for the detection of partial clinical remission.
Lundberg RL, Marino KR, Jasrotia A, Maranda LS, Barton BA, Alonso LC, Nwosu BU.
J Pediatr Endocrinol Metab. 2017 Aug 28;30(8):823-830. doi: 10.1515/jpem-2017-0019.

A predictive model for lack of partial clinical remission in new-onset pediatric type 1 diabetes
Marino KR, Lundberg RL, Jasrotia A, Maranda LS, Thompson MJ, Barton BA, Alonso LC, Nwosu BU.PloS one. 2017; 12(5):e0176860.

In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy
Choudhury SR, Fitzpatrick Z, Harris AF, Maitland SA, Ferreira JS, Zhang Y, Ma S, Sharma RB, Gray-Edwards HL, Johnson JA, Johnson AK, Alonso LC, Punzo C, Wagner KR, Maguire CA, Kotin RM, Martin DR, Sena-Esteves M.
Molecular therapy : the journal of the American Society of Gene Therapy. 2016; 24(7):1247-57.

Islet biology, the CDKN2A/B locus and type 2 diabetes risk     
Kong Y, Sharma RB, Nwosu BU, Alonso LC.                                   
Diabetologia. 2016; 59(8):1579-93. NIHMSID: NIHMS788236       

Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia

Roth Flach RJ, Danai LV, DiStefano MT, Kelly M, Menendez LG, Jurczyk A, Sharma RB, Jung DY, Kim JH, Kim JK, Bortell R, Alonso LC, Czech MP.
The Journal of biological chemistry. 2016; 291(31):16221-30.

PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2
Lakshmipathi J, Alvarez-Perez JC, Rosselot C, Casinelli GP, Stamateris RE, Rausell-Palamos F, O'Donnell CP, Vasavada RC, Scott DK, Alonso LC, Garcia-Ocaña A.
Diabetes. 2016; 65(5):1283-96.

Glucose Induces Mouse β-Cell Proliferation via IRS2, MTOR, and Cyclin D2 but Not the Insulin Receptor
Stamateris RE, Sharma RB, Kong Y, Ebrahimpour P, Panday D, Ranganath P, Zou B, Levitt H, Parambil NA, O'Donnell CP, García-Ocaña A, Alonso LC.
Diabetes. 2016; 65(4):981-95.

Early initiation of low-level parenteral dextrose induces an accelerated diabetic phenotype in septic C57BL/6J mice
Singamsetty S, Shah FA, Guo L, Watanabe Y, McDonald S, Sharma R, Zhang Y, Alonso LC, O'Donnell CP, McVerry BJ.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 2016; 41(1):12-9. NIHMSID: NIHMS758866

Insulin demand regulates β cell number via the unfolded protein response
Sharma RB, O'Donnell AC, Stamateris RE, Ha B, McCloskey KM, Reynolds PR, Arvan P, Alonso LC.
The Journal of clinical investigation. 2015; 125(10):3831-46.

Evaluation, Medical Therapy, and Course of Adult Persistent Hyperinsulinemic Hypoglycemia After Roux-en-Y Gastric Bypass Surgery: A Case Series
Mordes JP, Alonso LC
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2015; 21(3):237-46. NIHMSID: NIHMS758862

β-catenin links hepatic metabolic zonation with lipid metabolism and diet-induced obesity in mice
Behari J, Li H, Liu S, Stefanovic-Racic M, Alonso L, O'Donnell CP, Shiva S, Singamsetty S, Watanabe Y, Singh VP, Liu Q.
The American journal of pathology. 2014; 184(12):3284-98.

Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well?
Sharma RB, Alonso LC.
Current diabetes reports. 2014; 14(6):492. NIHMSID: NIHMS586895

Human β-cell regeneration: progress, hurdles, and controversy
Jurczyk A, Bortell R, Alonso LC.
Current opinion in endocrinology, diabetes, and obesity. 2014; 21(2):102-8. NIHMSID: NIHMS586933

Glucagon regulates hepatic kisspeptin to impair insulin secretion
Song WJ, Mondal P, Wolfe A, Alonso LC, Stamateris R, Ong BW, Lim OC, Yang KS, Radovick S, Novaira HJ, Farber EA, Farber CR, Turner SD, Hussain MA.
Cell metabolism. 2014; 19(4):667-81. NIHMSID: NIHMS576298

The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes
Kilic G, Alvarez-Mercado AI, Zarrouki B, Opland D, Liew CW, Alonso LC, Myers MG Jr, Jonas JC, Poitout V, Kulkarni RN, Mauvais-Jarvis F.
PloS one. 2014; 9(2):e87941.

Adaptive β-cell proliferation increases early in high-fat feeding in mice, concurrent with metabolic changes, with induction of islet cyclin D2 expression
Stamateris RE, Sharma RB, Hollern DA, Alonso LC.
American journal of physiology. Endocrinology and metabolism. 2013; 305(1):E149-59.

Time-dependent changes in glucose and insulin regulation during intermittent hypoxia and continuous hypoxia
Lee EJ, Alonso LC, Stefanovski D, Strollo HC, Romano LC, Zou B, Singamsetty S, Yester KA, McGaffin KR, Garcia-Ocana A, O'Donnell CP
European journal of applied physiology. 2013; 113(2):467-78. NIHMSID: NIHMS444538

Exogenous glucose administration impairs glucose tolerance and pancreatic insulin secretion during acute sepsis in non-diabetic mice
Watanabe Y, Singamsetty S, Zou B, Guo L, Stefanovski D, Alonso LC, Garcia-Ocana A, O'Donnell CP, McVerry BJ.
PloS one. 2013; 8(6):e67716.

