Interventional Neuroradiology - Selected Publications

AK Wakhloo, MJ Gounis, BB Lieber, I Linfante and RM Mericle(eds). Thrombus and Stroke, New York, Informa Healthcare, 2008. (reviewed in AJNR)


Peer Reviewed Journal Articles


1. M Mehra, MC Hurley, MJ Gounis, RM King, A Shaibani, G Dabus, FE Labdag, ER Levy, BR Bendok. The Impact of Coil Shape Design on Angiographic Occlusion, Packing Density and Coil Mass Uniformity in Aneurysm Embolization: An In Vitro Study. J NeuroIntervent Surg 3:131-136, 2011. (received Editor’s Choice and featured on cover).

2. NV Patel, MJ Gounis, AK Wakhloo, NJ Noordhoek, J Blijd, D Babic, D Takhtani, SK Lee, and A Norbash. “Contrast-Enhanced Angiographic Cone-beam CT of Cerebrovascular Stents: Experimental Optimization and Clinical Application.” AJNR Am J Neuroradiol 32(1):137-144, 2011. PMID: 20966059.

3. JY Chueh, AK Wakhloo, GH Hendricks, CF Silva, JP Weaver and MJ Gounis. “Mechanical Characterization of Emboli in Acute Ischemic Stroke and Laboratory Embolus Analogues.” AJNR Am J Neuroradiol 2011 32(7):1237-1244. PMID: 21596804.

4. MJ van der Bom, JPW Pluim, MJ Gounis, EB van de Kraats, J Timmer, R Homan and LW Bartels. “A Method for Facilitating Registration of 2D X-ray Images to 3D MRI.” Phys Med Biol 56:1031-1043, 2011. PMID: 21258138.

5. S Carniato, M Mehra, RM King, AK Wakhloo, and MJ Gounis. “Porcine Brachial Artery Tortuosity For In-Vivo Evaluation Of Neuroendovascular Devices.” AJNR Am J Neuroradiol 2011 (in press)

6. IMJ van der Bom, M Mehra, RP Walvick, JY Chueh, and MJ Gounis. “Quantitative Evaluation of C-arm CT CBV in a Canine Model of Ischemic Stroke.” AJNR Am J Neuroradiol 2011 (accepted)

7. G Spilberg, S Carniato, RM King, IMJ van der Bom, M Mehra, RP Walvick, AK Wakhloo, and MJ Gounis. “Temporal Evolution of Susceptibility Artifact from Coiled Aneurysms on MR Angiography: An In Vivo Canine Study.” AJNR Am J Neuroradiol 2011 (accepted)

8. M Mehra, N Henninger, JA Hirsch, JY Chueh, AK Wakhloo and MJ Gounis. Preclinical Acute Ischemic Stroke Modeling. J NeuroIntervent Surg 2011 (accepted)

9. RG Nogueira, EI Levy, MJ Gounis, AH Siddiqui. “The Trevo device: preclinical data of a novel stroke thrombectomy device in two different animal models of arterial thrombo-occlusive disease.” J NeuroIntervent Surg 2011 (accepted)

10. Grunwald IQ, Wakhloo AK, Walter S, Molyneux AJ, Byrne JV, Nagel S, Kuehn AL, Papadakis M, Fassbender K, Balami JS, Roffi M, Sievert H, Buchan A. Endovascular stroke treatment today. AJNR Am J Neuroradiol 32:238-243, 2011

11. Grunwald IQ, Walter S, Fassbender K, Kuehn AL, Hartmann KM, Wilson N, Sievert H, Kamran M, Hopkins LN, Wakhloo AK. Ischemic strokes in children - New aspects in pediatric stroke treatment. J Pediatrics 2011 (in press)


1. MJ Gounis, MJ De Leo III, AK Wakhloo. “Advances in Interventional Neuroradiology: 2009.” Stroke 41:e81-e87, 2010. PMID: 20075339

2. MJ van der Bom, LW Bartels, MJ Gounis, R Homan, J Timmer, MA Viergever and JPW Pluim. Robust Initialization of 2D-3D Image Registration using the Projection-Slice Theorem and Phase Correlation. Med Phys 37(4):1884-1892, 2010. PMID: 20443510

3. JM Li, PE Newburger, MJ Gounis, X Zhang, P Dargon, LM Messina. Local arterial nanoparticle delivery of siRNA for NOX2 knockdown to prevent restenosis in an atherosclerotic rat model. Gene Ther 17(10):1279-1287 2010. PMID: 20485380

4. 114. Linfante I, Etezadi V, Andreone V, DeLeo M, Aleshashemi S, Shaw K, Wakhloo AK. Intra-arterial abciximab for the treatment of thrombus formation during coil embolization of intracranial aneurysms. J NeuroIntervent Surg 2:135-138, 201


1. MJ Deleo III, MJ Gounis, B Hong, JC Ford, AK Wakhloo and AA Bogdanov Jr. “Carotid Artery Brain Aneurysm Model: In Vivo Molecular Enzyme Specific MR Imaging of Active Inflammation in a Pilot Study” Radiology 252(3):696-703, 2009. PMID: 19546428

2. J Chueh, AK Wakhloo, and MJ Gounis. “Neurovascular modeling: Small batch manufacturing of silicone vascular replicas.” AJNR Am J Neuroradiol 30(6):1159-64, 2009. NIHMSID #105604.

