T.J. Fitzgerald, M.D

Medical School

1980 M.D. University of Massachusetts Medical School

Residency

1981-1984 Harvard Medical School

Accredidation

1984 American Board of Radiology

Academic Appointment

Professor, Department Chairman

Peer Reviewed Journal Papers

  • C. S. Mayo, L. Ding, A. Addesa, S. Kadish, T.J. Fitzgerald, R. MoserInitial Experience with Volumetric IMRT (RapidArc) for Intracranial Stereotactic Radiosurgery, (Accepted for publication in IJORBP, 10/2009)
  • Marks LB, Cirrincione C, Fitzgerald TJ, Laurie F, Glicksman AS, Vredenburgh J, Prosnitz LR, Shpall EJ, Crump M, Richardson PG, Schuster MW, Ma J, Peterson BL, Norton L, Seagren S, Craig Henderson I, Hurd DD, Peters WP; for the Cancer and Leukemia Group B, Southwest Oncology Group, National Cancer Institute of Canada Clinical Trials Group. Impact of High-Dose Chemotherapy on the Ability to Deliver Subsequent Local-Regional Radiotherapy for Breast Cancer: Analysis of Cancer and Leukemia Group B Protocol 9082. Int J Radiat Oncol Biol Phys. Sep 9. [Epub ahead of print]. 2009
  • Trimble EL, Abrams JS, Meyer RM, Calvo F, Cazap E, Deye J, Eisenhauer E, Fitzgerald TJ, Lacombe D, Parmar M, Seibel N, Shankar L, Swart AM, Therasse P, Vikram B, von Frenckell R, Friedlander M, Fujiwara K, Kaplan RS, Meunier F. Improving Cancer Outcomes Through International Collaboration in Academic Cancer Treatment Trials. J Clin Oncol. Epub ahead of print. PMC Journal- In process. 2009
  • Shankar LK, Van den Abbeele A, Yap J, Benjamin R, Scheutze S, Fitzgerald TJ. Considerations for the use of imaging tools for phase II treatment trials in oncology. Clin Cancer Res. 15(6):1891-7. 2009
  • Laprise NK, Hanusik R, Fitzgerald TJ, Rosen N, White KS. Developing a multi-institutional PACS archive and designing processes to manage the shift from a film to a digital-based archive. J Digit Imaging. 22(1):15-24. 2009
  • Wang T, Alavian MR, Goel HL, Languino LR, Fitzgerald TJ. Bicalutamide inhibits androgen-mediated adhesion of prostate cancer cells exposed to ionizing radiation. Prostate. 68(16):1734-42. 2008
  • Fitzgerald TJ, Wang T, Goel HL, Huang J, Stein G, Lian J, Davis RJ, Doxsey S, Balaji KC, Aronowitz J, Languino LR. Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention. Expert Rev Anticancer Ther. 8(6):967-74. Review. 2008
  • Fitzgerald TJ, Jodoin MB, Tillman G, Aronowitz J, Pieters R, Balducci S, Meyer J, Cicchetti MG, Kadish S, McCauley S, Sawicka J, Urie M, Lo YC, Mayo C, Ulin K, Ding L, Britton M, Huang J, Arous E. Radiation therapy toxicity to the skin. Dermatol Clin.26 (1):161-72, ix. Review. 2008
  • Bogart JA, Watson D, McClay EF, Evans L, Herndon JE, Laurie F, Seagren SL, Fitzgerald TJ, Vokes E, Green MR. Interruptions of once-daily thoracic radiotherapy do not correlate with outcomes in limited stage small cell lung cancer: Analysis of CALGB phase III trial 9235. Lung Cancer. 62(1):92-8. 2008
  • Mayo CS, Urie MM, Fitzgerald TJ, Ding L, Lo YC, Bogdanov M. Hybrid IMRT for Treatment of Cancers of the Lung and Esophagus. Int J Radiat Oncol Biol Phys. 71(5):1408-18. 2008
  • Miralbell R, Fitzgerald TJ, Laurie F, Kessel S, Glicksman A, Friedman HS, Urie M, Kepner JL, Zhou T, Chen Z, Barnes P, Kun L, Tarbell NJ.. Radiotherapy in Pediatric Medulloblastoma: Quality Assessment of Pediatric Oncology Group Trial 9031, Int J Rad Oncol Biol Phys. 64(5):1325-30. 2006
  • Fitzgerald TJ, Aronowitz J, Giulia Cicchetti M, Fisher G, Kadish S, Lo YC, Mayo C, McCauley S, Meyer J, Pieters R, Sherman A. The effect of radiation therapy on normal tissue function. Hematol Oncol Clin North Am. 20(1):141-63. 2006
  • Simon EL, Goel HL, Teider N, Wang T, Languino LR, Fitzgerald TJ. High dose fractionated ionizing radiation inhibits prostate cancer cell adhesion and beta (1) integrin expression. Prostate. 15; 64 (1): 83-91. 2005
