UMass Wound Research Synopsis

University of Massachusetts Memorial Health Care is the largest not-for-profit health care system in the central Massachusetts region, with 1,500 physicians and over 10,000 employees. 

Our comprehensive network, including the University of Massachusetts Memorial Wound Center, features teaching hospitals, affiliated community hospitals, outpatient clinics, community-based physician practices, long-term care facilities, home health hospice, and rehabilitation and mental health services. UMass Memorial is dedicated to promoting health and wellness in the community, and celebrates its role as the clinical partner of the University of Massachusetts Medical School. 

Conditions treated at the Wound Center are caused by a number of factors that include diabetes, cancer, trauma and non-trauma injuries, vascular disorders and burns. The Wound Center is also the site for post-surgery follow-up care. We have a multi-disciplinary team consisting of plastic surgeons, physician’s assistants, wound care specialists and registered nurses that specialize in vascular surgery, orthopedics, podiatry, nutrition, physical therapy and orthotics.  

The Wound Center treats approximately 4000 patients per year ranging from adolescents to the elderly. The target population are patients seeking treatments for decubitus ulcers, venous ulcers, leg ulcers, bone infections, diabetic ulcers, burn care, scar management, complex surgical wounds and traumatic wounds, as well as slow healing and chronic wounds with or without lymphadema. 

Patients who choose the Wound Centerbenefit from direct access to a leading medical environment staffed by the finest specialists in many surgical and related health care disciplines.  

The Division of Plastic Surgery

Faculty in the Division of Plastic Surgery have been conducting animal and clinical research for more than12 years. We have been involved in drug and device clinical trials focusing on novel dressings for chronic wounds, sternal closure plates following open heart surgery, implantable biomaterial for reconstructive surgery, etc. We also are fully capable of conducting pre-clinical animal studies and basic science research related to wound healing.

 

 

Areas of Research Interest and Expertise

  • Chronic non-healing wounds
  • Burns
  • Skin graft / donor sites
  • Scar Revision
  • Growth Factors
  • Cytokines

Profile of the Organization

 

Team Members of the Division of Plastic Surgery and the UMass Memorial Wound Center: 

¨ Raymond M. Dunn, M.D. – Dr. Dunn has served as the Chief of Plastic Surgery since 1998 and is the director of the UMass Memorial Wound Center. Dr. Dunn graduated from Albany Medical College in 1982 and is board certified with the national Board of Medical Examiners, American Board of Surgery, and the American Board of Plastic Surgery, including added qualifications in hand surgery. Dr. Dunn has been licensed in Massachusetts since 1986 and was named as one of “America’s Top Surgeons” in 2002.  

Dr. Dunn currently serves on nine different committees with UMass and Worcester Polytechnic Institute, where he received a Bachelor of Science degree with honors in 1978. Dr. Dunn’s residency training was at Eastern Virginia Medical School and at UMass Memorial Medical Center. His clinical interests include microsurgery, wound surgery, hand and upper extremity surgery, Plastic Surgery and Cosmetic Surgery. Dr. Dunn is a full Professor at the University of Massachusetts Medical School and an Adjunct Associate Professor in the Department of Biomedical Engineering at Worcester Polytechnic Institute. 

Dr. Dunn holds two patents: #5,449,374: Tissue Spreading Forceps, issued September 12, 1995 and #5,766,432: Method and Device for Eliminating pH Electrode Drift, issuedJune 16, 1998.

¨ Janice F. Lalikos, M.D. – Dr. Lalikos graduated from Johns Hopkins University School of Medicine in 1988 and is board certified with the American Board of Surgery and the American Board of Plastic Surgery. Her general surgery residency training was at Vanderbilt University Hospital. Her plastic surgery residency was completed at UMass Memorial Medical Center, and a craniofacial fellowship at the University of Pittsburgh - Presbyterian Medical Center. Dr. Lalikos’ clinical interests include pediatric plastic surgery, wound care, and tissue engineering. Her curriculum vitae acknowledge 35 peer reviewed publications and 12 grants and 1 patent. Dr. Lalikos is an Associate Professor and Section Chief, Pediatric Plastic Surgery at the UMass Medical School. 

