Leadership in Translational Medicine and Science

The Department of Medicine is proud of its affiliation with the following Centers of Excellence:

Cancer Center of Excellence

The Cancer Center of Excellence focus is translational oncology research. The underlying principle of the center is to combine an understanding of the biology of cancer with innovative and effective measures for the prevention, diagnosis and treatment of the disease. 
Dr. Blute specializes in urinary tract reconstruction in bladder cancer patients; the localization and clinical significance of tumor suppression genes in prostate cancer; and pioneering surgical techniques in advanced renal cancer.

  • Alan Rosmarin, MD professor of medicine and division chief of Hematology/Oncology, has an established research program focused on hematologic malignancies with a special interest in acute leukemia.

Cardiovascular Center of Excellence

The Cardiovascular Center of Excellence is directed by Dr. John Keaney, Chief of Cardiovascular Medicine and Dr. Louis Messina, Chief of Vascular Surgery. Drs. Keaney and Messina have identified several themes of interest to the Cardiovascular Center that are in alignment with UMass expertise and priorities.

  • Robert Goldberg, MD leads a team of investigators in community-based studies of natural history and primary and secondary prevention of coronary heart disease, heart failure, and deep venous thrombosis.
  • Ira Ockene, MD leads a program focused on the prevention and management of Type 2 diabetes in underserved populations.
  • Marcus Cooper, MD is a young clinical investigator investigating therapies that promote brown versus white fat development.

Diabetes Center for Excellence

David M. Harlan, MD, Co-Directs the UMass Medical School/UMass Memorial Health Care Diabetes Center of Excellence and is the Department of Medicine’s Diabetes Division Chief.  Since joining UMass in 2009, Dr. Harlan has focused on three significant goals: (1) to build a patient-centered clinical care system that provides the most up-to-date therapies, (2) to train the next generation diabetes clinician and researcher, and (3) to conduct the basic and clinical research required to better understand why people develop diabetes, and to bring promising research advances safely into clinical trials.

Dale L. Greiner, PhD, Co-Directs the UMass Medical School/UMass Memorial Health Care Diabetes Center of Excellence and is a Professor in the Department of Molecular Medicine.  Dr. Greiner has focused on type 1 diabetes research since 1983. His research program has 3 goals: (1) to conduct basic research to understand why people develop diabetes, (2) to use humanized mice, i.e., immunodeficient mice engrafted with functional human cells, tissues, and immune systems, as a preclinical bridge to test new approaches for prevention and treatment of T1D without putting patients at risk, and (3) to safely bring these basic and translational research discoveries into clinical trials. 

Muskuloskeletal Center for Excellence

Research in the Musculoskeletal Center of Excellence is directed by David Ayers MD, Chair, Department of Orthopedics and Ellen M. Gravallese MD, Chief, Division of Rheumatology, Department of Medicine. Drs. Ayers and Gravallese have identified several research areas important to the Center of Excellence.

Dr. Ellen Gravallese’s research interests have focused on the pathogenesis of inflammatory arthritis and the effects of inflammation on bone. As Director of Translational Research for the Center, Dr. Gravallese has organized a collaborative program studying the role of microRNAs in the pathogenesis of rheumatoid arthritis (led by Drs. Gravallese and Yukiko Maeda, Rheumatology) and osteoarthritis (led by Drs. Patricia Franklin and Paul Fanning, Orhtopedics). Three interactive and collaborative grants study microRNAs as factors regulating disease processes and as potential biomarkers in arthritis.

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