  • Mayo CS, Urie M, Fitzgerald TJ. Hybrid IMRT Plans-Concurrently Treating Conventional and IMRT Beams – for Improved Breast Irradiation and Reduced Planning Time, Int J Rad Oncol Bio Phys, 61 (3):922-32. 2005
  • Reznik J, Cicchetti MG, Degaspe B, Fitzgerald TJ. Analysis of axillary coverage during tangential radiation therapy to the breast, Int J Radiat Oncol Biol Phys, 1;61(1):163-8. 2005
  • Sartor CI, Peterson BL, Woolf S, Fitzgerald TJ, Laurie F, Turrisi AJ, Bogart J, Henderson IC, Norton L. Effect of addition of adjuvant Paclitaxel on radiotherapy delivery and locoregional control of node-positive breast cancer: cancer and leukemia group B 9344, J Clin Oncol, 1;23(1):30-40. 2005
  • Fitzgerald TJ, Simon E, Meyer J. Prostate carcinoma: opportunities for translational research, J Cell Biochem, 91(3):433-42, Review. 2004
  • Mayo C, Lo YC, Fitzgerald TJ, Urie M. Forward-planned, multiple-segment, tangential fields with concomitant boost in the treatment of breast cancer, Med Dosim. 29(4):265-70. 2004
  • Wharam MD, Meza J, Anderson J, Breneman JC, Donaldson SS, Fitzgerald TJ, Michalski J, Teot LA, Wiener ES, Meyer WH. Failure pattern and factors predictive of local failure in rhabdomyosarcoma: a report of group III patients on the third Intergroup Rhabdomyosarcoma Study, J Clin Oncol, 15:22(10):1902-8. 2004
  • Urie M, Fitzgerald TJ, Followill D, Laurie F, Marcus R, and Michalski J. Current calibration, treatment, and treatment planning techniques among institutions participating in the Children’s Oncology Group, Int. J. Rad. Oncol. Bio. Phys, 55(1):245-60. 2003
  • Ballen, KK, Becker PS, Emmons RV, Fitzgerald TJ, Hsieh CC, Liu Q, Heyes C, Clark Y, Levy W, Lambert JF, Chiafari F, Szymanski M, Rososhansky S, Popovsky, MA, Stewart, FM, Quesenberry PJ. Low-dose total body irradiation followed by allogeneic lymphocyte infusion may induce remission in patients with refractory hematologic malignancy. Blood; 100(2):442-50. 2002
  • Raney RB, Meza J, Anderson JR, Fryer CJ, Donaldson SS, Breneman JC, Fitzgerald TJ, Gehan EA, Michalski JM, Ortega JA, Qualman SJ, Sandler E, Wharam MD, Wiener ES, Maurer HM, Crist WM. Treatment of children and adolescents with localized paramenigeal sarcoma: experience of the intergroup rhabdomyosarcoma study group protocols IRS-II through IV 1978 – 1997. Med Pediatr Oncol. 38(1):22-32. 2002
  • Halperin EC, Laurie F, Fitzgerald TJ. An evaluation of the relationship between the quality of prophylactic cranial radiotherapy in childhood acute leukemia and institutional experience: a Quality Assurance Review Center – Pediatric Oncology Group Study. Int J Rad Oncol Bio Phys. 53(4):1001-4. 2002
  • Urie M, Lo YC, Litofsky S, Fitzgerald TJ. Miniature multileaf collimator (MMLC) as an alternative to traditional circular collimators for stereotactic radiosurgery and stereotactic radiotherapy. Stereotact Funct Neurosurg 76:47-62. 2001
  • Lo YC, Yasuda G, Fitzgerald TJ, Urie M. Intensity modulation for breast treatment using static multi-leaf collimators, Int J Rad Onc Bio Phys 46:187-94. 2000
  • Rose PG, Tak WK, Fitzgerald TJ, Reale FR, Hunter RE, Nelson BE. Brachytherapy for early endometrial carcinoma: a comparative study with long-term follow-up. Int J Gynecol Cancer. 9:105-9. 1999
  • Wang T, Fitzgerald TJ, Haregewoin A. Differential expression of nitric oxide synthases in EGF-responsive mouse neural precursor cells. Cell Tissue Res. 296:489-97. 1999
  • Colevas AD, Busse PM, Norris CM, Fried M, Tishler RB, Poulin M, Fabian RL, Fitzgerald TJ, Dreyfuss A, Peters ES, Adak S, Costello R, Barton JJ, Posner MR. Induction chemotherapy with docetaxel, cisplatin, fluorouracil, and leucovorin for squamous cell carcinoma of the head and neck: a phase I/II trial. J Clin Oncol. 16(:1331-9. 1998
