2013 CTSA

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Lawrence’s Down syndrome research gets boost from Hood Foundation

Lawrence’s Down syndrome research gets boost from Hood Foundation

Jeanne B. Lawrence, PhD, has been awarded a $500,000 grant from the Charles H. Hood Foundation to investigate the use of chromosomal therapy as a means of inactivating the extra copy of chromosome 21 responsible for disease pathologies in mouse models of Down syndrome.

FDA grants orphan drug status for Hepatitis C treatment developed by MassBiologics

FDA grants orphan drug status for Hepatitis C treatment developed by MassBiologics

UMass Medical School’s MassBiologics has received an orphan drug designation from the U.S. Food and Drug Administration for MBL-HCV1, a monoclonal antibody developed to prevent the recurrence of hepatitis C virus in patients receiving a liver transplant.

UMMS technology licensed to develop cancer immunotherapies

UMMS technology licensed to develop cancer immunotherapies

“Anti-gal” technology developed at UMMS has been licensed to newly formed biopharmaceutical company Agalimmune Ltd. for the purpose of developing innovative immunotherapies for the treatment of solid tumor cancers.

Research shows antifungal medicine may increase vulnerability to flu

Scientists at the UMMS and the Wellcome Trust Sanger Institute have discovered evidence that a widely used antifungal medicine increases susceptibility to flu infection in mice and cell cultures.

Examining how cytomegalovirus spreads from mother to fetus

Using next generation sequencing and population genetic modeling, scientists at UMass Medical School and the Ecole Polytechnique Fédérale de Lausanne have found that cytomegalovirus evolves rapidly and dramatically in humans. These findings, published in PLoS Genetics, provide new genetic targets that could impede the evolution of CMV and prevent its spread.

Jeanne Lawrence hints at new Down syndrome research in Globe story

Jeanne B. Lawrence, PhD, who earlier this year showed that it was possible to shut down the extra copy of chromosome 21, told the Boston Globe that the discovery is already providing new insights about what exactly goes wrong within Down syndrome cells.

Child born with HIV still in remission after 18 months off treatment, experts report

A 3-year-old Mississippi child born with HIV and treated with a combination of antiviral drugs very early remains free of active infection 18 months after all treatment ceased, according to an updated case report in The New England Journal of Medicine. Katherine Luzuriaga, MD, is senior author on the report.

Luzuriaga named vice provost for clinical and translational research

Katherine Luzuriaga, MD, professor of molecular medicine, pediatrics and medicine, has been named vice provost for clinical and translational research.

Two genetic wrongs make a biochemical right

A recent discovery by UMass Medical School scientists may provide researchers with a new approach for studying and potentially treating Fragile X syndrome.

UMMS study: Activating aging in tumor cells may be effective against lymphoma

UMMS scientists have shown that diffuse large B-cell lymphoma (DLBCL) may be susceptible to treatment by re-activating the normal aging program in tumor cells so they can no longer divide.

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