Jie Song2

Jie Song, PhD

Associate Professor

Faculty Appointment in:

      Research Interests              Biography              Recent Publications          Rotations            Grants             

Research Interests


Synthetic tissue grafts and smart implants guiding the repair and regeneration of musculoskeletal tissues

With an aging population, the demand for synthetic tissue scaffolds assisting the repair and reconstruction of musculoskeletal tissue defects resulting from trauma, aging, cancer and metabolic diseases is \rising. Our lab is interested in 1) developing new biomaterial- and stem cell-based approaches towards bone and cartilage tissue regeneration, particularly dealing with hard-to-heal tissue defects resulting from aging, diabetes, and traumatic injuries; 2) identifying novel factors regulating stem cell renewal and skeletal tissue regeneration; 3) identifying new targets for the development of disease modifying drugs of osteoarthritis; and 4) improving the osteointegration of and reducing periprosthetic infections associated with existing orthopedic metallic implants. Many of the synthetic scaffolds we designed are programmed with unique physical properties to facilitate facile surgical delivery (injectable formulations; minimally invasive in vivo deployment), tunable & predictive in vivo degradation profiles, and spatially controlled presentation and temporally controlled release of bioactive factors for regulating stem/progenitor cell fate within the tissue niche environment.

jie research


B.S. 1995, Fudan University, P.R. China
Ph.D. 1999, Michigan State University
Postdoctoral Fellow 1999-2002, University of California Berkeley & Lawrence Berkeley National Laboratory
Staff Scientist 2002-2006, Lawrence Berkeley National Laboratory

Recent Publications

For a list of Dr Song publications, follow this link: http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40595708/?sort=date&direction=descending 


Potential Rotation Projects

1. Design and evaluation of smart synthetic bone / cartilage tissue grafts

2. Metallic implant surface modifications for reducing periprosthetic infections

3. New therapeutic targets for the development of disease modifying drugs of osteoarthritis














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Federal government and non-for-profit organization:
Implant surface modification strategies against periprosthetic infections
PI: Jie Song, 2015-2020
Sponsor: NIH/NIAMS (R01)

“Osteogenic synthetic bone grafts for the repair of musculoskeletal defects”
PI: Jie Song, 2008-2013
Sponsor: NIH/NIAMS (R01AR055615)
“A nanostructured approach to complex tissue scaffolds and smart implants”
PI: Jie Song, 2009-2013
Sponsor: NIH/NIGMS (R01GM088678)
“Chondrogenic composite grafts for the repair of cartilage defects”
PI: Jie Song, 2009-2011
Sponsor: NIH/NIAMS (R21AR056866)

"Synthetic periosteal tissue microenvironment enhancing the repair of critical-sized long bone defects”
PI: Jie Song, 2010-2013
Sponsor: DOD/CDMRP (OR090043)
“VivaCT 75 High Speed in vivo MicroCT Scanner”
PI: Jie Song, 2010-2011
Sponsor: NIH/NCRR (1S10RR027082)

Other sponsors:

Musculoskeletal Transplant Foundation
American Society for Bone and Mineral Research
Massachusetts Technology Transfer Center
Worcester Foundation for Biomedical Research
President’s Office, University of Massachusetts
CVIP, University of Massachusetts
Clinical and Translational Science Pilot Project Program, UMMS
Life Science Moment Fund, UMMS

Lab Members



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