  • Doyle JW, Li YQ, Salloum A, Fitzgerald TJ, Walton RL. The effects of radiation on neovascularization in a rat model. Plast Reconstr Surg. 98:129-35; discussion 136-9. 1996
  • Sakakeeny MA, Harrington M, Leif J, Merrill W, Pratt D, Romanik E, McKenna M, Fitzgerald TJ, Greenberger JS. Effects of gamma-irradiation on the M-CSF-promoter linked to a chloramphenicol aminoacyl transferase reporter gene expressed in a clonal murine bone marrow stromal cell line. Stem Cells. 12:87-94. 1994
  • Rose PG, Baker S, Kern M, Fitzgerald TJ, Tak WK, Reale FR, Nelson BE, Hunter RE. Primary radiation therapy for endometrial carcinoma: a case controlled study. Int J Radiat Oncol Biol Phys. 27:585-90. 1993
  • Das IJ, Cheng CW, Fosmire H, Kase KR, Fitzgerald TJ. Tolerances in setup and dosimetric errors in the radiation treatment of breast cancer. Int J Radiat Oncol Biol Phys. 26:883-90. 1993
  • Santucci MA, Anklesaria P, Laneuville P, Das IJ, Sakakeeny MA, Fitzgerald TJ, Greenberger JS. Expression of p210 bcr/abl increases hematopoietic progenitor cell radiosensitivity. Int J Radiat Oncol Biol Phys. 26:831-6. 1993
  • Santucci MA, Anklesaria P, Anderson SM, Das IJ, Fitzgerald TJ, Valinsky H, Kase KR, Sakakeeny MA, Greenberger JS. The v-src oncogene may not be responsible for the increased radioresistance of hematopoietic progenitor cells expressing v-src. Radiat Res. 129:297-303. 1992
  • Greenberger J, Leif J, Crawford D, Anklesaria P, English D, Sakakeeny M, Rubin J, Pierce J, Shadduck R, Fitzgerald TJ. Humoral and cell surface interactions during gamma-irradiation leukemogenesis in vitro. Exp Hematol. 20:92-102. 1992
  • Das IJ, Kase KR, Copeland JF, Fitzgerald TJ. Electron beam modifications for the treatment of superficial malignancies. Int J Radiat Oncol Biol Phys. 21:1627-34. 1991
  • Hunter RE, Griffin TW, Stevens S, Roman LD, Bokhari F, Reale FR, Tak WK, Fitzgerald TJ, Dillon MB, Rose PG. High-dose, short-duration cisplatin/doxorubicin combination chemotherapy for advanced ovarian epithelial cancer. Cancer. 68:1890-4. 1991
  • Fitzgerald TJ, Santucci MA, Das I, Kase K, Pierce JH, Greenberger JS. The v-abl, c-fms, or v-myc oncogene induces gamma radiation resistance of hematopoietic progenitor cell line 32d cl 3 at clinical low dose rate. Int J Radiat Oncol Biol Phys. 21:1203-10. 1991
  • Anklesaria P, Greenberger JS, Fitzgerald TJ, Sullenbarger B, Wicha M, Campbell A. Hemonectin mediates adhesion of engrafted murine progenitors to a clonal bone marrow stromal cell line from Sl/Sld mice. Blood. 77:1691-8. 1991
  • Das IJ, Kase KR, Fitzgerald TJ, Ligon DA. Study of dose perturbation parameters for eye shielding in megavoltage photon beam therapy. Int J Radiat Oncol Biol Phys. 19:461-7. 1990
  • Greenberger JS, Wright E, Henault S, Anklesaria P, Leif J, Sakakeeny MA, Fitzgerald TJ, Pierce JH, Kase K. Hematopoietic stem cell- and marrow stromal cell-specific requirements for gamma irradiation leukemogenesis in vitro. Exp Hematol. 18:408-15. 1990
  • Santucci MA, Fitzgerald TJ, Harigaya K, Woda B, Sakakeeny MA, Anklesaria P, Kase K, Holland CA, Greenberger JS. Gamma-irradiation response of cocultivated bone marrow stromal cell lines of differing intrinsic radiosensitivity. Int J Radiat Oncol Biol Phys. 18:1083-92. 1990
  • Matory WE Jr, Wertheimer M, Fitzgerald TJ, Walton RL, Love S, Matory WE. Aesthetic results following partial mastectomy and radiation therapy. Plast Reconstr Surg. 85:739-46. 1990
  • Recht L, Fram RJ, Strauss G, Fitzgerald TJ, Liepman M, Lew R, Kadish S, Sherman D, Wilson J, Greenberger J, et al. Preirradiation chemotherapy of supratentorial malignant primary brain tumors with intracarotid cis-platinum (CDDP) and i.v. BCNU. A phase II trial. Am J Clin Oncol. 13:125-31. 1990