3. B Hong, NV Patel, MJ Gounis, I Linfante, JC Wojak, and AK Wakhloo. “The semi-jailing technique for stent-assisted coiling of complex, wide-necked intracranial aneurysms.” Neurosurgery 65(6):1131-1139, 2009. PMID: 19934972

4. C Sadasivan, L Cesar, J Seong, AK Wakhloo, BB Lieber. Treatment of rabbit elastase-induced aneurysm models by flow diverters: Development of quantifiable indices of device performance using digital subtraction angiography. IEEE Trans Med Imaging 28:1117-1125, 2009

5. Wakhloo AK, DeLeo MJ 3rd, Brown MM. Advances in interventional neuroradiology [Editorial]. Stroke 40:e305-e312, 2009

6. Wakhloo AK. Endovascular treatment of dural carotid cavernous sinus fistulas [Editorial]. J Neuroophthalmol 29:1-2, 2009

7. I. Linfante, MJ DeLeo III, MJ Gounis, and AK Wakhloo. “Cerecyte Versus Platinum Coils in the Treatment of Intracranial Aneurysms: Packing Density, Clinical and Angiographic Mid-Term Results.” AJNR Am J Neuroradiol 30(8):1502-06, 2009. PMID: 19696138

8. Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH; STAIR Group. “Update of the stroke therapy academic industry roundtable preclinical recommendations.” Stroke 40(6):2244-50, 2009. PMID: 19246690

9. C Sadasivan, L Cesar, J Seong, A Rakian, Q Hao, F Tio, AK Wakhloo, BB Lieber. An original flow diversion device for the treatment of intracranial aneurysms. Evaluation in the rabbit elastase-induced model. Stroke 40:952-958, 2009

10. L Cesar, L Miskolczi, BB Lieber, C Sadasivan, MJ Gounis, and AK. Wakhloo. “Neurological deficits associated with the elastase-induced aneurysm model in rabbits.” Neurol Res, May;31(4):414-9, 2009. PMID: 18826754 


11. Linfante I, Andreone V, Akkawi N, Wakhloo AK. Internal carotid artery stenting in patients over 80 years of age: single-center experience and review of the literature. J Neuroimaging. 2009. 19:158-63, PMID: 18800998

12. MJ Gounis, BB Lieber, KA Webster, and AK Wakhloo. “A Novel Angiographic Methodology for the Quantification of Angiogenesis.” IEEE Transactions in Biomedical Engineering 55:996-1003, 2008. PMID: 18334391

13. AK Wakhloo and MJ Gounis. “Retrievable Closed-Cell Intracranial Stent for Foreign Body and Clot Removal.” Neurosurgery 62 (ONS Suppl 2):ONS390–ONS394, 2008. NIHMSID #105606.

14. AK Wakhloo, J Mandell, MJ Gounis, C Brooks, I Linfante, J Winer, and JP Weaver. “Stent-Assisted Reconstructive Endovascular Repair of Cranial Fusiform Atherosclerotic and Dissecting Aneurysms - Long-Term Clinical and Angiographic Follow-Up.” Stroke 39:3288-3296, 2008. PMID: 18772450

15. I Linfante, R Delgado-Mederos, V Andreone, MJ Gounis, LC Hendricks, and AK Wakhloo. Angiographic and Hemodynamic Effect of High Concentration of Intra-Arterial Nicardipine in Cerebral Vasospasm. Neurosurgery 68:1080-1087, 2008. PMID: 19057319

16. Grad Y, Sievert H, Nishri B, Stone GW, Katzen BT, Yodfat O, Higashida R, Harris D, Wakhloo AK, Assaf Y, Norbash A, Bushi D, Lieber BB. A novel endovascular device for emboli rerouting: Part I: Evaluation in a swine model. Stroke 39:2860-2866, 2008 


17. BR Bendok, RJ Parkinson, ZA Hage, JG Adel, and MJ Gounis. “The Effect of Vascular Reconstruction Device-Assisted Coiling on Packing Density, Effective Neck Coverage, and Angiographic Outcome: An In Vitro Study.” Neurosurgery 61:835-840, 2007. PMID: 17986946