¨ Gary Fudem, M.D. – Dr. Fudem graduated from Case Western Reserve University School of Medicine in 1982 and is board certified with the American Board of Plastic Surgery - Hand Surgery. His residency training was at the UMass Memorial Medical Center-UMass Graduate Medical Education and at Case Western Reserve University Hospitals. Dr. Fudem completed a Hand Surgery fellowship at Hartford Hospital and Microsurgery / Transplantation fellowship at the University of California at Irvine. Dr. Fudem’s clinical interests include wound healing, burn reconstruction, reconstructive surgery, skin cancer biology and treatment, hand surgery and cosmetic surgery. Dr. Fudem is a Professor at UMass Medical School and is Co-Director of the UMass Memorial Burn Unit.

¨ Mustafa Akyurek, M.D. –Dr. Akyurek graduated from Hacettepe University Medical School, Ankara, Turkey, in 1990 and finished a Plastic Surgery residency in the Department of Plastic and Reconstructive Surgery at the same university in 2000. He is a diplomate of American College of Surgeons and certified by the Turkish Board of Plastic Surgery.His clinical interests include breast reconstruction, reconstructive microsurgery, aesthetic breast surgery, and rhinoplasty. His research interests include anatomic studies in perforator flaps, development of new flap designs, especially for breast reconstruction and autologous tissue breast augmentation. Dr. Akyurek is an assistant professor of surgery at UMass Medical School and Director of Microsurgery.

¨ Ronald Ignotz, Ph.D. – Dr. Ignotz is a Research Scientist in the Division of Plastic and Reconstructive Surgery, Adjunct Assistant Professor of Cell Biology. Dr. Ignotz has over 25 years experience conducting research. His main focus has been the biology of growth factors and cytokines with a particular emphasis on TGF-ß and extracellular matrix production. Dr. Ignotz received his Ph.D. degree from the University of Pittsburgh, School of Medicine followed by Postdoctoral training in Biochemistry at the University of Massachusetts Medical School under the supervision of Dr. Joan Massague. Dr. Ignotz is the author of more than two dozen research articles and has presented talks at national and international conferences. 

¨ Heather M. Strom, B.A. – Ms. Strom is the Division’s Research Associate. She graduated Magna Cum Laude from Mount Holyoke College with a Bachelor’s Degree in Biological Sciences in 2000. Her major duties include: retrieving, cataloging and processing samples, data analysis, creating and maintaining experiment schedules, and assisting with manuscript and IRB/IACUC protocol preparation.

 

The University of Massachusetts Medical School Office of Clinical Research

 

The Office of Clinical Research is the contracting entity for industry-sponsored clinical research at the University of Massachusetts Worcester and UMass Memorial Medical Center. For further information, please visit our website at www.umassmed.edu/ocr .

 

Under the supervision of the Office of Research (OOR) is the Clinical Trials Unit (CTU). The CTU is a newly renovated, 2,600-square-foot ambulatory site within UMass. The specialized clinical trials unit is a comfortable and accessible area for study participants. The area includes a waiting area, a conference room for study initiation, monitor visits and education meetings, four staff offices, three workstations for visiting staff, four exam rooms, an infusion room with two recliners, and a private infusion room for those subjects requiring special privileges.

The OOR also provides services such as: 

  • Promoting clinical investigator interests through industry liaisons
  • Assistance with feasibility review of new studies
  • Careful review and assessment of clinical study budgets
  • Thorough and timely review of Clinical Trial Agreements
  • Educational and training opportunities for clinical research staff
  • Investigational pharmacy support and consultation
  • Quality Improvement Initiative

For additional information on Clinical Study/Trial Agreements, please contact Sheila B. Noone, Ph.D. Director, Office of Clinical Research at University of Massachusetts Medical School at (508)856-5015 or e-mail at sheila.noone@umassmed.edu

Investigational Pharmacy Services

The Investigational Pharmacy Service plays a key role in facilitating subject safety for clinical trials being conducted at UMMS and UMMMC. Housed in the clinical system's ambulatory pharmacy, the service is staffed with 2 two full-time investigational pharmacists and a pharmacy technician.

The investigational pharmacy has a critical role in safe clinical trial conduct as it directs receipt, dispensing and storage of investigational drugs. It also has a distinct role as investigator consultant, regulatory expert and compliance professional as it relates to study drugs and their use.

For additional information, please contact: Lucie LaJeunese, RPh, Investigational Drug Pharmacist, at lajeunel@ummhc.org

For additional information on wound research, please contact Dr. Raymond M. Dunn at Raymond.Dunn@umassmemorial.org.