  • Fitzgerald TJ, Henault S, Sakakeeny M, Santucci MA, Pierce JH, Anklesaria P, Kase K, Das I, Greenberger JS. Expression of transfected recombinant oncogenes increases radiation resistance of clonal hematopoietic and fibroblast cell lines selectively at clinical low dose rate. Radiat Res. 122:44-52. 1990
  • Fitzgerald TJ, Henault S, Sakakeeny MA, Santucci MA, Pierce JH, Anklesaria P, Kase K, Lovington K, Greenberger, JS. Resistance of hematopoietic stem cells to x-irradiation at clinical low-dose rate is induced by several classes of oncogenes. Rad Res 122:44-52. 1990
  • Anklesaria P, Fitzgerald TJ, Kase K, Ohara A, Greenberger JS. Improved hematopoiesis in anemic Sl/Sld mice by splenectomy and therapeutic transplantation of a hematopoietic microenvironment. Blood. 74:1144-51. 1989
  • Greenberger JS, Fitzgerald TJ, Anklesaria P. Recent Studies of the hematopoietic microenvironment in long-term bone marrow cultures. Immunol Res. 8(3):226-35. 1989
  • Fitzgerald TJ, Henault S, Santucci MA, Anklesaria P, Zak S, Kase K, Farber N, Pierce JH, Ohara A, Greenberger JS. Recombinant murine GM-CSF increases resistance of some factor dependent hematopoietic progenitor cells to low-dose-rate gamma radiation. Int J Radiat Oncol Biol Phys 17(2):323-35. 1989
  • Fitzgerald TJ, Henault S, Santucci MA, Anklesaria P, Zak S, Kase K, Farber N, Greenberger JS. Increase in low-dose rate x-irradiation resistance of factor dependent hematopoietic progenitor cells by recombinant murine GM-CSF. Int J Rad Oncol Biol Phys 17:323-35. 1989
  • Ohta M, Anklesaria P, Fitzgerald TJ, Kase K, Leif J, Delamarter J, Farber N, Wright E, Greenberger JS. Long-term bone marrow cultures: recent studies with clonal hematopoietic and stromal cell lines. Pathol Immunopathol Res 8(1):1-20. 1989
  • Ohta M, Fitzgerald TJ, Anklesaria P, Wheaton M, Ohara A, Pierce JH, Holland CA, Greenberger JS. Retroviral src gene expression in continuous marrow culture increases the self-renewal capacity of multilineage hematopoietic stem cells. Leukemia 3:206-26. 1989
  • Wollin M, Fitzgerald TJ, Santucci MA, Menon M, Longcope C, Reale F, Carlson J, Sakakeeny MA, Greenberger JS. Radiosensitivity of human prostate cancer and malignant melanoma cell lines. Radiother Oncol. 1989 15:285-93. 1989
  • Fitzgerald TJ, Greenberger JS. Adjuvant Radiotherapy and Its Role in the Treatment of Stage II Lung Cancer. Non-serial; Lung Cancer: A Comprehensive Treatise. Bitran JD, et al, Eds. Orlando, FL Grune and Stratton, pp. 165-71. 1988
  • Fitzgerald TJ, Anklesaria P, Le D, Sakakeeny MA, Kase K, Greenberger JS. Radiosensitivity of cloned permanent murine bone marrow stromal cell lines: Non-uniform effect of low dose rate. Exp Hematol 16:820-7. 1988
  • Fitzgerald TJ, Santucci MA, Harigaya K, Woda B, McKenna M, Sakakeeny MA, Pierce JH, Kase K, Holland, CA, Greenberger JS. Radiosensitivity of permanent human bone marrow stromal cell lines: Effect of dose rate. Int J Rad Oncol Biol & Phys 15:1153-9. 1988
  • Greenberger JS, Fitzgerald TJ, Klassen V, Anklesaria P, Bushnell D, Kase K, Sakakeeny MA. Alteration in hematopoietic stem cell seeding and proliferation by low dose rate irradiation of bone marrow stromal cells in vitro. Int J Rad Oncol Biol Phys 14:85-94. 1988
  • Anklesaria P, Sakakeeny MA, Klassen V, Rothstein L, Fitzgerald TJ, Appel M, Greenberger JS, Holland CA. Expression of a selectable gene transferred by a retroviral vector to hematopoietic stem cells and stromal cells in murine continuous bone marrow cultures. Exp Hematol 15(2):195-202. 1987