ChREBP mediates glucose-stimulated pancreatic β-cell proliferation
Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK.
Diabetes. 2012; 61(8):2004-15.

Simultaneous measurement of insulin sensitivity, insulin secretion, and the disposition index in conscious unhandled mice
Alonso LC, Watanabe Y, Stefanovski D, Lee EJ, Singamsetty S, Romano LC, Zou B, Garcia-Ocaña A, Bergman RN, O'Donnell CP
Obesity (Silver Spring, Md.). 2012; 20(7):1403-12. NIHMSID: NIHMS355326

Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus
Demirci C, Ernst S, Alvarez-Perez JC, Rosa T, Valle S, Shridhar V, Casinelli GP, Alonso LC, Vasavada RC, García-Ocana A
Diabetes. 2012; 61(5):1143-52.

Free fatty acids block glucose-induced β-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18
Pascoe J, Hollern D, Stamateris R, Abbasi M, Romano LC, Zou B, O'Donnell CP, Garcia-Ocana A, Alonso LC
Diabetes. 2012; 61(3):632-41.

Activation of protein kinase C-ζ in pancreatic β-cells in vivo improves glucose tolerance and induces β-cell expansion via mTOR activation
Velazquez-Garcia S, Valle S, Rosa TC, Takane KK, Demirci C, Alvarez-Perez JC, Mellado-Gil JM, Ernst S, Scott DK, Vasavada RC, Alonso LC, Garcia-Ocaña A.
Diabetes. 2011; 60(10):2546-59.

Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice
Levitt HE, Cyphert TJ, Pascoe JL, Hollern DA, Abraham N, Lundell RJ, Rosa T, Romano LC, Zou B, O'Donnell CP, Stewart AF, Garcia-Ocaña A, Alonso LC.
Diabetologia. 2011; 54(3):572-82. NIHMSID: NIHMS255203

Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes
Mellado-Gil J, Rosa TC, Demirci C, Gonzalez-Pertusa JA, Velazquez-Garcia S, Ernst S, Valle S, Vasavada RC, Stewart AF, Alonso LC, Garcia-Ocaña A
Diabetes. 2011; 60(2):525-36.

Glucose mediated regulation of beta cell proliferation
Garcia-Ocana A, Alonso LC.
The open endocrinology journal. 2010

Hyperinsulinemia predicts survival in a hyperglycemic mouse model of critical illness
Woodske ME, Yokoe T, Zou B, Romano LC, Rosa TC, Garcia-Ocana A, Alonso LC, O'Donnell CP, McVerry BJ
Critical care medicine. 2009; 37(9):2596-603. NIHMSID: NIHMS661742

Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic beta-cell replication in mice
Yokoe T, Alonso LC, Romano LC, Rosa TC, O'Doherty RM, Garcia-Ocana A, Minoguchi K, O'Donnell CP
The Journal of physiology. 2008; 586(3):899-911.

Glucose infusion in mice: a new model to induce beta-cell replication
Alonso LC, Yokoe T, Zhang P, Scott DK, Kim SK, O'Donnell CP, Garcia-Ocaña A
Diabetes. 2007; 56(7):1792-801. NIHMSID: NIHMS26254

Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity
Iiyori N, Alonso LC, Li J, Sanders MH, Garcia-Ocana A, O'Doherty RM, Polotsky VY, O'Donnell CP
American journal of respiratory and critical care medicine. 2007; 175(8):851-7.

The hair cycle
Alonso L, Fuchs E
Journal of cell science. 2006; 119(Pt 3):391-3.

Islet Cell Growth Factors
Gonzalez-Pertusa J, Alonso L, Garcia-Ocana A.
Kulkarni R, editor. Austin, TX: Landes Bioscience; 2006. Hepatocyte Growth Factor and the pancreatic beta cel

Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle
Alonso L, Okada H, Pasolli HA, Wakeham A, You-Ten AI, Mak TW, Fuchs E.
The Journal of cell biology. 2005; 170(4):559-70. NIHMSID: NIHMS5346

Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA
Kobielak K, Pasolli HA, Alonso L, Polak L, Fuchs E.
The Journal of cell biology. 2003; 163(3):609-23.

Stem cells of the skin epithelium
Alonso L, Fuchs E.
Proceedings of the National Academy of Sciences of the United States of America. 2003; 100 Suppl 1:11830-5.

Stem cells in the skin: waste not, Wnt not
Alonso L, Fuchs E.
Genes & development. 2003; 17(10):1189-200.

Molecular genetic and endocrine mechanisms of hair growth
Alonso LC, Rosenfield RL.
Hormone research. 2003; 60(1):1-13.

Oestrogens and puberty
Alonso LC, Rosenfield RL.
Best practice & research. Clinical endocrinology & metabolism. 2002; 16(1):13-30.

Functional characterization of soluble and membrane-bound forms of vaccinia virus complement control protein (VCP)
Rosengard AM, Alonso LC, Korb LC, Baldwin WM 3rd, Sanfilippo F, Turka LA, Ahearn JM.
Molecular immunology. 1999; 36(10):685-97.

Utility of adenoviral-mediated Fas ligand gene transfer to modulate islet allograft survival
Judge TA, Desai NM, Yang Z, Rostami S, Alonso L, Zhang H, Chen Y, Markman JF, DeMateo RP, Barker CF, Naji A, Turka LA.
Transplantation. 1998; 66(4):426-34.

Additional Resources
click to open search panel