Diseases like rheumatoid arthritis and cancer affect millions every year, and our studies could help alleviate human suffering by identifying new drugs.
Our lab uses kinetic and structural analyses to guide the design of small molecule inhibitors, which we then synthesize and evaluate as inhibitors.
Fuhrmann, J., Clancy, K., Thompson, P.R. (2015) Chemical Biology of Protein Arginine Modifications in Epigenetic Regulation. Rev. 115 , 5413-5461. PMC4463550
Humphries, F., Shmuel-Galia, L., Jiang, Z., Zhou, J., Barasa, L., Mondal, S., Wilson, R, Sultana, N., Shaffer, S.A., Ng, S., Pesiridis, G.S., Thompson, P.R.* and Fitzgerald, K.A. * (2023) Targeting STING oligomerization with small-molecule inhibitors. PNAS 120, e2305420120.
Mondal, S., Chen, Y., Lockbaum, G.J., Sen, S., Chaudhuri, S. Reyes, A.C., Lee, J.M., Kaur, A.N., Sultana, N. Cameron, M.D., Shaffer, S.A., Schiffer, C.A., Fitzgerald, K.A., and Thompson, P.R. (2022) Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2. J. Am Chem Soc. 144, 21305-21045. PMID: 36356199. PMC9662648
Mondal, S., Wang, S., Zheng, Y., Sen, S., Chatterjee, A., and Thompson, P. R. (2021) Site-Specific Incorporation of Citrulline into Proteins in Mammalian Cells. Nature Comm. 12, 45. PMID: 33398026