  • Anklesaria P, Kase KR, Glowacki J, Holland CH, Sakakeeny MA, Wright JH, Fitzgerald TJ, Lee C-YL, Greenberger JS. Engraftment of clonal bone marrow stromal cell line in vitro stimulates hematopoietic recovery from total body irradiation. Proc Nat Acad Sci 84:7681-85. 1987
  • Anklesaria P, Klassen V, Sakakeeny MA, Fitzgerald TJ, Harrison D, Rybak ME, Greenberger JS. Biological characterization of cloned permanent stromal cell lines from anemic Sl/Sld mice and +/+ littermates. Exp Hematol. 15:636-44. 1987
  • Naparstek E, Anklesaria P, Fitzgerald TJ, Sakakeeny MA, Greenberger JS. Interaction between x-irradiated plateau-phase marrow stromal cell lines and co-cultivated factor-dependent cell lines leading to leukemogenesis in vitro. Scanning Microsc 1(1):247-53. 1987
  • Greenberger JS, Daugherty C, Sakakeeny MA, Braun J, Pierce JH, Eckner, RJ, Fitzgerald TJ. Friend virus-infected long-term bone marrow cultures produce both colony stimulating factor dependent and independent granulocyte-macrophage progenitor cells for over four years in vitro. Leukemia Res 11(1):51-61. 1987
  • Naparstek E, Fitzgerald TJ, Sakakeeny MA, Klassen V, Pierce JH, Woda BA, Falco J, FitzGerald S, Nizin P, Greenberger JS. Induction of malignant transformation of co-cultivated hematopoietic stem cells by X-irradiation of murine bone marrow stromal cells in vitro. Cancer Res 46(9):4677-84. 1986
  • Fitzgerald TJ, McKenna M, Rothstein L, Daugherty C, Kase K, Greenberger JS. Radiosensitivity of human bone marrow granulocyte-macrophage progenitor cells and stromal colony-forming cells: effect of dose rate. Radiat Res. 107(2):205-15. 1986
  • Naparstek E, Pierce JH, Metcalf D, Shadduck R, Ihle JN, Leder A, Sakakeeny MA, Wagner K, Falco J, Fitzgerald TJ, Greenberger, JS. Induction of growth alternations in factor-dependent hematopoietic progenitor cell lines by co-cultivation with irradiated bone marrow stromal cell lines. Blood 67(5):1395-1403. 1986
  • Wang AM, Fitzgerald TJ, Lichtman AH, Power TC, Zamani AA, Haykal HA, Rumbaugh CL. Neuroradiologic features of primary falx osteosarcoma. AJNR Am J Neuroradiol. 7:729-32. 1986
  • Greenberger JS, Fitzgerald TJ, Rothstein L, Pierce J, Sakakeeny MA, Weichselbaum RR, Naparstek E, Newburger P, Griffin J, Bast R Jr. Long-term culture of human granulocytes and granulocyte progenitor cells Prog Clin Biol Res 211:159-85. 1986
  • Greenberger JS, Pechenik J, Lord A, Gould L, Naparstek E, Kase K, Fitzgerald TJ. X-irradiation effects on growth and metamorphosis of gastropod larvae (Crepidula fornicata): a model for environmental radiation teratogenesis. Arch Environ Contam Toxicol. 15:227-34. 1986
  • Fitzgerald TJ, McKenna M, Kase K, Daugherty C, Rothstein L, Greenberger JS. Effect of x-irradiation dose rate on the clonagenic survival of human and experimental animal hematopoietic tumor cell lines: Evidence for heterogeneity. Int J Rad Onc Biol Phys 12(1):69-73. 1986
  • Posner MR, Weichselbaum RR, Fitzgerald TJ, Clark JR, Rose C, Fabian RL, Norris CM Jr, Miller D, Tuttle SA, Ervin TJ. Treatment complications after sequential combination chemotherapy and radiotherapy with or without surgery in previously untreated squamous cell carcinoma of the head and neck. Int J Rad Onc Biol Phys; 11(11):1887-93. 1985
  • Rich TA, Weiss DR, Mies C, Fitzgerald TJ, Chaffey JT. Sphincter preservation in patients with low rectal cancer treated with radiation therapy with or without local excision or fulguration. Radiology. 156(2):527-31. 1985
  • Fitzgerald TJ, Daugherty C, Kase K, Rothstein LA, McKenna M, Greenberger JS. Activated human N-ras oncogene enhances x-irradiation repair of mammalian cells in vitro less effectively at low dose rate. Implications for increased therapeutic ratio of low dose rate irradiation. Am J Clin Oncol. 8:517-22. 1985

