Research and scholarly activity in the Division includes both clinical and basic research and editorship and authorship of two popular Critical Care textbooks (Irwin & Rippe’s Intensive Care Medicine and the Manual of Intensive Care Medicine). Moreover, Dr. Richard S. Irwin is the current Editor-in-Chief of CHEST, the major clinical journal for the fields of pulmonary, critical care and sleep medicine.
Hardy Kornfeld, MD leads an NIH funded laboratory studying host defense against respiratory pathogens with an emphasis on tuberculosis. Basic research projects focus on the mechanisms of TB susceptibility caused by diabetes and related metabolic disorders, host-directed therapies for TB, and the mechanisms and consequences of M. tuberculosis-induced macrophage cell death. Clinical projects include a cohort study (Effects of Diabetes on Tuberculosis Severity) in collaboration with Dr. Vijay Viswanathan in Chennai, India, and a study of lung injury in TB/IRIS in collaboration with Drs. Gregory Bisson (University of Pennsylvania) and Gavin Churchyard (Aurum Institute).
The laboratory of Jinhee Lee, DVM, PhD also has been supported by the NIH and has focused on vaccine development. An effective vaccine against tuberculosis bacteria requires adjuvant actions that enable generation of durable memory CD4 T cells in sufficient numbers. With the aim of ultimately enhancing vaccine efficacy, his research efforts identify and define the immune mechanisms that negatively regulate optimal adjuvanticity.
Craig Lilly, MD has focused on process of care and clinical outcomes studies with a focus on adult critically ill populations, including the linking of large datasets and biological samples. Published studies have focused on the use of health information technology including telemedicine tools, adherence to guidelines, and quality and safety metrics.
J. Mark Madison, MD has interests in both basic and clinical research on asthma. Currently, he is a co-investigator on an NIH funded study examining the effects that mindfulness training has on symptom control and quality of life in patients with asthma.
Richard S. Irwin, MD has multiple research interests in the study of chronic cough, including pathogenesis, diagnosis, treatment and health-related quality of life. He also has interests in resource utilization in caring for the critically ill and in models of caring for the critically ill.
Kimberly Fisher, MD, MS has interests and expertise in analyzing large databases to better understand clinical outcomes. She is also interested in better understanding and improving physician-patient communication in the ICU, especially communication surrounding perceived breakdowns in medical care.
Cynthia French, RN, NP, PhD has research interests better understanding the psychological impact that chronic cough has on patients’ lives. In addition, her work aims to examine and improve the fidelity with which providers follow evidence-based guidelines.