18. AK Wakhloo, MJ Gounis, JS Sandhu, N Akkawi, AE Schenck, I Linfante. “Complex-Shaped Platinum Coils for Brain Aneurysms – Higher Packing Density, Improved Biomechanical Stability and Mid-Term Angiographic Outcome.” AJNR Am J Neuroradiol 28: 1395-1400, 2007. PMID: 17698550

19. Linfante I, Wakhloo AK. Brain aneurysms and arteriovenous malformations: advancements and emerging treatments in endovascular embolization. Stroke 8:1411-1417, 2007

20. Seong, J, Wakhloo AK, Lieber BB. In Vitro Evaluation of flow divertors in an elastase-induced saccular aneurysm model in rabbit. J Biomech Eng 129:863-872, 2007

21. Cha KS, Balaras E, Lieber BB, Sadasivan C, Wakhloo AK. Modeling the interaction of coils with the local blood flow after coil embolization of intracranial aneurysms. J Biomech Eng 129:873-879, 2007 

Older (selected from >100)

22. Wakhloo AK, Lieber BB, Cantón G, Levy DI, Lasheras JC, Geindreau C. Changes of Intra-aneurysmal pressure during coiling. AJNR Am J Neuroradiol 27:471- 474, 2006

23. Onizuka M, Miskolczi L, Gounis MJ, Seong J, Lieber BB, Wakhloo AK. Elastase-induced aneurysms in rabbits: effect of post-construction geometry on final size. AJNR Am J Neuroradiol 27:1129-1131, 2006

24. Lieber BB, Sadasivan C, Gounis MJ, Seong J, Miskolczi L, Wakhloo AK. Functional angiography. Critical Reviews in Biomedical Engineering 33:1-102, 2005.

25. Gounis MJ, Spiga MG, Graham RM, Lieber BB, Wakhloo AK, Webster KA. Angiogenesis is confined to the transient period of VEGF expression that follows adenoviral gene delivery to ischemic muscle. Gene Therapy 12:762-771, 2005

26. Wakhloo AK, Lieber BB, Siekman R, Gounis MJ. Hemodynamics in acute and chronic swine rete AVM model. AJNR Am J Neuroradiol 26:1702-1706, 2005

27. Lieber BB, Wakhloo AK, Siekman R, Divani AA, Gounis MJ. Acute and chronic swine rete arteriovenous malformation models: effect of ethiodol and glacial acetic acid on penetration, dispersion, and injection force of n-butyl 2-cyanoacrylate. AJNR Am J Neuroradiol 26:1707-1714, 2005

28. Wakhloo AK, Perlow A, Sandhu J, Linfante I, Cameron J, Troffkin N, Lam BL. Transvenous n-butyl-cyanoacrylate infusion for complex dural carotid cavernous fistulas: Technical considerations and clinical outcome. AJNR Am J Neuroradiol 26:1888-1897, 2005

29. Linfante I, Akkawi NM, Perlow A, Andreone V, Wakhloo AK. Polyglycolide/ polylactide-coated platinum coils for patients with ruptured and unruptured cerebral aneurysms: A Single-Center Experience. Stroke 36:1948 – 1953, 2005

30. Seong J, Sadasivan C, Onizuka M, Gounis MJ, Christian F, Miskolczi L, Wakhloo AK, Lieber BB. Morphology of elastase-induced cerebral aneurysm model in rabbit and rapid prototyping of elastomeric transparent replicas. Biorheology 42:345-361, 2005

31. Seong J, Lieber BB, Wakhloo AK. Morphological age-dependent development of the human carotid bifurcation. J Biomech Eng 38:453-465, 2005

32. Wakhloo AK, Lieber BB, Seong J, Sadasivan C, Gounis MJ, Miskolczi L, Sandhu JS. Hemodynamics of carotid artery atherosclerotic occlusive disease. J Vasc Interv Radiol 15:S111-S121, 2004

33. Troffkin NA, Graham III CB, Berkmen T, Wakhloo AK. Combined Transvenous and Transarterial Embolization of a Tentorial-Incisural Dural Arteriovenous Malformation (DAVM) followed by Primary Stenting of the Associated Stenotic Straight Sinus: Technical Case Report. J Neurosurg 99:579-583, 2003

34. Lieber BB, Livescu V, Hopkins LN, Wakhloo AK. Particle image velocimetry assessment of stent design influence on intraaneurysmal flow. Ann Biomed Eng 30: 768-777, 2002

35. Wakhloo AK, Lieber BB. Device malfunction in endovascular treatment of Intracranial Aneurysms: Shared responsibilities of physician and manufacturer [Editorial]. AJNR Am J Neuroradiol 23: 1265-1267, 2003

36. Berkmen T, Troffkin NA, Wakhloo AK. Direct Percutaneous Puncture of a Cervical Internal Carotid Artery Aneurysm for Coil Placement after Previous Incomplete Stent-Assisted Endovascular Treatment. AJNR Am J Neuroradiol 24: 1230-1233, 2003