Books, Chapters and Monographs

  • Fitzgerald TJ et al. Quality Assurance Programmes in head and neck radio-oncology. In Head and Neck Cancer: Multimodality Management. Ed: Jacques Bernier. 2009
  • Weichselbaum RR, Clark JR, Miller D, Posner MR, Chaffey JT, Fabian RL, Norris CM Jr, Fitzgerald TJ, Rose CM, Ervin TJ. Combination treatment of Head and Neck Cancer with Induction Chemotherapy. Non-serial; Head and Neck Cancer. Volume 1 Chretien PB, Johns ME, Shedd DP, Strong EW, Ward PH, Eds. Philadelphia, B.C. Decker, Inc. 443-49. 1985
  • Fitzgerald TJ, White K, Saltz J, Sharma A, Siegel E, Urie M, Ulin K, Purdy J, Bosch W, Matthews J, Deasy J, Ibbott G, Laurie F, Hanusik R, Yorty J, Bishop-Jodoin M, Kessel S, Cicchetti MG, McCarten K, Rosen N, Pieters R, Voss S, Reaman G, Schnall M, Schilsky R, Knopp M, Schwartz L, Baker L, Comis R, Kun L, Boyett J, Ramamurthy U, Parliament M, Nelson H, Ota D. Development of a Queriable Database for Oncology Outcome Analysis. In: Rubin P, Constine LS, Marks LB, Okunieff P, eds. Cured II - LENT Cancer Survivorship Research And Education. Late Effects on Normal Tissues. New York, NY: Springer;p 61-72 2008