Selected Publications of Molecular Medicine Graduate Students:

Bei, Y., Hogan, H., Berkowitz, L.A., Soto, M., Rocheleau, C.E., Pang, K-M., Collins, J. and Mello, C.C. (2002) SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos.  Developmental Cell (in press).

Tabara, H., Yigit, E., Siomi, H., and Mello, C.C. (2002)  The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-Box helicase to direct RNAi in C. elegans.  Cell 109, 1-20.

Park JG, Bose A, Leszyk J, Czech MP (2001).  PYK2 as a mediator of endothelin-1/Galpha11 signaling to GLUT4 glucose transporters.  J. Biol. Chem. Dec. 21:276(51), 47751-47754.

Klarlund JK, Holik J, Chawla A, Park JG, Buxton J, Czech MP.  (2001).  Signaling complexes of the ferm domain-containing protein grsp1 bound to arf exchange factor grp1.  J. Biol. Chem. Oct. 26:276(43):40065-70.

Bose A, Cherniack AD, Langille SE, Nicoloro SM, Buxton JM, Park JG, Chawla A, Czech MP.  (2001).  G(alpha)11 signaling through ARF6 regulates F-actin mobilization and GLUT4 glucose transporter translocation to the plasma membrane.  Mol Cell Biol. Aug.21(15):5262-75.

Grishok, A., Pasquinelli, A.E., Conte, D., Li, N., Parrish, S., Baillie, D.L., Fire, A., Ruvkun, G., and Mello, C.C. (2001)  Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control developmental timing in Caenorhabditis elegans.  Cell 106, 23-34.

Merithew E, Hatherly S, Dumas JJ, Lawe DC, Heller-Harrison R, Lambright DG.  (2001)   Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition.  J Biol Chem. Apr 27;276(17): 13982-8.

Lawe DC, Chawla A, Merithew E, Dumas J, Carrington W, Fogarty K, Lifshitz L, Tuft R, Lambright D, Corvera S (2001).   Sequential roles for phosphatidylinositol 3-phosphate and Rab5 in tethering and fusion of early endosomes via their interaction with EEA1. J Biol Chem. Oct 15 [epub ahead of print]

Dumas JJ, Merithew E, Sudharshan E, Rajamani D, Hayes S, Lawe D, Corvera S, Lambright D (2001).  Multivalent endosome targeting by homodimeric EEA1.  Mol Cell. Nov;8(5): 947-958.

O'Neil J., Billa M., Oikemus S. and Kelliher M. (2001).  The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice.  Oncogene, 20:  3897-3905.

Zhang L, Sun L, and Cui Z, Gotllieb RL, and Zhang B. (2001) 5'-Sulfhydryl-modified RNA: initiators synthesis, in vitro transcription and enzymatic conjugation, Bioconjugate Chem., 12(6), 939-948.

Zhang B, Cui Z & Sun L, (2001) Synthesis of 5'-deoxy-5'-thioguanosine-5'-mono-phophorothioate and its incorporation into RNA 5'-termini. Org. Lett, 3(2), 275-278.

Keys RA &  Green MR (2001) Gene expression:  The odd coupling.  Nature. Oct.11 Vol.413, 583-585.

Brower-Toland BD, Smith CL, Yeh RC, Lis JT, Peterson CL, and Wang MD (2001) Mechanical disruption of individual nucleosomes reveals a reversible multistage release of DNA. Proc. Natl. Acad. Sci. USA, In press.

Grishok, A., Shin, T-H. Tabara, H., and Mello, C.C. (2000)  Genetic requirements for the inheritance of RNAi in C. elegans.  Science, 287, 2494-2497.

Zhu Z, Delprato A, Merithew E, Lambright DG.  Determinants of the broad recognition of exocytic Rab GTPases by Mss4.  Biochemistry 40: 15699-15706.

Jaskelioff M, Gavin IM, Peterson CL, and Logie C. (2000)  SWI/SNF-mediated nucleosome remodeling: Role of histone octamer mobility in the persistence of the remodeled state. Mol. Cell Biol. 20: 3058-3068

Lietzke SE, Bose S, Cronin T, Klarlund J, Chawla A, Czech MP, Lambright DG (2000).  Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains. Mol Cell.  Aug;6(2): 385-94.

Seung, E, Iwakoshi, N, Woda, BA, Markees, TG, Mordes, JP, Rossini, AA, and Greiner, DL (2000): Allogeneic hematopoietic chimerism in mice treated with sub-lethal myleoblation and anti-CD154 antibody:absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD-Lt mice. Blood, 95:2175-2182.

Lawe, D. C., Chawla, A., Merithew, E., Dumas, J. J., Carrington, W., Forgarty, K., Lifshitz, L., Tuft, R., Lambright, D. G. & Corvera, S. (2002) "Sequential roles for EEA1 and Rab5 in tethering and fusion of early endosomes", J. Biol. Chem. 277: 8611-8617.