37. MJ Gounis, BB Lieber, AK Wakhloo, R Siekmann, and LN Hopkins. “The Effect of Glacial Acetic Acid and Ethiodized Oil Concentration on Embolization Using n-Butyl 2-Cyanoacrylate: An In Vivo Investigation,” Am. J. Neuroradiol. AJNR, 23: 938-44, 2002. PMID: 12063221

38. BB Lieber and MJ Gounis. “The Physics of Endoluminal Stents in the Treatment of Cerebrovascular Aneurysms.” Neurol. Res. Suppl., 24: 33-42, 2002. PMID: 12074435

39. Lanzino G, Mericle RA, Lopes DK, Wakhloo AK, Guterman LR, Hopkins LN. Percutaneous transluminal angioplasty and stent placement for recurrent carotid artery stenosis. J Neurosurg 90:688-694, 1999

40. Schellhammer F, Wakhloo AK, Nagursky H, Schumacher M. Vein graft-coated stents for endovascular occlusion of canine experimental arteriovenous fistulae. Invest Radiol 34:22-27, 1999

41. Lanzino G, Fessler RD, Wakhloo AK, Guterman LR, Hopkins LN. Successful intracranial thrombolysis for cerebral thromboembolic complications resulting from cardiovascular diagnostic and interventional procedures. J Invas Cardiol 11:439-443, 1999

42. Rudin S, Wakhloo AK, Lieber BB, Granger W, Divani A, Bednarek DR, Hopkins LN. Microdroplet tracking using biplane subtraction angiography for cerebral arteriovenous malformation blood flow path and velocity measurements. AJNR Am J Neuroradiol 20:1110-1114, 1999

43. Lanzino G. Wakhloo AK, Fessler RD, Hartney ML, Guterman LR, Hopkins LN. Efficacy and current limitations of intravascular stents for intracranial internal carotid, vertebral, and basilar artery aneurysms. J Neurosurg 91:539-547,1999

44. Mericle RA, Lanzino G, Wakhloo AK, Guterman LR, Hopkins LN. Stenting and secondary coiling of internal carotid artery aneurysm: technical case report. Neurosurgery 43: 1229-1234, 199

45. Wakhloo AK, Lanzino G, Lieber BB, Hopkins LN. Stents for intracranial aneurysms: The beginning of a new endovascular era [Editorial comment]? Neurosurgery 43:377-379, 1998

46. Wakhloo AK, Lieber BB, Rudin S, Duffy-Fronckowiak M, Mericle RA, Hopkins LN. A novel approach to flow quantification in brain arteriovenous malformations prior to enbucrilate embolization: use of insoluble contrast (Ethiodol droplet) angiography. Neurosurg Focus 5(4):3, 1-24, 1998

47. Lanzino G, Wakhloo AK, Fessler RD, Mericle RA, Guterman LR, Hopkins LN. Intravascular stents for intracranial internal carotid and vertebral artery aneurysms: preliminary clinical experience. Neurosurg Focus 5(6):3, 1-10, 1998

48. Fessler RD, Wakhloo AK, Lanzino G, Qureshi AI, Guterman LR, Hopkins LN. Stent placement for vertebral artery occlusive disease: preliminary clinical experience. Neurosurg Focus 5(4):15, 1-10, 1998

49. Szikora I, Wakhloo AK, Guterman LR, Chavis TD, Dawson III RC, Hergenrother RW, Twyford RH, Hopkins LN. Initial experience with collagen-filled Guglielmi detachable coil for endovascular treatment of experimental aneurysms. AJNR Am J Neuroradiol 18:667-672, 1997

50. Aenis M, Stancampiano AP, Wakhloo AK, Lieber BB. Modeling of flow in a straight stented and non-stented side wall aneurysm model. J Biomech Eng 119:206-212, 1997

51. Lieber BB, Stancampiano AP, Wakhloo AK. Alteration of hemodynamics in aneurysm models by stenting: Influence of stent porosity. Ann Biomed Eng 25:460-469, 1997

52. Mericle RA, Wakhloo AK, Rodriguez R, Guterman LR, Hopkins LN. Temporary balloon protection as an adjunct to endosaccular coiling of wide-necked cerebral aneurysms: technical note. Neurosurgery 41:975-978, 1997

53. Wakhloo AK, Tio FO, Lieber BB, Schellhammer F, Graf M, Hopkins LN. Self-expanding nitinol stents in canine vertebral artery: hemodynamics and tissue response. AJNR Am J Neuroradiol 16:1043-1051, 1995

54. Wakhloo AK, Schellhammer F, de Vries J, Haberstroh J, Schumacher M. Self-expanding and balloon-expandable stents in the treatment of carotid aneurysms: an experimental study in a canine model. AJNR Am J Neuroradiol 15:493-502, 1994